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Journal of the Korean Academy of Rehabilitation Medicine 2005;29(4):406-412.
The Response of the Injured Articular Cartilage of Rabbit Knee after Injection of Autologous Blood.
Kim, Soo A , Kim, Eui Han , Kim, Jin Il , Jang, Il , Lee, Ji Soo , Lee, Yang Kyun
1Department of Rehabilitation Medicine and 1Pathology, Soonchunhyang University College of Medicine. sooapmr@hanmail.net
2Bone's Orthopedics.
3Jang's Hospital.
4Gaya Medical Hospital.
토끼의 실험적 슬관절 연골 손상에서 자가 혈액 주입의 효과
김수아, 김의한1, 김진일2, 장일3, 이지수4, 이양균
순천향대학교 의과대학 재활의학교실, 1병리학교실, 2본정형외과의원, 3장재활의학과의원, 4가야메디컬의원
Abstract
Objective
To evaluate the effects of proliferant by injecting blood into the articular cartilage defect.
Method
The patella of rabbits were dislocated laterally and 2 mm circular and 2 mm depth full-thickness defect was made in the articular cartilage. We injected 0.2 cc autologous blood to the right defect and normal saline to the left one at 1 week after operation for six times with a 1 week interval. After injection for six weeks, the articular cartilage defect were obtained and stained with H-E and S-100.
Results
The surface of the saline-injected group was easily distinguishable from the surrounding articular cartilage. But the blood-injected group had similar appearance to the surrounding cartilage, with the margin of the defect barely discerptible. Strong S-100 stained immune cartilage cells were observed in the blood-injected group.
Conclusion
The repairing process of the injured articular cartilage using autologous blood was shown to be much better than that of saline-injected group although the observation period was short and the number of animal was small. So we found that autologous blood effectively repaired osteochondral defects. (J Korean Acad Rehab Med 2005; 29: 406-412)
Key Words: Articular cartilage, Proliferant, Dextrose, Blood
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