Coagulation Status of the Post-acute Spinal Cord Injured Patients.

, Shin, Jeong Bum; , Ko, Hyun Yoon; , Sohn, Hyun Joo; , Lee, Kyung Mi; , Han, Ji Eui; , Shin, Yong Beom; , Chang, Jae Hyeok; , Park, Ji Sang

Original Article

Journal of the Korean Academy of Rehabilitation Medicine 2006;30(6):560-564.

Shin, Jeong Bum , Ko, Hyun Yoon , Sohn, Hyun Joo , Lee, Kyung Mi , Han, Ji Eui , Shin, Yong Beom , Chang, Jae Hyeok , Park, Ji Sang

¹Department of Rehabilitation Medicine, Pusan National University College of Medicine, Korea. yi0314@medimail.co.kr
²Dong-Eui Hospital, Korea.

급성기 이후 척수손상 환자의 혈액응고 상태

신정범¹, 고현윤, 손현주, 이경미, 한지의, 신용범, 장재혁, 박지상

부산대학교 의과대학 재활의학교실, ¹동의의료원 재활의학과

Abstract

Objective
Deep vein thrombosis (DVT) is one of the most common complications of acute spinal cord injury (SCI). It is well known that the incidence of DVT in post-acute SCI patients decreases to a level similar to that in the general population. The aim of this study was to evaluate the blood coagulation status and the possibility of DVT occurrence in post-acute SCI patients.
Method
Twenty-three SCI patients (SCI group) were included in this study. Ten patients having spinal fracture with no evidence of SCI were used as the control group. Coagulation status was examined using factor VIII antigen, factor VIII procoagulant, fibrinogen, D-dimer, protein C, and protein S in both groups. Duplex ultrasonography was performed for the diagnosis of DVT.
Results
Prevalence of the abnormally decreased protein S level was significantly high in the SCI group (87%) than in the control group (30%). Prevalence of the abnormally increased F VIII:Ag, F VIII:C, and fibrinogen levels in the SCI group were significantly high in the SCI group (p＜0.05).
Conclusion
We conclude that post-acute SCI patients may have hypercoagulability. Proper physical prevention and thromboprophylaxis should be considered in post-acute SCI patients because they have relatively higher risk of thromboembolic complication. (J Korean Acad Rehab Med 2006; 30: 560-564)

Key Words: Deep vein thrombosis, Spinal cord injury, Coagulation status, Hypercoagulability