The Effect of Etidronate Disodium on Rat's Bone and Soft Tissue.

, Han, Soo Jeong; , Yoon, Tae Sik; , Lee, Shi Nae; , Heo, Yun; , Kim, Jung Yeun; , Lee, Kyung Whan

Original Article

Journal of the Korean Academy of Rehabilitation Medicine 2006;30(5):496-501.

Han, Soo Jeong , Yoon, Tae Sik , Lee, Shi Nae , Heo, Yun , Kim, Jung Yeun , Lee, Kyung Whan

¹Department of Rehabilitation Medicine, Ewha Womans University College of Medicine, Korea. 5smartbeli@medimail.co.kr
²Department of Pathology, Ewha Womans University College of Medicine, Korea.

에티드로네이트가 흰쥐의 골 및 연부 조직에 미치는 영향

한수정, 윤태식, 이시내¹, 허윤, 김정연, 이경환

이화여자대학교 의과대학 재활의학교실, ¹병리학교실

Abstract

Objective
To evaluate the effects of etidronate disodium on bone and soft tissue, especially on bone mineral density, and mucosal changes of the aorta and esophagus.
Method
Male Sprague-Dawley rats were randomly divided into 2 separate groups: one with etidronate disodium and one without etidronate disodium. Bone mineral density (BMD) in lumbar vertebrae, femur, and a simple X-ray of the whole body were obtained. The abdominal aorta and esophagus were assessed histopathologically in post treatment.
Results
In post treatment for 12 weeks, the extent of decrease in BMD of the group with etidronate disodium was less than that of the group without etidronate disodium (p＜0.05). There was no evidence of aorta and heart valve calcification in the simple X-ray, nor was there intima-media thickening, atheroma formation and calcification in aorta and esophageal irritation findings in pathologic examinations in both groups.
Conclusion
The results suggested that etidronate disodium had an inhibitory effect on bone mineral loss and had the esophageal tolerability and safety, but no difference in aorta calcification and antiarthrogenic effects, including aorta wall thickness in this study. (J Korean Acad Rehab Med 2006; 30: 496-501)

Key Words: Etidronate disodium, Bone mineral density, Aorta, Esophagus