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Journal of the Korean Academy of Rehabilitation Medicine 2000;24(2):318-325.
Relationship among Estradiol, Lipid Profile, Biochemical Markers, and Bone Mineral Density according to Postmenopausal Period.
Kim, Ghi Chan , Jeong, Ho Joong , Jeong, Sang Wook , Chung, Heung Chae
Department of Rehabilitation Medicine, Kosin University College of Medicine.
폐경기간에 따른 혈중 Estradiol과 Lipid Profile, 골대사 표지자 및 골밀도와의 연관 관계
김기찬, 정호중, 정상욱, 정흥채
고신대학교 의학부 재활의학과
Abstract

Objective
To determine whether estradiol (E2), lipid profile, biochemical markers, and bone mineral density (BMD) are related according to postmenopausal period.


Method
One hundred fifty four women were divided into four groups according to the time past menopause: group I (0∼5 years), group II (6∼10 years), group III (11∼15 years), group IV (more than 16 years). Group I, II, III were subdivided into osteoporosis group (t-score<⁣2.5) and non-osteoporosis group (t-score≥⁣2.5). E2, lipid profile, osteocalcin, alkaline phosphatase, deoxypyridinoline, and BMD by DEXA were measured in all groups.


Results
There were significant inverse correlation between BMD and postmenopausal period (p<0.05). Deoxypyridinoline and osteocalcin were correlated with postmenopausal period but there was no statistical significance. Deoxypyridinoline and osteocalcin were increased in osteoporosis group compared to non-osteoporosis group but there was no statistical significance. E2 had significant inverse correlations with postmenopausal period (p<0.05). E2 had no correlation with factors such as biochemical markers and lipid profile in group I, II, III but had adverse correlation with deoxypyridinoline in group IV.


Conclusion
No specific biochemical markers regarding the duration of menopause were found. Regardless of the duration of menopause, checking both osteocalcin and deoxypyridinoline was statistically significant for the evaluation of postmenopausal osteoporosis.

Key Words: Postmenopausal osteoporosis, Estradiol, Osteocalcin, Deoxypyridinoline, Bone mineral density
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