J Korean Acad Rehabil Med Search


Journal of the Korean Academy of Rehabilitation Medicine 2008;32(3):267-272.
Effect and Safety of Oral Desmopressin for Nocturia in Brain Injured Patients.
Choi, Soo Won , Song, Wonu , Kim, Wanho , Kim, Eun Joo , Kim, Jong Hoon , Yang, Ho Cheol , Kim, Han Na
Department of Rehabilitation Medicine, National Rehabilitation Center, Korea. love575dr@naver.com
뇌손상 환자의 야간뇨에 대한 경구 데스모프레신의 효과 및 안전성
최수원, 송원우, 김완호, 김은주, 김종훈, 양호철, 김한나
국립재활병원 재활의학과
To assess the effect of oral desmopressin administration for nocturia and sleeping in brain injured patients and to confirm its safety.
20 brain injured patients waking up more than twice a night for urination during sleeping have been subjected to take 0.1 mg of desmopressin at 9 p.m. everyday for 30 days. To analyze the effect of the drug before and after its administration, the frequency of patient's awakening for urination, duration of time to first urination after sleeping, total urination volume during sleeping and Pittsburgh sleep quality index (PSQI) were evaluated. All newly found symptoms one month after taking the medication were recorded to confirm the safety of the drug.
After taking the medication, the mean urination frequency of 20 patients was reduced from 2.4 to 1.4, the mean duration of time to the first urination after sleeping was increased from 3.4 hours to 4.9 hours (p<0.01). The mean PSQI score of 20 patients was decreased from 9.7 to 4.8 (p<0.01). 2 patients had side effects (hyponatremia, headache).
The oral administration of desmopressin was relatively safe and effective on brain injured patients with nocturia. (J Korean Acad Rehab Med 2008; 32: 267-272)
Key Words: Desmopressin, Nocturia, Brain, Sleep


Browse all articles >

Terms of Use   |   Privacy Polity
Editorial Office
Department of Rehabilitation Medicine, Seoul National University Hospital
101 Daehak-ro, Jongno-gu, Seoul, Korea
Tel: +82-10-8678-2671    Fax: +82-2-6072-5244    E-mail: edit@e-arm.org; edit.karm@gmail.com
Business Registration: 110-82-07460                

Copyright © 2024 by Korean Academy of Rehabilitation Medicine.

Developed in M2PI

Close layer