J Korean Acad Rehabil Med Search


Journal of the Korean Academy of Rehabilitation Medicine 2000;24(6):1041-1045.
Effects of Steroid on the Development of Neuropathic Pain with an Experimental Model of Peripheral Neuropathy.
Lee, Sang Heon
Department of Rehabilitation Medicine, Korea University College of Medicine.
스테로이드가 흰쥐의 신경병변성 동통 발생에 미치는 효과
고려대학교 의과대학 재활의학교실

The purpose of this study was to evaluate the anti-inflammatory effect of steroid in the neuroma plays a key role in the development of neuropathic pain.

Materials consisted of 21 male Sprague-Dawley rats (8 weeks old, 180∼200 g), which were divided into a steroid (n=9) and control group (n=12). Neuropathic pain was produced by unilateral transection of the superior caudal trunks at the level between the S3 and S4 spinal nerves. We compared two groups of rats, the steroid group injecting 1 ml (40 mg) of Methylprednisolone (Depo-Medrol), and the control group injecting 1 ml of nomal saline on operation site just after operation.

Behavioral reactions to mechanical allodynia were checked using a von Frey hairs of 2.0 g (19.6 mN) bending force at pre-operation, post-operative 1, 4, 7, 10 & 14 day to evaluate the steroid effect on the development of neuropathic pain.

The steroid group exhibited less tail-flick frequencies to mechanical stimulation: 14.8⁑17.0%, 28.1⁑18.3%, 38.1⁑28.3% at post-operative 4, 7, 10 days respectively in control group; 30.3⁑21.2% 43.6⁑21.3%, 47.2⁑20.8% at post-operative 4, 7, 10 days, respectively. But there was no significant difference between both groups at post-operative 14 days. The steriod reduced the pain at early stage of neuropathic pain development, but failed to decrease the pain level in late stage.

These results suggest that the steroid induced anti-inflammatory effect in the injured neuroma is not a key factor in the development of neuropathic pain.

Key Words: Neuropathic pain, Steroid, Allodynia


Browse all articles >

Terms of Use   |   Privacy Polity
Editorial Office
Department of Rehabilitation Medicine, Seoul National University Hospital
101 Daehak-ro, Jongno-gu, Seoul, Korea
Tel: +82-10-8678-2671    Fax: +82-2-6072-5244    E-mail: edit@e-arm.org; edit.karm@gmail.com
Business Registration: 110-82-07460                

Copyright © 2024 by Korean Academy of Rehabilitation Medicine.

Developed in M2PI

Close layer