The Efficacy of Donepezil on Cognitive Dysfunction in Subacute Post-stroke Patients.

, Kim, Deog Young; , Park, Chang il; , Ohn, Suk Hoon; , Yang, Eun Joo; , Ahn, So Young; , Na, Sang Il

Original Article

Journal of the Korean Academy of Rehabilitation Medicine 2006;30(2):111-115.

Kim, Deog Young , Park, Chang il , Ohn, Suk Hoon , Yang, Eun Joo , Ahn, So Young , Na, Sang Il

Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Korea. graceloves@medimail.co.kr

아급성기 뇌졸중 환자의 인지 기능 저하에서 Donepezil의 효과

김덕용, 박창일, 온석훈, 양은주, 안소영, 나상일

연세대학교 의과대학 재활의학교실 및 재활의학연구소

Abstract

Objective
To evaluate the efficacy of donepezil on cognitive dysfunction in subacute post-stroke patients.
Method
Sixty subacute stroke subjects were enrolled and randomly assigned into an experimental or control group. There was no significant difference between the two groups in age, sex and post-onset duration. Donepezil 5 mg was administered daily for 6 weeks to patients in the experimental group. Mini-Mental Status Examination (MMSE), Wechsler Memory Test (WMT) and Colored Progressive Matrices (CPM) were performed before and 6 weeks after administration of the study drug in both groups.
Results
There was no difference between the two groupsin the MMSE, WMT, CPM scores at baseline. Six weeks later, the total score, memory input, recall and judgement as measured by the MMSE and the score on the WMT were significantly more improved in the experimental group when compared to the control group (p＜0.05). However, there was no significant difference between the two groups on the CPM score.
Conclusion
These results suggested that donepezil may be helpful for improving cognitive function, especially memory in post-stroke patients. (J Korean Acad Rehab Med 2006; 30: 111-115)

Key Words: Donepezil, Cognitive function, Memory, Stroke