Annals of Rehabilitation Medicine

"Protein S"

Case Reports

Multivessel Thromboembolism Associated with Dysfunction of Protein S: Eun Jae Ok, Hye Won Kim, Sang Dong Kim, Kyoung Soo Park, Yang Soo Kim, Ha Min Kim, Seong Hoon Lim; Ann Rehabil Med 2012;36(3):414-417. Published online June 30, 2012; DOI: https://doi.org/10.5535/arm.2012.36.3.414

Abstract
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Protein S is a vitamin K-dependent coagulation factor that acts as an anticoagulant. Deficiency of protein S increases the risk of thromboembolic events. We report a case of isolated protein S deficiency in a 39-year-old woman suffering arterial occlusion in both lower legs. She underwent a surgical procedure using thrombectomy and balloon angioplasty of her left lower extremity. Later, she had right trans-tibial amputation because of the reperfusion injury. Throughout the evaluation of thromboembolic events, we diagnosed a large thrombus in the right atrium and an asymptomatic pulmonary thromboembolism. The patient was successfully treated with right atrial thrombectomy and systemic anticoagulation. Careful evaluation for protein S levels may be necessary in patients with arterial thromboembolic events, especially young adults.

Citations

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A Rare Case of Left Atrial Mass with Nonhemorrhagic Infarct in a Patient of Inherited Thrombophilia
Gurinder Mohan, Hargurdas Singh, Jivtesh Preet Singh, Akansha LNU, Kapeesh Khanna
AMEI's Current Trends in Diagnosis & Treatment.2022; 5(2): 107. CrossRef
Central retinal vein occlusion as a presenting feature in a young patient with protein S deficiency
Rupak Roy, Kumar Saurabh, Amit B Jain, Debmalya Das, Anindya K Majumder, Aneesha Lobo
Clinical and Experimental Optometry.2015; 98(2): 190. CrossRef

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Paradoxical Cerebral Embolism in a Young Patient: A case report.: Lee, Hee Dea , Sung, Duk Hyun; J Korean Acad Rehabil Med 2005;29(5):527-530.

Abstract
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Seventeen years old man was diagnosed as left calf varicous vein and deep vein thrombosis on the same area. Three years later the patient visited for the exasperated swelling but had no sufficient warfarin therapy. At the age of 24, the patient had abrupt onset of left hemiplegia. Risk factor was monitored and patent foramen ovale and protein S deficiency were diagnosed. Simultaneously pulmonary embolism was detected and inferior vena cava filter was inserted. Nine months later from stroke, the patient had several times neurolysis on left lower extremity for spasticity. But after three days from last neurolysis we detected aggravation of lower extremity and left upper extremity swelling. He continued anticoagulation therapy. We reported a young patient with cerebral infarction by the mechanism of paradoxical embolism and upper extremity deep vein thrombosis in the lack of anticoagulation medication. (J Korean Acad Rehab Med 2005; 29: 527-530)