Objective
To test the feasibility and usability of an artificial intelligence (AI)-guided mobile cognitive telerehabilitation program for patients with stroke or older adults with mild cognitive impairment (MCI).
Methods
Thirteen participants with cognitive impairment (Mini-Mental State Examination [MMSE] score≤26; nine with stroke and four with MCI) were enrolled in the study. Each participant was provided with an AI-guided mobile cognitive rehabilitation program (Zenicog®). Participants were instructed to complete 24 sessions within 6 weeks, and those with sufficient adherence (≥70%, 17 sessions) were included in the analysis. Cognitive assessments included the MMSE, digit span, and Trail Making Tests A & B. The usability questionnaire investigated equitable use and flexibility in use, simple and intuitive use, perceptible information, tolerance for error, low physical effort, size and space for use, overall product quality, overall satisfaction.
Results
Eleven participants completed the study, and 10 participants met adherence criteria. The MMSE score increased significantly from 24.00 [21.00, 25.75] at baseline to 27.50 [26.00, 28.75] after intervention. The overall product quality (Likert scale: 1–5) score was 4.00±0.87. The lowest score in the usability questionnaire was for tolerance for error. Female participants and participants with <12 years’ education gave lower scores for tolerance for error and equitable/ flexibility in use, respectively.
Conclusion
The AI-guided mobile cognitive telerehabilitation program is feasible and potentially beneficial for improving cognitive function in patients with stroke or older adults with MCI. Individuals who are less familiar with electronic devices require special consideration to improve their usability.

Objective
To compare the efficacy, safety, and patient compliance of tele-cardiac rehabilitation (T-CR) versus center-based cardiac rehabilitation (C-CR) in patients with coronary artery disease (CAD). A secondary aim was to assess the effects of both interventions on quality of life (QoL) and kinesiophobia.
Methods
This nonrandomized, patient-preference controlled trial included 40 CAD patients (83% post-myocardial infarction) at a university hospital. Participants selected either C-CR or T-CR. The four-week intervention included supervised in-hospital exercise (C-CR) or telemonitored exercise with heart rate feedback (T-CR). The primary outcome was peak oxygen uptake (VO2 peak). Secondary outcomes included VO2 at ventilatory anaerobic threshold (VO2 at VAT), time to VAT, oxygen pulse, QoL, Fear of Activity in Patients with Coronary Artery Disease (Fact-CAD) scores, and exercise adherence.
Results
Baseline VO2 peak was higher in the T-CR group (23.2±3.5 vs. 19.4±4.2, p=0.004). Rehabilitation improved VO2 peak (p<0.001), VO2 at VAT (p=0.004), and time to VAT (p<0.001) in both groups. Fact-CAD scores decreased (p=0.004), and QoL improved (p<0.001). However, C-CR led to greater kinesiophobia reduction (p=0.038) and slightly higher QoL improvements (p=0.05). T-CR participants completed more exercise sessions (14.9±2.9 vs. 12.0±0, p<0.001), with no serious adverse events reported.
Conclusion
T-CR is a safe and effective alternative to C-CR, providing similar physiological benefits. However, C-CR may be superior in reducing kinesiophobia. Future studies should assess long-term adherence and psychological outcomes in diverse populations.

Objective
To examine the effect of the telerehabilitation program on sleep quality and fatigue level in patients with multiple sclerosis (MS) was aimed in this study. MS is a demyelinating disease defined by various signs and symptoms that affects physical, emotional, social, and cognitive functioning. Fatigue, depression, sleep disturbance and cognitive impairment are the among common symptoms of MS.
Methods
The study implemented an individual exercise program for twice a week for 12 weeks via telerehabilitation. In the home-based video exercise group, the same exercises were given as video recordings and the patients were asked to do the exercises twice a week for 12 weeks. Pittsburgh Sleep Quality Index (PSQI), Fatigue Severity Scale (FSS), Multiple Sclerosis Quality of Life Scale-54 and Timed 25 Foot Walk Test were used in the evaluation. The trial is registered with the number of NCT04979845 on ClinicalTrials.gov.
Results
PSQI scores changed from 5.6 (2.1) to 3.66 (2.09) in telerehabilitation group (p=0.03) while no significant change were seen in the video exercise group. Similarly FSS scores decreased from 4.37 (1.42) to 3.67 (1.68) in telerehabilitation group (p=0.04) while no significant changes were seen in the video based exercise group.
Conclusion
The telerehabilitation program is thought to be an effective and accessible non-pharmacological application that can be used in the treatment of sleep quality and fatigue in individuals with MS.

Citations

• FATIGUE IN MULTIPLE SCLEROSIS – MECHANISMS, DIAGNOSIS, AND TREATMENT OPTIONS
  Kornelia Kaźmierkiewicz-Makanga, Weronika Spychalska, Emilia Piotrowicz, Filip Witowicz, Julia Glińska, Aleksandra Krawczyk, Wiktoria Waldon, Paulina Sumlet, Maria Gofron, Michał Duliński
  International Journal of Innovative Technologies in Social Science.2025;[Epub]     CrossRef

Objective
To examine the impact of telerehabilitation training on exercise capacity, lung function, and health-related quality of life (HRQOL) in comparison to no rehabilitation for post-COVID-19 symptoms in adult females.
Methods
A randomized controlled trial of 48 females after mild to moderate COVID-19 survival were equally and randomly assigned to one of two groups: intervention group or control group. Three sessions per week for 6 weeks of a telerehabilitation program provided via a smartphone to the intervention group. Spirometry was used to quantify lung function, a 6-minute walk test (6MWT) measured in meters to measure exercise capacity, and the Short Form Health Survey-36 was used to assess HRQOL.
Results
After treatment, there was no statistically significant difference in forced vital capacity (FVC) or forced expiratory volume in 1 second (FEV₁) between groups (p>0.05), but the 6MWT of the intervention group increased significantly more than that of the control group (p=0.001). The percent of change in 6MWT for the intervention group and control group was 14.22% and 4.21%, respectively. After therapy, the intervention group’s HRQOL significantly improved when compared to the control group’s (p=0.001).
Conclusion
This study showed that a telerehabilitation programs improved exercise capacity and HRQOL in young females post-COVID-19 compared to no rehabilitation.

Citations

• Overview of outcomes measurement tools used to evaluate outpatient and home-based exercise-based pulmonary rehabilitation programs for COVID-19: A systematic review
  Fabrice Gambaraza, Germain Perrin, Sven Günther, Virginie Korb-Savoldelli, Anne-Isabelle Tropeano, Thibaut Caruba, Sarah Berdot, Brigitte Sabatier
  Health Sciences Review.2026; 18: 100262.     CrossRef
• The effectiveness of the AI-based RehabLung mobile rehabilitation system on cardiopulmonary function and user satisfaction in lung cancer patients undergoing thoracic surgery: a protocol for a two-arm randomized clinical trial
  Hsin-Lun Yang, Ching-Hsia Hung, Yu-Ting Huang, Hui-Ching Cheng, Yau-Lin Tseng, Jun-Ming Su, Kun-Ling Tsai
  Therapeutic Advances in Respiratory Disease.2026;[Epub]     CrossRef
• Physical Therapy Outcome Measures Used in Persons With Long Covid: A Systematic Review of Interventional Studies Up to 1-Year Postglobal Health Emergency
  Andrea Lopes Sauers, Liana Johnson, Marissa Mortensen, Laura Bianca Dorásio da Silva, Luciana Angélica da Silva de Jesus, Jaime González, Cristino Oliveira
  Cardiopulmonary Physical Therapy Journal.2025; 36(2): 105.     CrossRef
• Efficacy of Telerehabilitation Protocols for Improving Functionality in Post-COVID-19 Patients
  Jose Luis Estela-Zape, Valeria Sanclemente-Cardoza, Leidy Tatiana Ordoñez-Mora
  Life.2025; 15(1): 44.     CrossRef
• Advances in home-based respiratory muscle training for improving physical function in older adults with long COVID
  Xu Guo, Xuemei Li
  Frontiers in Physiology.2025;[Epub]     CrossRef
• The effect of pulmonary rehabilitation for post-acute sequelae of SARS-CoV-2 infection in patients: a systematic review and meta-analysis
  Yinghua Yue, Xinyi Han, Qiming Chen, Lirong Dai, Qingjuan Ai, Zhigang Zhang, Fangli Ma, Jing Gao
  Frontiers in Rehabilitation Sciences.2025;[Epub]     CrossRef
• REHABILITATION IN PERSISTENT EFFECTS OF COVID-19 INFECTION REVIEW: IMPORTANCE OF TELE-REHABILITATION, INTEGRATED MULTIDISCIPLINARY APPROACH
  Kamil Franczyk, Wojciech Machulski, Karolina Świerk, Damian Podkościelny, Jan Krzysztof Makulski, Adam Januszkiewicz, Wiktoria Januszkiewicz, Maria Gierasimiuk, Michał Górski, Martyna Ciarkowska
  International Journal of Innovative Technologies in Social Science.2025;[Epub]     CrossRef
• Practical Recommendations for Exercise Training in Patients with Long COVID with or without Post-exertional Malaise: A Best Practice Proposal
  Rainer Gloeckl, Ralf H. Zwick, Ulrich Fürlinger, Tessa Schneeberger, Daniela Leitl, Inga Jarosch, Uta Behrends, Carmen Scheibenbogen, Andreas Rembert Koczulla
  Sports Medicine - Open.2024;[Epub]     CrossRef
• Effectiveness of telerehabilitation in patients with post-COVID-19: a systematic review and meta-analysis of randomised controlled trials
  Jiang Yang, Huiru Li, Hulei Zhao, Yang Xie, Jiansheng Li, Minghang Wang
  BMJ Open.2024; 14(7): e074325.     CrossRef
• Effectiveness of telerehabilitation versus face-to-face pulmonary rehabilitation on physical function and quality of life in people with post COVID-19 condition: a systematic review and network meta-analysis
  Oliver MARTÍNEZ-POZAS, Camilo CORBELLINI, Juan N. CUENCA-ZALDÍVAR, Érika MELÉNDEZ-OLIVA, Pierluigi SINATTI, Eleuterio A. SÁNCHEZ ROMERO
  European Journal of Physical and Rehabilitation Medicine.2024;[Epub]     CrossRef