Changes in Evoked Potentials in Focal Cerebral Cortical Ischemia in the Rat.

, Lee, Seong Jae; , Park, Won Beom; , Chae, Sanghan; , Lee, Young Il; , Kim, Tae Uk

Original Article

Journal of the Korean Academy of Rehabilitation Medicine 2009;33(2):147-153.

Lee, Seong Jae , Park, Won Beom , Chae, Sanghan , Lee, Young Il , Kim, Tae Uk

¹Department of Rehabilitation Medicine, Dankook University College of Medicine, Korea. rmlee@dankook.ac.kr
²Department of Anatomy, Dankook University College of Medicine, Korea.

흰 쥐의 국소성 피질성 뇌경색 모델에서 관찰되는 유발전위의 변화

이성재.박원범.채상한.이영일1.김태욱

단국대학교 의과대학 재활의학교실, 1해부학교실

Abstract

Objective
To investigate the changes of motor and soma-tosensory evoked potentials found in focal cerebral cortical ischemia induced by endothelin-1 (ET-1), one of the common models of cerebral infarct in rats.
Method
A total of twenty Sprague-Dawley rats were studied. Focal cerebral cortical ischemia was induced by steterotaxic injection of ET-1 into forelimb region of cerebral cortex. Pellet retrieval test, motor evoked potential (MEP), and somatosensory evoked potential (SEP) were compared before and after cerebral ischemia. The location and extent of cerebral ischemia were confirmed histologi-cally.
Results
Success rate of pellet retrieval test decreased significantly after induction of cerebral ischemia, demon-strating sensorimotor deficit in the contralateral forelimb. The latency and amplitude of MEP did not changed significantly despite weakness of forelimb. However, SEP showed reversal of the positive peaks.
Conclusion
The results suggest that the changes of MEP and SEP in focal cerebral cortical ischemia are different from those in cerebral ischemia by large artery occlusion. When evaluating MEP and SEP in focal cerebral ischemia model, interpretation of evoked potentials should be cautious. (J Korean Acad Rehab Med 2009; 33: 147-153)

Key Words: Brain ischemia, Evoked potentials, Endothelin-1, Animal model, Rats