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Journal of the Korean Academy of Rehabilitation Medicine 2009;33(3):316-320.
Relationship between Respiratory Muscle Strength and Cardiac Function in Duchenne Muscular Dystrophy.
Kang, Seong Woong , Shin, Hyun Joon , Im, Sang Hee , Lee, Sang Chul , Chang, Won Hyuk , Kim, Yong Kyun , Kim, Jong Chan
1Department of Rehabilitation Medicine and Rehabilitation Institute of Muscular Disease, Yonsei University College of Medicine, Korea.
2Department of Cardiology, Yonsei University College of Medicine, Korea.
3Department of Rehabilitation Medicine, College of Medicine, Cheju National University, Korea.
4Department of Physical Medicine and Rehabilitation, Myongji Hospital, Kwandong University College of Medicine, Korea. bettertomo@naver.com
두시엔느 근디스트로피 환자에서 호흡근 근력과 심장기능 간의 연관성
강성웅, 신현준1, 임상희2, 이상철3, 장원혁, 김용균3, 김종찬
연세대학교 의과대학 재활의학교실 및 근육병 재활연구소, 1심장내과학교실, 2제주대학교 의과대학 재활의학교실, 3관동대학교 의과대학 명지병원 재활의학교실
To investigate the relationship between respiratory muscle strength and cardiac function in patients with Duchenne muscular dystrophy (DMD).
This study included 37 patients with DMD. Cardiac function of patients was evaluated by thoracic echocardiography, which recorded left ventricular ejection fraction (LVEF). Maximal expiratory pressure (MEP) and maximal inspiratory pressure (MIP) representing respiratory muscle strength and blood sampling for brain natriuretic peptide (BNP) were performed.
LVEF did not show significant correlation with MIP, MEP or age. However, LVEF was negatively correlated with BNP level.
Cardiac dysfunction of patients with DMD didn't correlate with age or respiratory muscle strength. Therefore, investigation of cardiac function itself is needed for patients with DMD irrespective of respiratory compromises. (J Korean Acad Rehab Med 2009; 33: 316- 320)
Key Words: Duchenne muscular dystrophy, Respiratory muscle, Ejection fraction, Brain natriuretic peptide


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