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Journal of the Korean Academy of Rehabilitation Medicine 2008;32(5):501-505.
Effect of Prefrontal Repetitive Transcranial Magnetic Stimulationon the Enhancement of Working Memory.
Ohn, Suk Hoon , Park, Chang Il , Lee, Bo Hyun , Kim, Yun Hee
1Department of Physical Medicine and Rehabilitaion, Stroke and Cerebrovascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea. yun1225.kim@samsung.com
2Department and Research Institude of Rehabilitation Medicine, Yonsei University College of Medicine, Korea.
전두엽부 반복경두개자기자극의 작업기억력 증진효과
온석훈, 박창일1, 이보현, 김연희
성균관대학교 의과대학 삼성서울병원 재활의학교실 및 뇌졸중센터, 1연세대학교 의과대학 재활의학교실 및 재활의학연구소
To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) applied over the left prefrontal cortex on the enhancement of verbal working memory in healthy persons.
High frequency (10 Hz) rTMS was applied over the left prefrontal cortex with the intensity of 100% resting motor threshold (RMT). A 3-back verbal working memory task was administered before, during (after applying 500 and 1,000 pulses, respectively), and 30 minutes after real or sham rTMS.
Real rTMS, compared with sham stimulation, significantly improved working memory performance. Accuracy of response increased significantly after applying 1,000 pulses of real rTMS (p<0.05). This effect maintained for 30 minutes after completion of stimulation (p<0.05). The error rate and reaction time did not change with rTMS. There was no noticeable side effect during or after rTMS.
1,000 pulses of 10 Hz rTMS administered to the left prefrontal cortex with the intensity of 100% RMT have positive impact on verbal working memory in healthy persons. Further study is necessary to address this effect of rTMS in patients with cognitive dysfunction. (J Korean Acad Rehab Med 2008; 32: 501-505)
Key Words: Repetitive transcranial magnetic stimulation, Working memory, Prefrontal cortex


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