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Journal of the Korean Academy of Rehabilitation Medicine 2008;32(5):527-532.
The Correlations between Pulse Pressure and Functional Outcomein Acute Middle Cerebral Arterial Ischemic Stroke.
Jang, In Sub , Shin, A Young , Cho, Yun Mi , Ryu, Su Ra , Han, Jae Young , Choi, In Sung , Kim, Jae Hyung , Lee, Sam Gyu
Department of Physical and Rehabilitation Medicine, Research Institute of Medical Sciences, Chonnam National University Medical School, Korea. LEE9299@hitel.net
급성 중대뇌동맥 뇌경색에서 초기 맥박압 상승과 기능 예후의 상관성
장인섭, 신아영, 조윤미, 류수라, 한재영, 최인성, 김재형, 이삼규
전남대학교 의과대학 재활의학교실 및 의과학연구소
Abstract
Objective
To investigate the correlation between the pulse pressure (PP) and functional outcome in acute middle cerebral arterial (MCA) ischemic stroke.
Method
We reviewed the medical records of 52 first-ever hemiplegic MCA ischemic stroke patients (age 61.5±9.7 years; 35 men, 17 women). Functional outcomes were evaluated with Korean-modified Barthel index (K-MBI), functional independence measure (FIM), Korean-national institutes of health stroke scale (K-NIHSS), and Korean-mini mental state examination (K-MMSE) on 3 days and 3 months after the onset of stroke in all the subjects. The PP was measured six times within initial 24 hours after stroke onset and then the highest PP was selected for the analysis.
Results
The degree of PP elevation revealed the significant correlations with male gender, over the age of 55 years, diabetes mellitus, and current smoking history, respectively (p<0.05). In TOAST (Trial Org 10172 in Acute Stroke Treatment) classification, the large artery atherosclerosis group showed significantly the higher PP rather than the other groups (p<0.05). There were inverse correlations between the PP and each of FIM and K-MBI scores on 3 months after stroke onset (p=0.000, 0.009; r=−0.479, −0.358). There was an inverse correlation between the PP and the change of FIM (p=0.000, r=−0.532).
Conclusion
The PP within initial 24 hours after stroke onset revealed significant correlation with functional outcome. The management for the proper PP gives the favorable effect on the functional outcome in acute MCA territory ischemic stroke. (J Korean Acad Rehab Med 2008; 32: 527-532)
Key Words: Pulse pressure, Outcome, Middle cerebral artery, Hemiplegia, Stroke


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