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Journal of the Korean Academy of Rehabilitation Medicine 2001;25(2):308-314.
Differential Skeletal Response to Ovariectomy in Young and Old Rats.
Heo, Jai Kyun , Han, Seung Hoon , Kim, Mi Jung , Choi, Ki Seob , Park, Si Bog , Lee, Sang Gun , Paik, Doo Jin , Lee, Kang Choon
1Department of Rehabilitation Medicine, College of Medicine, Hanyang University.
2Department of Anatomy, College of Medicine, Hanyang University.
3Drug Targeting Lab., College of Pharmacy, Sungkyunkwan University.
젊은 쥐와 늙은 쥐의 난소 절제에 대한 골격계 반응의 차이
허재균, 한승훈, 김미정, 최기섭, 박시복, 이상건, 백두진1, 이강춘2
한양대학교 의과대학 재활의학교실, 1해부학교실, 2성균관대학교 약학대학 약물표적화실
Abstract

Objective
The purpose of this study is to evaluate the loss of bone mineral density on ovariectomized (ovx) rat in young and old rats.


Method
Total 110 Sprague-Dawley female rats which composed of 3 months aged 88 rats and 12 months aged 22 rats were used. They were divided randomly into 5 ovx groups (15 rats for each group) and 5 sham operation group (7 rats for each group). The bone mineral density was measured by Hologic 4,500 Fan Beam bone densitometry at the time of second postoperation week, 4th week, 8th week, and 16th week in young aged group and 4th, 8th week in old aged group.


Results
The bone mineral density in young ovx rats was decreased measured at 2 week, 4 week and 8 week, but not 16 week compared with that of sham operation rats (p<0.05). In old rats, there was no significant change in bone mineral density between ovx and sham group (p>0.05).


Conclusion
For the purpose of osteoporosis inducing experiment, young aged rat is more reliable for the detection of bone density change than old aged rat and the bone mineral density change will be continued at least 16 week postovariectomy period.

Key Words: Osteoporosis, Bone mineral density, Ovariectomized rat
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