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Journal of the Korean Academy of Rehabilitation Medicine 2007;31(5):521-528.
The Effects of Growth Hormone on Quality of Life and Metabolism of Spinal Cord Injured Patients.
Kim, Sang Beom , Yoon, Kisung , Lee, Kyeong Woo , Kwak, Hyun , Lee, Jong Hwa
Department of Physical Medicine and Rehabilitation, Dong-A University College of Medicine, Korea. birddive@freechal.com
척수손상 환자의 삶의 질과 대사에 대한 성장호르몬의 효과
김상범, 윤기성, 이경우, 곽현, 이종화
동아대학교 의과대학 재활의학교실
Abstract
Objective
To evaluate the effects of growth hormone on metabolism and quality of life of spinal cord injured patients.
Method
Thirteen chronic spinal cord injured patients without metabolic and psychologic disorders except growth hormone deficiency were included in the study. They were randomly divided into two groups. Seven patients received growth hormone and six patients received distilled water as control. Before and after 6 months' administration, we measured Adult Growth Hormone Deficiency Assessment (AGHDA) and Psychological General Well-Being Index (PGWBI) for assessing quality of life. Bone mineral density (BMD), osteocalcin, urine deoxypyridinoline, % lean body mass, % body fat, body mass index (BMI) and lipid profile were also examined for assessing metabolic states.
Results
The AGHDA score decreased significantly from 6.7±2.9 to 3.9±2.1 (p<0.05), and the PGWBI score increased significantly from 81.7±14.8 to 88.7±8.7 (p<0.05) in growth hormone treatment group. There were no significant differences in control group. Other values about metabolic states were not significantly different in all groups.
Conclusion
Growth hormone was effective on improving quality of life in spinal cord injured patients, but there was no positive effect on metabolic values for short-term therapy. (J Korean Acad Rehab Med 2007; 31: 521-528)
Key Words: Growth hormone, Spinal cord injury, Quality of life, Metabolism


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