Effects of Zoledronate on Thoracic Vertebral Fracture in an Ankylosing Spondylitis Patient: A case report.

, Kwak, Hyun; , Kim, Sang Beom; , Yoon, Kisung; , Lee, Kyeong Woo; , Kim, Bok; , Park, Gyu Tae

Case Report

Journal of the Korean Academy of Rehabilitation Medicine 2007;31(2):228-231.

Kwak, Hyun , Kim, Sang Beom , Yoon, Kisung , Lee, Kyeong Woo , Kim, Bok , Park, Gyu Tae

Department of Physical Medicine and Rehabilitation, Dong-A University College of Medicine, Korea. passnumber@hanmail.net

강직성 척추염 환자의 흉추 골절에서 졸레드로네이트의 효과 ⁣증례 보고⁣

곽현, 김상범, 윤기성, 이경우, 김원복, 박규태

동아대학교 의과대학 재활의학교실

Abstract

Patients with ankylosing spondylitis are more susceptible to spine fractures than healthy people. Because of their underlying back pain, vertebral fracture induced pain is not easily controlled by bed rest, physical therapy and medications. Thus, new treatment methods should be introduced. We report a 63 year-old man with ankylosing spondylitis who fell down 4 weeks ago and suffered a fracture of T6 spine. He complained of a mid thoracic pain. Although he was treated with bed rest, physical therapy, second-line bisphosphonate agents, the pain persisted. Therefore, intravenous zoledronate which was approved for palliative treatment of bone metastases in patients with breast cancer, 4 mg was administrated. The severity of pain was decreased by half within 2 days and sustained over 4 weeks. (J Korean Acad Rehab Med 2007; 31: 228-231)

Key Words: Vertebral fracture, Ankylosing spondylitis, Zoledronate