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Journal of the Korean Academy of Rehabilitation Medicine 2008;32(3):247-252.
Comparison of the Effects between Growth Hormone and Hyaluronic Acid on Degenerative Cartilage of Knee in Rabbit.
Kim, Sang Beom , Lee, Kyeong Woo , Ha, Nam Jin , Lee, Jong Hwa , Kim, Young Dong , Joe, Yang Lae , Kim, Dae Chul
1Department of Physical Medicine and Rehabilitation, Dong-A University College of Medicine, Korea. kelee65@dau.ac.kr
2Department of Pathology, Dong-A University College of Medicine, Korea.
가토 퇴행성 관절염에서 성장호르몬과 히알루론산의 효과 비교
김상범, 이경우, 하남진, 이종화, 김영동, 조양래, 김대철1
동아대학교 의과대학 재활의학교실, 1병리학교실
To explore whether the growth hormone is effective in the treatment of degenerative cartilage of knee in rabbits.
Thirty New Zealand white rabbits were administered intra-articular injection with monosodium iodoacetate (Sigma, St. Louis, USA) 2.5 mg and divided into 3 groups. Each group was administered with hyaluronic acid (Hyruan plus, LG life science, Seoul, Korea)(group A) 0.6 ml, growth hormone (Declage, LG life science, Seoul, Korea) (group B) or saline (group C) 0.6 ml intra-articulary once a week for 4 weeks, beginning 4 weeks after the degeneration induction. All rabbits were killed 9 weeks after degeneration induction. The histologic morphology was observed by optical microscope with knee cartilage.
Mankin score was 2.4±1.3 in group A, 3.9±1.7 in group B, 7.4±0.8 in group C. Yoshimi score was 1.5±0.7 in group A, 2.2±0.9 in group B, 4.4±0.6 in group C. Gross and microscopic morphologic findings showed that group C represented the more severe than group A & B (p<0.01), also group A was better than group B (p<0.05).
Growth hormone is effective on degenerative knee cartilage in rabbit model, but less than the hyaluronic acid. (J Korean Acad Rehab Med 2008; 32: 247-252)
Key Words: Growth hormone, Hyaluronic acid, Degenerative cartilage of knee


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