To evaluate intra-tester reliability of P300 more precisely, this study was designed. Event-related potential (ERP) is the result of endogenous brain response following cognitive stimulus. The P300 component of the human ERP is a positive wave with a latency of 300 ms or greater. Our purpose of this study was to estimate reliability of P300 latency and amplitude with 30 normal persons without head injury, as well as to set up them as the reference values in the event that they would be found to be highly reliable.
ERP was performed at three separate times on 30 normal adults in their 20s and 30s. We measured P300 latency and amplitude among ERP.
P300 latency show excellent reliability with intraclass correlation coefficient (ICC) of 0.81. As to P300 amplitude, reliability was good to fair with ICC of 0.53. Average value of P300 latency was 311.3±37.0 ms, shorter than reference value of previous study in Korea.
P300 latency revealed higher reliability than P300 amplitude, although reliability of P300 was confirmed in both component. After further study including precise mechanism, influence factor on measurement and method standardization, it is expected to be an objective indicator to assess the cognitive state and predict prognosis.
Citations
Objective: To investigate the correlation between age and P3 parameters of the latency, amplitude, and reaction time, and to assess the changes of parameters in heathy volunteers after the manual stimulation of an acupoint He-7 which is used to treat convulsive disorder, anxiety and insomnia, and of a non-acupuncture point.
Method: The P3 studies using an auditory paradigm and requiring a button press to infrequently occurring tones were performed in 36 healthy persons with age range from 21 to 72 years. The studies were repeated after the manual stimulation of an acupoint He-7 for 10 minutes and of a nonacupoint for 15 or 20 minutes afterwards.
Results: The mean P3 latency was 355.1⁑31.4 msec and reaction time was 691.4⁑139.7 msec. Significant correlations were seen between the age and P3 reaction time as well as latency. Considerable increase of P3 amplitude was observed after the stimulation of an acupoint He-7.
Conclusion: The results of this study suggest that the P3 latency and reaction time are sensitive to age and the reaction from an acupoint He-7 stimulation may be related to the neuromodulation of noradrenaline or endorphine.
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