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Journal of the Korean Academy of Rehabilitation Medicine 2003;27(1):80-84.
Relations of Glycosylated Hemoglobin and Parameters of Nerve Conduction Study in Diabetic Peripheral Polyneuropathy.
Jeong, Tae Seok , Choi, Ki Sub , Kim, Hyun Jung , Park, Young Seok
1Department of Rehabilitation Medicine, Eulji University School of Medicine, Korea.
2Department of Rehabilitation Medicine, Hanyang University College of Medicine, Korea.
당뇨병성 신경병증 환자에서 당화 혈색소와 신경전도 검사 척도와의 관계
정태석, 최기섭1, 김현정, 박영석
을지대학교 의과대학 재활의학교실, 1한양대학교 의과대학 재활의학교실
Abstract
Objective
This study was performed to determine the relations of glycosylated hemoglobin (HbA1c) and parameters of nerve conduction study (NCS) in diabetic peripheral polyneuropathy patients.


Method
Prospectively, total 40 patients with non-insulin dependent diabetes mellitus were included in the study. NCS was performed on median, ulnar, posterior tibial, deep peroneal, superficial peroneal, and sural nerves. Distal latency and conduction velocity (CV) of compound muscle action potential (CMAP), distal latency and amplitude of sensory nerve action potential (SNAP) were used as parameters of NCS. Multiple linear regression analysis were used to analyze the relations of HbA1c and parameters of NCS, after adjustment for age, height, weight, and disease duration of diabetes mellitus.


Results
HbA1c level had an inverse relation to CV of median motor nerve (β=⁣1.272, p<0.01), ulnar motor nerve (β=⁣1.287, p<0.01), posterior tibial nerve (β=⁣0.982, p<0.05), and deep peroneal nerve (β=⁣1.449, p<0.05).


Conclusion
This study indicates that HbA1c level was inversely related to motor nerve CV, and that sustained hyperglycemia may be involved in demyelination of motor nerves. Analysis of motor nerve CV related to HbA1c is expected to be useful in the follow-up or efficacy study of diabetes mellitus neuropathy as baseline data. (J Korean Acad Rehab Med 2003; 27: 80-84)

Key Words: Non-insulin dependent diabetes mellitus, Peripheral polyneuropathy, Glycosylated hemoglobin (HbA1c), Nerve conduction study


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