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Journal of the Korean Academy of Rehabilitation Medicine 2006;30(6):632-638.
Clinical Implication of Sniff Nasal Inspiratory Pressure in Patients with Duchenne Muscular Dystrophy.
Chang, Hyun Jung , Kang, Seong Woong , Park, Yoon Ghil , Kim, Wan , Yoo, Tae Won , Lee, Byung In
1Department Physical Medicine and Rehabilitation, Samsung Medical Center & Center for Clinical Medicine, Sungkyunkwan University School of Medicine, Korea.
2Department of Rehabilitation Medicine, Rehabilitation Institute of Muscular Disease, Yonsei University College of Medicine, Korea. kswoong@yumc.yonsei.ac.kr
3Department of Neurology, Yonsei University College of Medicine, Korea.
뒤시엔느형 근디스트로피 환자에서 Sniff Nasal Inspiratory Pressure의 임상적 의의
장현정, 강성웅1, 박윤길1, 김완1, 유태원1, 이병인2
성균관대학교 의과대학 재활의학교실 및 임상의학연구소, 1연세대학교 의과대학 재활의학교실 및 근육병 재활연구소, 2연세대학교 의과대학 신경과학교실
Abstract
Objective
To evaluate sniff nasal inspiratory pressure (SNIP) in patients with Duchenne muscular dystrophy (DMD), to analyse the relationship SNIP and other pulmonary function test and to verify the usefulness of SNIP in patients with DMD.
Method
Twenty-seven patients with DMD who were able to follow commend were studied. Among them two patients were unable to perform maximal inspiratory pressure (MIP) mesurement. SNIP and MIP were measured using respiratory pressure meter in sitting position. Forced vital capacity (FVC) and peak cough flow (PCF) were evaluated using spirometer and peak flow meter respectively. The relationship between SNIP and other pulmonary function parame-ters were analysed.
Results
The mean value of SNIP was ⁣44.9 cmH2O (41.6% predicted) and the mean value of MIP was ⁣32.9 cmH2O (43.9% predicted). SNIP was correlated with MIP. When expressed absolute value, SNIP was higher than MIP in 23 of the 25 patients with DMD. SNIP and MIP were correlated with FVC. SNIP and MIP were correlated with PCF as well.
Conclusion
SNIP in patients with DMD is useful method to assess inspiratory muscle strength in addition to MIP and more easier to perform than MIP. (J Korean Acad Rehab Med 2006; 30: 632-638)
Key Words: Duchenne muscular dystrophy, Sniff nasal inspiratory pressure, Pulmonary function test, Respiratory muscle strength


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