Annals of Rehabilitation Medicine

"Ossification of the posterior longitudinal ligament"

Original Articles

The Insertion/Deletion Polymorphism of Angiotensin I Converting Enzyme Gene is Associated With Ossification of the Posterior Longitudinal Ligament in the Korean Population: Dong Hwan Kim, Dong Hwan Yun, Hee-Sang Kim, Seong Ki Min, Seung Don Yoo, Kyu Hoon Lee, Ki-Tack Kim, Dae Jean Jo, Su Kang Kim, Joo-Ho Chung, Ju Yeon Ban, Sung Yong Lee; Ann Rehabil Med 2014;38(1):1-5. Published online February 25, 2014; DOI: https://doi.org/10.5535/arm.2014.38.1.1

Abstract
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Objective

To determine whether ACE insertion/deletion (I/D) polymorphism is associated with the ossification of the posterior longitudinal ligament (OPLL) of the spine in the Korean population.

Methods

A case-control study was conducted to investigate the association between I/D polymorphism of the angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ACE) gene and OPLL. The 95 OPLL patients and 274 control subjects were recruited. Polymerase chain reaction for the genotyping of ACE I/D polymorphism was performed. The difference between the OPLL patients and the control subjects was compared using the contingency χ² test and the logistic regression analysis. For statistical analysis, SPSS, SNPStats, SNPAnalyzer, and Helixtree programs were used.

Results

The genotype and allele frequencies of ACE I/D polymorphism showed significant differences between the OPLL patients and the control subjects (genotype, p<0.001; allele, p=0.009). The frequencies of D/D genotype and D allele in the OPLL group were higher than those in the control group. In logistic regression analysis, ACE I/D polymorphism was associated with OPLL (dominant model; p=0.002; odd ratio, 2.20; 95% confidence interval, 1.33-3.65).

Conclusion

These results suggest that the deletion polymorphism of the ACE gene may be a risk factor for the development of OPLL in the Korean population.

Citations

Citations to this article as recorded by

Evaluation of Genetic and Nongenetic Risk Factors for Degenerative Cervical Myelopathy
Maksim A. Shlykov, Erica M. Giles, Michael P. Kelly, Shiow J. Lin, Vy T. Pham, Nancy L. Saccone, Elizabeth L. Yanik
Spine.2023; 48(16): 1117. CrossRef
Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments
Hajime Kato, Demetrios T. Braddock, Nobuaki Ito
Current Osteoporosis Reports.2023; 21(5): 552. CrossRef
Evidence for a genetic contribution to the ossification of spinal ligaments in Ossification of Posterior Longitudinal Ligament and Diffuse idiopathic skeletal hyperostosis: A narrative review
Ana Rita Couto, Bruna Parreira, Deborah M. Power, Luís Pinheiro, João Madruga Dias, Irina Novofastovski, Iris Eshed, Piercarlo Sarzi-Puttini, Nicola Pappone, Fabiola Atzeni, Jorrit-Jan Verlaan, Jonneke Kuperus, Amir Bieber, Pasquale Ambrosino, David Kiefe
Frontiers in Genetics.2022;[Epub] CrossRef
Genetics of Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis of Candidate Gene Studies
Daniel H. Pope, Benjamin M. Davies, Oliver D. Mowforth, A. Ramsay Bowden, Mark R. N. Kotter
Journal of Clinical Medicine.2020; 9(1): 282. CrossRef
Quantification of Risk Factors for Cervical Ossification of the Posterior Longitudinal Ligament in Korean Populations
Jaeyong Shin, Ja Young Choi, Yong Wook Kim, Jee Suk Chang, Seo Yeon Yoon
Spine.2019; 44(16): E957. CrossRef
Genetic polymorphisms in bone morphogenetic protein receptor type IA gene predisposes individuals to ossification of the posterior longitudinal ligament of the cervical spine via the smad signaling pathway
Hao Wang, Weitao Jin, Haibin Li
BMC Musculoskeletal Disorders.2018;[Epub] CrossRef
Cohort study of cervical ossification of posterior longitudinal ligament in a Korean populations: Demographics of prevalence, surgical treatment, and disability
Jaeyong Shin, Yong Wook Kim, Sang Gyu Lee, Eun-Cheol Park, Seo Yeon Yoon
Clinical Neurology and Neurosurgery.2018; 166: 4. CrossRef
The Pathogenesis of Ossification of the Posterior Longitudinal Ligament
Liang Yan, Rui Gao, Yang Liu, Baorong He, Shemin Lv, Dingjun Hao
Aging and disease.2017; 8(5): 570. CrossRef

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Prevalence and Association Factors of Posterior Longitudinal Ligament in Patients with Spondyloarthropathies.: Kim, Min Su , Kwon, Jong Won , Bae, Su Ho , Park, Yun Hee , Choi, Kyung Phil , Sung, Duk Hyun; J Korean Acad Rehabil Med 2009;33(5):557-563.

Abstract
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Objective
To investigate prevalence of ossification of posterior longitudinal ligament (OPLL) in Korean patients with Spondyloarthropathies (SpA), and the associations between OPLL and clinical, radiologic findings of SpA. Method: A cross-sectional radiological review was performed in patients diagnosed with SpA from 2000 to 2007. Each of two physiatrists and musculoskeletal radiologists screened the cervical (lateral) and pelvis (anterior-posterior) radiographs of these patients separately, then confirmed presence of OPLL. Bath ankylosing spondylitis radiology index (BASRI) of the cervical spine and grade of sacroiliitis were also measured. A review of the medical records and laboratory findings was conducted to investigate the association between the clinical, laboratory findings and the OPLL. Results: Among 172 patients with SpA, OPLL was found in 16 patients (9.3%; 95% CI 5.0, 13.6). There were significant associations between OPLL and old age (p=0.043), symptoms and signs of myeloradiculopathy (p=0.030), and diabetes mellitus (DM) (p=0.022). Conclusion: The prevalence of OPLL in Korean patients with SpA is 9.3%. OPLL in patients with SpA is associated with old age, symptoms and signs of myeloradiculopathy, and diabetes. However, no factors specific characteristics of SpA were associated with OPLL. (J Korean Acad Rehab Med 2009; 33: 557-563)

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Central Cord Syndrome Developed in Patients with Ossification of the Posterior Longitudinal Ligament: Clinical Features and Functional Outcomes.: Jung, Se Hee , Bang, Moon Suk , Lee, Kun Jai , Kim, Don Kyu , Han, Tai Ryoon; J Korean Acad Rehabil Med 2005;29(6):591-597.

Abstract
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Objective
Ossification of the posterior longitudinal ligament (OPLL) is a degenerative disorder of the spine which is related to cervical compressive myelopathy. We studied patients with central cord syndrome (CCS) to explore the implication of OPLL on clinical features and functional outcomes of CCS. Method: A retrospective study was conducted on 26 patients with CCS between 1998 and 2003. Demographic characteristics, mechanisms of injury, neurological impairments, main functional outcomes, and complications were identified. Clinical features and outcomes were compared between OPLL and non-OPLL group. Results: Twenty patients with CCS had OPLL (12/17 with traumatic and 8/9 with non-traumatic CCS). The initial ASIAObjective: Ossification of the posterior longitudinal ligament (OPLL) is a degenerative disorder of the spine which is related to cervical compressive myelopathy. We studied patients with central cord syndrome (CCS) to explore the implication of OPLL on clinical features and functional outcomes of CCS. Method: A retrospective study was conducted on 26 patients with CCS between 1998 and 2003. Demographic characteristics, mechanisms of injury, neurological impairments, main functional outcomes, and complications were identified. Clinical features and outcomes were compared between OPLL and non-OPLL group. Results: Twenty patients with CCS had OPLL (12/17 with traumatic and 8/9 with non-traumatic CCS). The initial ASIAmotor score of OPLL and non-OPLL patients was 67.8 and 65.3 and, at discharge, 82.8 and 78.5. There were no significant differences in gait, bladder management, length of stay, discharge disposition, and major complications between OPLL and non-OPLL group. Among OPLL patients, non- traumatic CCS patients showed higher ASIA motor score at discharge and had a tendency of better functional outcome than traumatic CCS patients. Conclusion: OPLL was commonly observed in CCS patients. Mechanism of injury rather than the presence of OPLL was a significant determinant of clinical features or functional outcomes of CCS. (J Korean Acad Rehab Med 2005; 29: 591-597)