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Journal of the Korean Academy of Rehabilitation Medicine 2006;30(4):406-408.
Leigh Syndrome : Two cases report.
Lee, Zee Ihn , Park, Hea Woon , Kim, Chul Hyun , Lee, Yong Bum
1Department of Rehabilitation Medicine, Catholic University of Daegu College of Medicine, Korea.
2Department of Rehabilitation Medicine, Kyungpook National University College of Medicine, Korea. leeyb103@hotmail.com
Leigh 증후군 ⁣증례 보고⁣
이지인, 박해운, 김철현1, 이용범1
대구가톨릭대학교 의과대학 재활의학교실, 1경북대학교 의과대학 재활의학교실
Leigh syndrome is a subacute necrotizing encephalomyelopathy of infancy or early childhood. The clinical presentation can be highly variable. The classical presentations are central hypotonia, developmental regression or arrest, ataxia, ophthalmoplegia, and abnormal respiratory pattern. Diagnosis is usually confirmed by radiologic evidence of focal, bilateral and usually symmetric lesions of the both gray and white matter in the brain and the spinal cord. We experienced 2 cases of Leigh syndrome in a brother and sister.The first case, 4 year-old boy, was misdiagnosed as a cerebral palsy initially, but after acute infection, he revealed developmental regression and abnormal movement. His disease was confirmed by typical magnetic resonance imaging findings. The second case, 1 year-old girl with nystagmus, showed bilateral symmetric high signal intensity in globus pallidus on T2WI. We reported these cases with a brief review of the related literature. (J Korean Acad Rehab Med 2006; 30: 406-408)
Key Words: Leigh syndrome


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