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Journal of the Korean Academy of Rehabilitation Medicine 2003;27(1):90-95.
The Preventive Effect of Nimodipine on the Cisplatin Induced Neuropathy.
Kim, Chang Hwan , Choi, Hyun Chul , Roh, Gill Ho
Department of Rehabilitation Medicine, Inha University College of Medicine, Korea.
Nimodipine에 의한 Cisplatin 신경병증의 예방 효과
김창환, 최현철, 노길호
인하대학교 의과대학 재활의학과
Abstract
Objective
Cisplatin has effectiveness in the treatment of solid tumor by active cytotoxic action, but with significant side effects such as peripheral neuropathy. To investigate the prevention of neuropathy, nimodipine was examined.


Method
Fifty female rats (Sprague-Dawley strain; BW 210∼260 g, 12∼15 week old) were used: control group; cisplatin group; cisplatin-nimodipine 2 week group, 10; ciplatin-nimodipine 4 week group; base group. Peripheral neuropathy was induced by intraperitoneal injection of the cisplatin (0.04 mg/ml, 1 ml/kg/ip/ for 2 weeks). Nimodipine was injected intraperitoneally for 2 weeks and 4 weeks in cisplatin-nimodipine 2 week group and cisplatin-nimodipine 4 week group, respectively. Motor and sensory nerve conduction studies were done using in rat tail nerve from the beginning and biweekly till to 10th week.


Results
Weight reduction was significant in cisplatin group at 2nd week (p<0.05). The latencies of motor and sensory nerves were delayed in 2nd, 4th week in all groups with cisplatin (p<0.05) and the recovered after 6th week in all groups. The amplitudes of motor and sensory nerves in these groups haven't made any difference compared with control group (p>0.05).


Conclusion
The neurotoxicity of cisplatin revealed in motor and sensory neurons. The neuropathy has recovered to control value in 6th week and the preventive effect of nimodipine was transient. (J Korean Acad Rehab Med 2003; 27: 90-95)

Key Words: Cisplatin, Neuropathy, Nimodipine


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