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Journal of the Korean Academy of Rehabilitation Medicine 2005;29(2):193-200.
Graded Spinal Cord Contusive Rat Model by a Weight-drop Device.
Lee, So Young , Kim, Ji Hoon , Cheon, Seung Wook , Kim, Jae Hyung , Choi, In Sung , Kang, Kyong Ju , Lee, Sam Gyu , Lee, Min Chyul , Kim, Hyung Beom , Park, Seung Jin
1Department of Physical Medicine & Rehabilitation, Chonnam National University Medical School, Korea. sam91@jnu.ac.kr
2Department of Physical Medicine & Rehabilitation, Chonnam National University Hwasun Hospital, Korea.
3Department of Pathology, Chonnam National University Medical School, Korea.
4Department of Biomedical Engineering, Chonnam National University Hospital, Korea.
척수좌상 유발장치에 의한 손상단계별 척수좌상 백서모델
이소영1, 김지훈, 천승욱, 김재형1, 최인성, 강경주, 이삼규, 이민철2, 김형범3, 박승진3
전남대학교 의과대학 재활의학교실, 1화순전남대학교병원 재활의학과, 2전남대학교 의과대학 병리학교실, 3전남대학교병원 의공학과
To investigate the reproducibility of graded spinal cord contusion by a weight-drop device, and to establish a graded spinal cord contusive rat model based on the functional analysis and morphometric measurement.
The weight-drop device developed was composed of impactor with a guidance rod, stereotaxic frame and spine stabilizing device. We investigated the reproducibility of impact by reliability analysis two weeks later. Thirty Sprague-Dawley rats were injured by the weight-drop device from the height of 12.5, 25.0 and 50.0 mm. The three groups of each drop-height (n=10) as well as laminectomized sham group (n=10) were subjected to functional analysis by Basso Beattie Bresnahan Locomotor Scales (BBB scales) and inclined plane test after contusion forfour weeks. The morphometric measurement was performed at regularly spaced intervals including the epicenter according to the graded drop-height.
The impact of weight-drop was significantly increased according to the drop-height (p<0.05) and revealed high reproducibility. The changes of BBB scales and maximal angle of inclination had an inverse correlation with the contusion severity (p<0.05). There was an inverse correlation between the amount of residual white matter and drop-height (p<0.05).
The weight-drop device newly developed provides a constant and reproducible spinal cord contusion model. (J Korean Acad Rehab Med 2005; 29: 193-200)
Key Words: Spinal cord contusion, Weight-drop device, Morphometric measurement, Epicenter, Rat model
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