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Journal of the Korean Academy of Rehabilitation Medicine 2009;33(5):507-513.
Effect of Cerebral Motor Cortex Stimulation in Amyotrophic Lateral Sclerosis Model: A Preliminary Controlled Study.
Lee, Jin Hoon , Song, Jae Eun , Moon, Seong Keun , Kim, Hyoung Ihl , Kim, Hyo Joon , Shin, Jin Hee , Shin, Yong Il
1Department of Rehabilitation Medicine and Institute of Medical Science, Wonkang University School of Medicine, Korea. cbrmshin@wku.ac.kr
2Department of Neurosurgery, Wonkang University School of Medicine, Korea.
3Department of Neurosurgery, Presbyterian Medical Center, Korea.
4Research Institute for Neural Science and Technology, Ajou University School of Medicine, Korea.
근위축성 측색경화증 모델에서 대뇌 운동 피질 전기자극치료의 효과: 예비연구
이진훈, 송재은, 문성근1, 김형일2, 김효준2, 신진희3, 신용일
원광대학교 의과대학 재활의학교실 및 의과학연구소, 1신경외과학교실, 2예수병원 신경외과, 3아주대학교 신경과학기술연구소
To observe the effect of the depolarizing stimulation in amyotrophic lateral sclerosis (ALS) mouse model on the survival and behavioral performance.
Transgenic male mouse model of ALS at the age of 9∼11 weeks were divided into sham control group (n=10) and stimulation group (n=9). Electrode was implanted in the motor cortex in left hemisphere. Movement thresholds (MT) were regularly checked. Half threshold of MT, unipolar, and continuous electrical stimulation (frequency, 50 Hz; pulse duration, 220Ռs) was delivered through implanted electrode. Behavioral tests including Rota-rod and Paw-grip endurance were checked every day.
Induction of symptom was delayed in 8 days in stimulation than sham control group. However, there was no significant difference in survival in both groups. Behavioral tests showed that stimulation group is significantly better than sham group in Rota-rod (11∼15 weeks) and in grip endurance (11∼14, 16 weeks). MT was always between 1.0 volt and 3.2 volt in sham group, however, MT was between 0.8 volt and 2.8 volt in stimulation group. MT was jumped up around the time of death in both groups.
Electrical stimulation is considered to be one of possible trial methods in ALS model. However, parameters of the stimulation in the experiment should be modified for better results. (J Korean Acad Rehab Med 2009; 33: 507-513)
Key Words: Amyotrophic lateral sclerosis, Motor cortex stimulation, Rota-rod test, Paw-grip endurance, Survival


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