Annals of Rehabilitation Medicine

Therapeutic Effect according to Estrogen Dosage on Combined Therapy with Estrogen and Alendronate in Postmenopausal Osteoporosis.: Kim, Ghi Chan , Jeong, Ho Joong , Ha, Ho Sung , Lee, Sang Jin; J Korean Acad Rehabil Med 2006;30(3):247-253.

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Objective
To compare the difference of bone mineral density (BMD), biochemical markers, and lipid profiles according to dosage of estrogen on combined therapy with estrogen and alendronate in postmenopausal osteoporosis. Method: We studied 81 women with postmenopausal osteoporosis (T-score＜2.5) from March 2002 to February 2005. Subjects were divided in two groups; Group I (n=36), treated with low dose hormone therapy (HT) (0.3 mg estrogen/1.25 mg MPA (Medroxyprogesterone acetate)) and alendronate, and Group II (n=45), treated with standard dose HT (0.625 mg estrogen/2.5 mg MPA) and alendronate. BMD at the L-spine and femur, osteocalcin, deoxypyridinoline, and lipid profiles were measured at baseline and 1 year after treatment.Results: BMD at the L-spine increased significantly in two groups and BMD at the femur increased but showed no statistical differences. Deoxypyridinoline and osteocalcin decreased significantly in two group. Total cholesterol and LDL (low density lipoprotein) cholesterol decreased significantly in two groups, no significant difference was observed between two groups in BMD, osteocalcin, deoxypyridinoline, and lipid profiles. Conclusion: We concluded that combined therapy with low dose estrogen and alendronate in postmenopausal osteoporosis showed similar therapeutic effect provied by combined therapy of standard dose estrogen and alendronate. (J Korean Acad Rehab Med 2006; 30: 247-253)

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Evaluation of Cardiopulmonary Function and Serum Lipid Profile in Spinal Cord Injured Patients.: Kim, Kweon Young , Shin, Soo Beom; J Korean Acad Rehabil Med 2006;30(3):236-240.

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Objective
To help cardiopulmonary rehabilitation and prevention of cardiovascular disease in spinal cord injured patients. Method: Twenty spinal cord injured patients were divided into 3 groups according to level of injury - cervical, thoracic and lumbar level groups. Exercise stress test was initiated at a velocity of 1.5 mph for 1 minute and was increased 0.5 mph for each subsequent minute. To evaluate blood lipid profiles, we measured total cholesterol, HDL (high density lipoprotein)-cholesterol, LDL (low density lipoprotein)-cholesterol and triglyceride levels in the fasting state. Results: Oxygen consumption, oxygen consumption ratio ofmaximal oxygen consumption and minute ventilation were significantly higher in the thoracic and lumbar cord level groups compared to the cervical cord level group (p＜0.05). There was a significant difference between all 3 groups in respect to total duration of exercise (p＜0.05). The HDL- cholesterol level showed significant correlation with total exercise time (p＜0.05). Conclusion: Cardiopulmonary evaluation by specialized wheel chair system in spinal cord injured patients may be more safe and accurate method compared to the previous examination. (J Korean Acad Rehab Med 2006; 30: 236-240)

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The Changes of Bone Mineral Density, Biochemical Bone Markers, and Lipid Profiles according to Duration of Menopause and HRT.: Kim, Ghi Chan , Jeong, Ho Joong , Roh, Kyung Hwan , Chung, Heung Chae , Kim, Heung Yeol , Lee, Hoan Nyoung; J Korean Acad Rehabil Med 2001;25(3):491-497.

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Objective: To investigate the changes of bone mineral density (BMD), biochemical bone markers, and lipid profiles according to the duration of menopause in postmenopausal osteoporosis patient receiving continuous hormonal replacement therapy (c-HRT).

Method: Sixty seven patients with postmenopausal osteoporosis who have been under c-HRT for more than two years were used as subjects and divided into two groups according to the time past menopause: group I (0∼10 years), group II (over 10 years). The changes of BMD, biochemical bone markers, lipid profiles on one year and two years of c-HRT were comparatively analyzed in each group.

Results: 1) BMD of lumbar vertebra was increased and biochemical bone markers were decreased after c-HRT in both groups, but BMD of femur from both groups showed no statistical significant changes. 2) The changes in lumbar vertebra, deoxypyridinoline and osteocalcin were significantly higher after first one year than next one year of c-HRT in both groups, with no statistical differences between two groups. 3) Total cholesterol and LDL-cholesterol were decreased, but HDL-cholesterol and triglyceride showed no significant changes after c-HRT in both groups.

Conclusion: The effects of c-HRT on BMD, biochemical bone markers, lipid profiles were not influenced by postmenopausal period. And the effects of c-HRT during first one year were more prominent than those of c-HRT during next one year.

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The Effect of Aerobic Exercise on the Cardiovascular System in the Early Stoke Patients.: Kim, Tae Sun , Cho, Kyoung Ja , Kim, Sang Hyun , Kim, Dong A , Yoo, Tae Weon , Ryu, Joong Sun; J Korean Acad Rehabil Med 1999;23(5):1020-1027.

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Objective: To evaluate the effect of aerobic exercise training on the cardiovascular system in the early stroke patients by bicycle ergometer exercise test.

Method: 16 stroke patients without cardiac disease were randomly assigned to exercise training group (8 patients) and control group (8 patients). The time interval between the onset of stroke and exercise training was within 90 days. Exercise tests by bicycle ergometer using Astrand-Ryhming protocol were performed twice before and after training. Exercise training was consisted with the intensity of 60∼70% of maximal heart rate, 30 minutes per day, 3 times per week for 6 weeks using bicycle ergometer. Modified Barthel Index (MBI) score and blood lipid profile were recorded before and during training. Blood pressure and heart rate were checked before and during exercise test.

Results: In a training group, maximal systolic blood pressure and rate pressure product were decreased immediately after exercise test after 6-weeks exercise training (p＜0.05). The MBI score and lipid profile were not changed after training.

Conclusion: Early exercise training in the stroke patients for 6 weeks have beneficial effects on the cardiovascular system.