| The Effect of Midodrine on Exercise-induced Hypotension in Cervical Cord Injury Patients. |
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Jung, Hyun , Seo, Jeong Hwan , Ko, Myoung Hwan , Park, Sung Hee , Sim, Young Joo |
1Department of Physical Medicine and Rehabilitation, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Korea. vivaseo@chonbuk.ac.kr
2Department of Physical Medicine and Rehabilitation, Kosin University College of Medicine, Korea. |
| 경수 손상에서 운동 후 저혈압에 대한 Midodrine의 효과 |
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정현, 서정환, 고명환, 박성희, 심영주1 |
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전북대학교 의과대학 재활의학교실, 1고신대학교 의과대학 재활의학교실 |
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| Abstract |
Objective
To evaluate the effect of midodrine, an Ձ1 agonist, on symptom and hemodynamic response during standing and arm bicycle ergometer exercise in patients with cervical cord injury.
Method
Twelve cervical spinal cord injury patients with orthostatic hypotension symptoms and post-exercise hypo- tension were enrolled. They were positioned on a 90° standing frame for 3 minutes. After 15 minutes of resting on supine position, 5 minutes of arm bicycle ergometer exercise was done. These tests were done without midodrine initially, but, with 5 mg midodrine on the next day. Heart rate, self-perceived presyncope score (PPS), systolic and diastolic blood pressure were measured before, during and after the exercise.
Results
With 5 mg midodrine, the decrease of systolic and diastolic blood pressures after 3 minutes' standing was significantly smaller than without midodrine (p＜0.05). PPS was also significantly decreased with midodrine on standing frame test. Arm ergometer exercise induced less systolic blood pressure decrease and better PPS on immediate and 5 minutes after exercise with midodrine (p＜0.05). The change of diastolic blood pressure and heart rate was not significant after the exercise with midodrine.
Conclusion
In cervical spinal cord injury patients with orthostatic and post-exercise hypotension, 5 mg midodrine significantly improved the symptoms and the systolic blood pressures. (J Korean Acad Rehab Med 2008; 32: 45-50) |
| Key Words:
Midodrine, Post-exercise hypotension, Cervical cord injury |
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