| The Effect of Demeclocycline on the Management of Syndrome of Inappropriate Secretion of Antidiuretic Hormone in Brain Injured Patient. |
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Jeon, Hyangbae , Kim, Hyundong |
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Department of Rehabilitation Medicine, Inje University College of Medicine, Korea. jhbrm@medigate.net |
| 회복기 뇌손상 환자에서 항이뇨 호르몬 이상 분비 증후군의 치료 경험 1례의식저하와 관련된 저나트륨혈증에서 Demeclocycline의 효과 증례 보고 |
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전향배, 김현동 |
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인제대학교 의과대학 재활의학교실 |
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| Abstract |
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The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a frequent complication of severe head trauma. Fluid restriction is treatment choice of SIADH in patients with traumatic brain injury (TBI), but fluid restriction is limited because they need sufficient calories. We described a patient who, on the four months after a head injury, presented with deterioration of consciousness, which coincided with the development of the SIADH, and which rapidly reversed with the correction of the hyponatremia by demeclocycline with minimal fluid restriction. We suggest that SIADH should be included in the differential diagnosis of deterioration of consciousness during the recovery period of the patients suffering from head injury because unexpected clinical deterioration may often have a reversible cause. Also, demeclocycline will be useful, which allows for increased fluid liberalization and for provision of adequate calories, in the treatment of the SIADH in patients with TBI. (J Korean Acad Rehab Med 2003; 27: 438-441) |
| Key Words:
Syndrome of inappropriate secretion of antidiuretic hormone, Traumatic brain injury, Fluid restriction, Demeclocycline |
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