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Journal of the Korean Academy of Rehabilitation Medicine 2007;31(2):143-149.
The Cross Effects of Needle Electrical Stimulation according to Electrode Placements on the Analgesia in Arthritic Rat Model.
Kim, Kyoung Yoon , Kim, Gye Yeop , Jung, Sung Hwan , Kim, Jae Hyung , Lee, Sam Gyu
1Department of Physical Medicine & Rehabilitation, Research Institutes of Medical Sciences, Chonnam National University Medical School, Korea. sam91@jnu.ac.kr
2Department of Physical Therapy, Dongshin University, Korea.
관절염 백서 모델에서 침전극 전기자극 부위에 따른 진통에 대한 교차 효과
김경윤1, 김계엽1, 정성환, 김재형, 이삼규
전남대학교 의과대학 재활의학교실 및 의과학연구소, 1동신대학교 물리치료학과
To investigate the analgesic effect of needle electrical stimulation (NES) according to the electrode placement in acute arthritic rat model.
Male Sprague-Dawley rats (120 rats, 250⁑50 g) were injected with a mixture of 3% carrageenan and 3% kaolin into the right knee joint. Rats were randomly assigned into one of four groups: Group I, control group (n=30); Group II, arthritic limb-induced control group (n=30); Group III, NES application group on the ipsilateral arthritic limb (n=30); Group IV, NES application group on the contralateral arthritic limb (n=30). We applied the NES (2 Hz, 200μs, 20 min) to group III and IV. We assessed the change of paw withdrawal latency (PWL) and the immunoreactivity of c-fos by immunohistochemistry at baseline, 4, 8, 12 and 24 hours after induction of arthritis.
NES was more effective in Group III and IV than group II 8 hours after the induction of arthritis (p<0.001) based on the results of PWLs and c-fos immunoreactivity. The analgesic effects of Group III were greater than those of group IV (p<0.001).
Contralateral NES on arthritic limb reduced pain in arthritic rat model as effectively as ipsilateral NES. (J Korean Acad Rehab Med 2007; 31: 143-149)
Key Words: Arthritis, Pain, Needle electrical stimulation, Immunohistochemistry, c-fos expression


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