Teicoplanin-induced Elevation of Plasma Creatine Phosphokinase in the Patient with Wound Infection: A case report.

, Park, Geun Young; , Park, Joo Hyun; , Kim, Yun Hee; , Kim, Sae Hyun; , Yang, Byung Woo

Case Report

Journal of the Korean Academy of Rehabilitation Medicine 2008;32(4):469-471.

Park, Geun Young , Park, Joo Hyun , Kim, Yun Hee , Kim, Sae Hyun , Yang, Byung Woo

Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Korea. rokin98@catholic.ac.kr

욕창 감염 환자에서 Teicoplanin 사용에 의한 혈중 크레아틴인산활성효소의 증가 1례 -증례 보고-

박근영, 박주현, 김윤희, 김세현, 양병우

가톨릭대학교 의과대학 재활의학교실

Abstract

The use of teicoplanin is increasing with increase in the incidence of wound infections caused by methicillin-resistant Staphylococcus aureus. Teicoplanin has longer half-life than vancomycin, so it can be administerd once daily, whereas vancomycin has to be administered 3∼4 times daily. Teicoplanin is known to have lesser side effect profiles than vancomycin, such as skin eruptions, ototoxicity and nephrotoxicity. A 27-year old women in vegetative state had a grade 3 pressure sore at coccyx area. We prescribe teicoplanin to manage wound infected by methicillin-resistant Staphylococcus aureus. Plasma creatine phosphokinase (CPK) was elevated abruptly at 9th day of teicoplanin therapy. Five days after discontinuation of teicoplanin, CPK was normalized. We experienced a case of elevation of plasma creatine phosphokinase associated with teicoplanin. (J Korean Acad Rehab Med 2008; 32: 469-471)

Key Words: Teicoplanin, Creatine phosphokinase (CPK), Pressure sore