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Journal of the Korean Academy of Rehabilitation Medicine 2003;27(1):121-125.
Effects of Bone Density as Injections of Salmon Calcitonin Micropheres in Ovariectomized Rats.
Han, Seung Hoon , Choi, Jeong Won , Choi, Ki Soeb , Park, Si Bog , Lee, Sang Gun , Paik, Doo Jin , Kim, Mi Jung
1Department of Rehabilitation Medicine, Hanyang University College of Medicine, Korea.
2Department of Anatomy, Hanyang University College of Medicine, Korea.
난소 절제 쥐에서 칼시토닌 미립자의 골밀도에 대한 효과
한승훈, 최정원, 최기섭, 박시복, 이상건, 백두진1, 김미정
한양대학교 의과대학 재활의학교실, 1해부학교실
Abstract
Objective
This study was evaluated the bone protective effects of the salmon calcitonin microspheres against the cancellous bone loss in the ovariectomized rats.


Method
The experimented rats were total 50 Sprague- Dawley female rats. They were divided randomly 5 groups. The treatment was initiated on the first day after surgery and continued for a period of 4 weeks. Bone measurements were performed in the distal femoral metaphysis and 5th lumbar vertebrae with dual energy x-ray absorptiometry at the time of 2nd week and 4th week after drug injection in all groups.


Results
The cancellous bone density in the ovariectomized rats treated with high dose of the salmon calcitonin microspheres was significantly higher than that of the free salmon calcitonin-treated ovariectomized rats, but less than that of the sham-operated control rats.


Conclusion
This study shows that the salmon calcitonin microspheres were evaluated for protection against the cancellous bone loss in the ovariectomized rats. The bone protective effect of the salmon calcitonin microspheres was greater than that of the free salmon calcitonin. (J Korean Acad Rehab Med 2003; 27: 121-125)

Key Words: Calcitonin, Microspheres, Bone density, Ovariectomy, Rats
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