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Journal of the Korean Academy of Rehabilitation Medicine 2007;31(3):375-379.
Multiorgan Thrombotic Occlusions after Acitretin Treatment in a Patient with Chronic Psoriasis: A case report.
Yang, Chung Yong , Kim, Tae Jin , No, Se Eung , Joo, Min Cheol , Kil, Eun Young , Shin, Yong Il
1Department of Rehabilitation Medicine, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Korea. rehab@wonkwang.ac.kr
2Department of Rehabilitation Medicine, Wonkwang University School of Oriental Medicine, Korea.
건선 환자에서 아시트레틴 치료 중 발생한 다장기 혈전성 폐색증 1례 -증례 보고-
양충용, 김태진, 노세응, 주민철, 길은영1, 신용일
원광대학교 의과대학 재활의학교실 및 원광의과학연구소, 1한의과대학 재활의학교실
Psoriasis, whose symptom is shown in around 1∼3% American people, is a chronic and inflammatory skin disease. There are many treatments for pustular and erythrodermic psoriasis and oral retinoid which is a synthetic derivative of vitamin A is the most popular drug of them. Acitretin called as the second generation retinoid is a kind of active retinoid metabolite, which shows some drug toxicities in hepatic, skeletal and cardiovascular systems including atherosclerosis after a long term use. Even though that, we have just one case which has ever reported on acitretin-associated thrombotic stroke so far. We report a case on a patient who has multiorgan thrombotic occlusions resulted from longstanding psoriatic treatments by using acitretin for five years. This patient suffers from lots of complications such as superior mesenteric artery thrombosis, small cerebellar infarctions, cerebral infarction, acute renal failure concomitant with both small renal infarctions and atherosclerosis obliterans in his two legs. (J Korean Acad Rehab Med 2007; 31: 375-379)
Key Words: Acitretin, Thrombosis, Psoriasis


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