Annals of Rehabilitation Medicine

"Joint contracture"

Case Report

Rehabilitation in Children With Sclerodermoid Chronic Graft-Versus-Host Disease: Case Series: Minji Jung, In Young Sung, Eun Jae Ko; Ann Rehabil Med 2019;43(3):347-351. Published online June 28, 2019; DOI: https://doi.org/10.5535/arm.2019.43.3.347

Abstract
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Joint contracture in chronic graft-versus-host disease (cGVHD) is refractory to treatment, and tends to deteriorate gradually over time. There is scant clinical research focusing on timing and intensity of rehabilitation on joint contractures in children with sclerodermoid cGVHD after hematopoietic stem cell transplantation. We retrospectively reviewed rehabilitative therapeutic effects in 6 children with sclerodermoid cGVHD, whose clinical records documented their condition, before and after rehabilitation therapies. Three children who started treatment within a mean of 2 months after the onset of joint symptoms, and who underwent home-based exercise twice daily for 30 minutes showed more prominent improvement in range of motion compared with the other 3 children, who started rehabilitation therapy later than 6 months after onset of joint symptoms, without regular home-based exercise.

Citations

Citations to this article as recorded by

Chronic graft-versus-host disease. Part II: Disease activity grading and therapeutic management
Emily Baumrin, Alison W. Loren, Sandy J. Falk, Jacqueline W. Mays, Edward W. Cowen
Journal of the American Academy of Dermatology.2024; 90(1): 19. CrossRef
Cutaneous Chronic Graft-Versus-Host Disease: Clinical Manifestations, Diagnosis, Management, and Supportive Care
Connie R. Shi, Alana L. Ferreira, Manjit Kaur, David Xiang, Jean Caputo, Hannah K. Choe, Nada Hamad, Edward W. Cowen, Benjamin H. Kaffenberger, Emily Baumrin
Transplantation and Cellular Therapy.2024; 30(9): S513. CrossRef
Graft versus host disease-related eosinophilic fasciitis: cohort description and literature review
Cristina Hidalgo Calleja, Daniel Martín Hidalgo, Concepción Román Curto, Lourdes Vázquez López, Estefanía Pérez López, Mónica Cabrero Calvo, Ana África Martín López, María Dolores Caballero Barrigón, Lucía Lopez-Corral
Advances in Rheumatology.2022;[Epub] CrossRef
Rehabilitation Interventions in the Multidisciplinary Management of Patients With Sclerotic Graft-Versus-Host Disease of the Skin and Fascia
Paula Molés-Poveda, Leora E. Comis, Galen O. Joe, Sandra A. Mitchell, Dominique C. Pichard, Rachel K. Rosenstein, Beth Solomon, Steven Z. Pavletic, Edward W. Cowen
Archives of Physical Medicine and Rehabilitation.2021; 102(4): 776. CrossRef

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Original Article

Effect of Pregnancy on Knee Joint Contracture in the Rat.: Kim, Joon Sung , Kang, Sae Yun; J Korean Acad Rehabil Med 1999;23(6):1095-1103.

Abstract
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Objective: To study the effect of pregnancy on knee joint contracture in the rat, because the laxity of peripheral joint increases during pregnacy.

Method: We evaluated the difference of contracture between the pregnant and non-pregnant female rats after 3 week of knee immobilization using a wire. The femorotibial angle at immobilization status was 30^o. After immobilization, the femorotibial angle were measured using X-ray after removal of wire at 50 g and 100 g weighted state on the tibia. To study the change of fibroblast in immobilized knee joint ligament, immunohistochemical staining for actin was performed using α-smooth muscle actin antibody (DAKO, Denmark).

Results: The femorotibial angles were 116.7⁑9.2^o and 97.3⁑18.0^o after wire removal, in the immobilized pregnant and nonpregnant rats respectively. The femorotibial angles at 50 g and 100 g weighted state were 136.8⁑7.2^o and 144.7⁑3.8^o, respectively in the immobilized pregnant rats and 129.4⁑12.7^o and 136.3⁑8.9^o in the immobilized non-pregnant rats. The angles of pregnant group were significantly larger than those of non-pregnant group (p＜0.05). In immobilized pregnant and non-pregnant rats, the α-smooth muscle actin was moderately expressed in fibroblast of anterior and posterior cruciate ligaments of the knee by immunohistochemistry, while there was no expression of α-smooth muscle actin in fibroblast of the ligaments in the non-immobilized knee.

Conclusion: Joint contracture develops to a lesser degree in pregnant rats than in non-pregnant rats and α-smooth muscle actin is expressed in fibroblast of contractured knee ligaments.