Effect and Safety of Oral Desmopressin for Nocturia in Brain Injured Patients.

, Choi, Soo Won; , Song, Wonu; , Kim, Wanho; , Kim, Eun Joo; , Kim, Jong Hoon; , Yang, Ho Cheol; , Kim, Han Na

Original Article

Journal of the Korean Academy of Rehabilitation Medicine 2008;32(3):267-272.

Choi, Soo Won , Song, Wonu , Kim, Wanho , Kim, Eun Joo , Kim, Jong Hoon , Yang, Ho Cheol , Kim, Han Na

Department of Rehabilitation Medicine, National Rehabilitation Center, Korea. love575dr@naver.com

뇌손상 환자의 야간뇨에 대한 경구 데스모프레신의 효과 및 안전성

최수원, 송원우, 김완호, 김은주, 김종훈, 양호철, 김한나

국립재활병원 재활의학과

Abstract

Objective
To assess the effect of oral desmopressin administration for nocturia and sleeping in brain injured patients and to confirm its safety.
Method
20 brain injured patients waking up more than twice a night for urination during sleeping have been subjected to take 0.1 mg of desmopressin at 9 p.m. everyday for 30 days. To analyze the effect of the drug before and after its administration, the frequency of patient's awakening for urination, duration of time to first urination after sleeping, total urination volume during sleeping and Pittsburgh sleep quality index (PSQI) were evaluated. All newly found symptoms one month after taking the medication were recorded to confirm the safety of the drug.
Results
After taking the medication, the mean urination frequency of 20 patients was reduced from 2.4 to 1.4, the mean duration of time to the first urination after sleeping was increased from 3.4 hours to 4.9 hours (p＜0.01). The mean PSQI score of 20 patients was decreased from 9.7 to 4.8 (p＜0.01). 2 patients had side effects (hyponatremia, headache).
Conclusion
The oral administration of desmopressin was relatively safe and effective on brain injured patients with nocturia. (J Korean Acad Rehab Med 2008; 32: 267-272)

Key Words: Desmopressin, Nocturia, Brain, Sleep