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Journal of the Korean Academy of Rehabilitation Medicine 2001;25(4):643-652.
Neuropathic Pain Model Induced by Electrical Injury of Sciatic Nerve in Rats.
Lee, Yang Soo , Lee, Ki Hoon , Kim, Young Eun , Jung, Tae Du , Kim, Poong Taek
Department of Rehabilitation Medicine, Kyungpook National University College of Medicne.
흰쥐 좌골신경에 전기적 손상을 준 신경병변성 동통 모델의 개발
이양수, 이기훈, 김영은, 정태두, 김풍택
경북대학교 의과대학 재활의학교실

The purpose of this study was to develop a new neuropathic pain model in rat.

Twenty Sprague-Dawley adult male rats, 10 for control and 10 for experimental, were anesthetized and their sciatic nerves were exposed. In an experimental group, exposed nerve was injured with 10 volts electrical current for 10 seconds. The mechanical and thermal allodynia and pain behavior were evaluated in pre-electrical injury and post-injury 1, 2, 3 days, 1, 2, 3, 4, 6 and 8 weeks. The mechanical allodynia was evaluated by the frequency of response to 5 stimulations of von Frey hairs (4.31 and 4.56) and the thermal allodynia was tested by withdrawal latency to stimulation with radiant heat. Spontaneous pain behavior (paw shaking, paw elevation) was observed for 5 minutes in the cage.

The experimental group exhibited significantly higher withdrawal frequency to mechanical stimulation: from post-injury 3 days to 6 weeks for von Frey hair 4.31 and from 2 days to 4 weeks for von Frey hair 4.56 (p<0.05). There was no difference between two groups in withdrawal latency to radiant heat stimulation. The experimental group showed spontaneous pain behavior but control group did not. In electron microscopic finding, prominent myelin destruction and axonal sprouting were observed in experimental group.

These results suggest that a new neuropathic pain model can be made by 10 volts electrical injury for 10 seconds to rat sciatic nerve.

Key Words: Electrical injury, Neuropathic pain model, Sciatic nerve, Rat


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