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"Epidural injections"

Original Articles

Ultrasonography Evaluation of Vulnerable Vessels Around Cervical Nerve Roots During Selective Cervical Nerve Root Block
Hoon Hoon Lee, Donghwi Park, Yoongul Oh, Ju Seok Ryu
Ann Rehabil Med 2017;41(1):66-71.   Published online February 28, 2017
DOI: https://doi.org/10.5535/arm.2017.41.1.66
Objective

To evaluate the prevalence of vulnerable blood vessels around cervical nerve roots before cervical nerve root block in the clinical setting.

Methods

This retrospective study included 74 patients with cervical radiculopathy who received an ultrasonography-guided nerve block at an outpatient clinic from July 2012 to July 2014. Before actual injection of the steroid was performed, we evaluated the vulnerable blood vessels around each C5, C6, and C7 nerve root of each patient's painful side, with Doppler ultrasound.

Results

Out of 74 cases, the C5 level had 2 blood vessels (2.7%), the C6 level had 4 blood vessels (5.45%), and the C7 level had 6 blood vessels (8.11%) close to each targeted nerve root. Moreover, the C5 level had 2 blood vessels (2.7%), the C6 level 5 blood vessels (6.75%), and the C7 level had 4 blood vessels (5.45%) at the site of an imaginary needle's projected pathway to the targeted nerve root, as revealed by axial transverse ultrasound imaging with color Doppler imaging. In total, the C5 level had 4 blood vessels (5.45%), the C6 level 9 blood vessels (12.16%), and the C7 level 10 had blood vessels (13.51%) either at the targeted nerve root or at the site of the imaginary needle's projected pathway to the targeted nerve root. There was an unneglectable prevalence of vulnerable blood vessels either at the targeted nerve root or at the site of the needle' projected pathway to the nerve root. Also, it shows a higher prevalence of vulnerable blood vessels either at the targeted nerve root or at the site of an imaginary needle's projected pathway to the nerve root as the spinal nerve root level gets lower.

Conclusion

To prevent unexpected critical complications involving vulnerable blood vessel injury during cervical nerve root block, it is recommended to routinely evaluate for the presence of vulnerable blood vessels around each cervical nerve root using Doppler ultrasound imaging before the cervical nerve root block, especially for the lower cervical nerve root level.

Citations

Citations to this article as recorded by  
  • Ultrasound-Guided Selective Cervical Root Block in Spondylotic Radiculopathy: Advantages and Safety
    Dong Gyu Lee
    Clinical Pain.2023; 22(2): 61.     CrossRef
  • A prospective randomized comparison of the efficacy of standard antiviral therapy versus ultrasound-guided thoracic paravertebral block for acute herpes zoster
    Yingchao Ma, Bingsi Li, Lei Sun, Xin He, Shuang Wu, Fan Shi, Li Niu
    Annals of Medicine.2022; 54(1): 369.     CrossRef
  • Diagnosis and Treatment of Cervical Spondylotic Radiculopathy Using Selective Nerve Root Block (SNRB): Where are We Now?
    Dongfang Yang, Lichen Xu, Yutong Hu, Weibing Xu
    Pain and Therapy.2022; 11(2): 341.     CrossRef
  • Remnant Tumor Margin as Predictive Factor for Its Growth After Incomplete Resection of Cervical Dumbbell-Shaped Schwannomas
    Kazuya Kitamura, Narihito Nagoshi, Osahiko Tsuji, Satoshi Suzuki, Satoshi Nori, Eijiro Okada, Mitsuru Yagi, Morio Matsumoto, Masaya Nakamura, Kota Watanabe
    Neurospine.2022; 19(1): 32.     CrossRef
  • An open-label non-inferiority randomized trail comparing the effectiveness and safety of ultrasound-guided selective cervical nerve root block and fluoroscopy-guided cervical transforaminal epidural block for cervical radiculopathy
    Xiaohong Cui, Di Zhang, Yongming Zhao, Yongsheng Song, Liangliang He, Jian Zhang
    Annals of Medicine.2022; 54(1): 2669.     CrossRef
  • Ultrasound-guided cervical selective nerve root injections: a narrative review of literature
    Reza Ehsanian, Byron J Schneider, David J Kennedy, Eugene Koshkin
    Regional Anesthesia & Pain Medicine.2021; 46(5): 416.     CrossRef
  • Procedimentos minimamente invasivos na coluna vertebral
    Hazem Adel Ashmawi, André Marques Mansano
    Revista Paulista de Reumatologia.2021; (2021 abr-j): 61.     CrossRef
  • Vascular Evaluation around the Cervical Nerve Roots during Ultrasound-Guided Cervical Nerve Root Block
    Shizumasa Murata, Hiroshi Iwasaki, Yuta Natsumi, Hiroshi Minagawa, Hiroshi Yamada
    Spine Surgery and Related Research.2020; 4(1): 18.     CrossRef
  • Ultrasound‐Guided Cervical Nerve Root Block for the Treatment of Acute Cervical Herpes Zoster: A Randomized Controlled Clinical Study
    Shuyue Zheng, Xiuhua Li, Xiaohui Yang, Liangliang He, Yanyan Xue, Zhanmin Yang
    Pain Practice.2019; 19(5): 500.     CrossRef
  • Cervical Ultrasound Utilization in Selective Cervical Nerve Root Injection for the Treatment of Cervical Radicular Pain: a Review
    Reza Ehsanian, David J. Kennedy, Byron Schneider
    Current Physical Medicine and Rehabilitation Reports.2019; 7(4): 386.     CrossRef
  • 6,927 View
  • 125 Download
  • 8 Web of Science
  • 10 Crossref
The Prognostic Value of Enhanced-MRI and Fluoroscopic Factors for Predicting the Effects of Transforaminal Steroid Injections on Lumbosacral Radiating Pain
Yun Suk Jung, Jee Hyun Suh, Ha Young Kim, Kyunghoon Min, Yoongul Oh, Donghwi Park, Ju Seok Ryu
Ann Rehabil Med 2016;40(6):1071-1081.   Published online December 30, 2016
DOI: https://doi.org/10.5535/arm.2016.40.6.1071
Objective

To investigate the predictive value of enhanced-magnetic resonance imaging (MRI) and fluoroscopic factors regarding the effects of transforaminal epidural steroid injections (TFESIs) in low back pain (LBP) patients with lumbosacral radiating pain.

Methods

A total of 51 patients who had LBP with radiating pain were recruited between January 2011 and December 2012. The patient data were classified into the two groups ‘favorable group’ and ‘non-favorable group’ after 2 weeks of follow-up results. The favorable group was defined as those with a 50%, or more, reduction of pain severity according to the visual analogue scale (VAS) for back or leg pain. The clinical and radiological data were collected for univariate and multivariate analyses to determine the predictors of the effectiveness of TFESIs between the two groups.

Results

According to the back or the leg favorable-VAS group, the univariate analysis revealed that the corticosteroid approach for the enhanced nerve root, the proportion of the proximal flow, and the contrast dispersion of epidurography are respectively statistically significant relative to the other factors. Lastly, the multiple logistic regression analysis showed a significant association between the corticosteroid approach and the enhanced nerve root in the favorable VAS group.

Conclusion

Among the variables, MRI showed that the corticosteroid approach for the enhanced target root is the most important prognostic factor in the predicting of the clinical parameters of the favorable TFESIs group.

Citations

Citations to this article as recorded by  
  • The role of facet joint degeneration in the treatment success of transforaminal epidural steroid injection: a retrospective clinical study
    Merve Sekizkardes Tutuncu, Savas Sencan, Canan Bilekyigit Kurt, Serdar Kokar, Osman Hakan Gunduz
    Skeletal Radiology.2025;[Epub]     CrossRef
  • Predictors of successful treatment after transforaminal epidural steroid injections in patients with lumbar disc herniation
    Mustafa Akif Sariyildiz, Ibrahim Batmaz, Salih Hattapoğlu
    Journal of Back and Musculoskeletal Rehabilitation.2024; 37(2): 327.     CrossRef
  • Acute back pain – Role of injection techniques and surgery: WFNS spine committee recommendations
    Nikolay Peev, Corinna Zygourakis, Christoph Sippl, G. Grasso, Joachim Oertel, Salman Sharif
    World Neurosurgery: X.2024; 22: 100315.     CrossRef
  • Clinical Effectiveness of Single Lumbar Periradicular Infiltration in Patients with Sciatica
    Dimitar Veljanovski, Sandra Dejanova Panev, Masha Kostova, Daniela Ristikj-Stomnaroska, Tatjana Deleva Stoshevska, Petar Janevski, Smiljana Bundovska Kocev, Biljana Prgova
    PRILOZI.2023; 44(2): 149.     CrossRef
  • CT-guided transforaminal epidural steroid injection for discogenic lumbar radiculopathy: influence of contrast dispersion and radiologist’s experience on clinical outcome
    Christoph Germann, Dimitri N. Graf, Benjamin Fritz, Reto Sutter
    Skeletal Radiology.2022; 51(4): 783.     CrossRef
  • Predictive value of immediate pain relief after lumbar transforaminal epidural injection with local anesthetics and steroids for single level radiculopathy
    Christoph Germann, Tobias Götschi, Reto Sutter
    Skeletal Radiology.2022; 51(10): 1975.     CrossRef
  • Association of Protein and Genetic Biomarkers With Response to Lumbar Epidural Steroid Injections in Subjects With Axial Low Back Pain
    Stephen Schaaf, Wan Huang, Subashan Perera, Yvette Conley, Inna Belfer, Prakash Jayabalan, Katie Tremont, Paulo Coelho, Sara Ernst, Megan Cortazzo, Debra Weiner, Nam Vo, James Kang, Gwendolyn Sowa
    American Journal of Physical Medicine & Rehabilitation.2021; 100(1): 48.     CrossRef
  • Predictive Factors for the Short-Term Efficacy of Epidural Injections in Lumbar Disc Herniation Treatment
    Jong Seok Baik, Yeong Tae Kim, Dae Jin Nam, Tae Kyun Kim
    Journal of Korean Society of Spine Surgery.2020; 27(4): 138.     CrossRef
  • Cross-sectional CT Assessment of the Extent of Injectate Spread at CT Fluoroscopy–guided Cervical Epidural Interlaminar Steroid Injections
    Timothy J. Amrhein, Erol Bozdogan, Sunit Vekaria, Prasad Patel, Reginald Lerebours, Sheng Luo, Peter G. Kranz
    Radiology.2019; 292(3): 723.     CrossRef
  • 5,797 View
  • 57 Download
  • 10 Web of Science
  • 9 Crossref
The Effect and Safety of Steroid Injection in Lumbar Spinal Stenosis: With or Without Local Anesthetics
Sung Hyuk Song, Gi Hyeong Ryu, Jin Woo Park, Ho Jun Lee, Ki Yeun Nam, Hyojun Kim, Seung Yeon Kim, Bum Sun Kwon
Ann Rehabil Med 2016;40(1):14-20.   Published online February 26, 2016
DOI: https://doi.org/10.5535/arm.2016.40.1.14
Objective

To compare the long-term effect and safety of an epidural steroid injection in spinal stenosis patients, with or without local anesthetics.

Methods

Twenty-nine patients diagnosed with spinal stenosis were included and randomly divided into two groups. Translaminar epidural and selective nerve root spinal injection procedures were performed using steroids mixed with local anesthetics or normal saline. The effects of spinal injection procedures were measured with visual analogue scale (VAS) and functional rate index (FRI). These measurements were performed before injection, at 1 month after injection and at 3 months after injection. The occurrence of side effects was investigated each time.

Results

The VAS and FRI scores were significantly reduced in both the local anesthetics group and normal saline group at 1 and 3 months after the injection. However, there was no significant difference in VAS and FRI score reduction between the two groups each time. Side effects are not noted in both groups.

Conclusion

The spinal injection procedures using steroids mixed either with local anesthetics or normal saline have an effect in reducing pain and improving functional activities. However, there was no significant difference between the two groups in relation to side effects and the long-term effects of pain and function.

Citations

Citations to this article as recorded by  
  • Real-Time MR-Guided Lumbosacral Periradicular Injection Therapy Using a 0.55 T MRI System: A Phantom Study
    Saher Saeed, Jan Boriesosdick, Arwed Michael, Nina Pauline Haag, Julian Schreck, Denise Schoenbeck, Matthias Michael Woeltjen, Julius Henning Niehoff, Christoph Moenninghoff, Jan Borggrefe, Jan Robert Kroeger
    Diagnostics.2025; 15(11): 1413.     CrossRef
  • Factfinders for patient safety: Epidural steroid injection in patients with lumbar spinal stenosis
    George Christolias, Aditya Raghunandan, Byron J. Schneider, Kunj Amin, David Hao, Jaymin Patel
    Interventional Pain Medicine.2024; 3(4): 100444.     CrossRef
  • A comparison between effectiveness of gluteal trigger point and epidural steroid injection in lumbosacral canal stenosis patients: a randomized clinical trial
    Sana Sadat Khoshnazar, Hamid Reza Farpour, Reza Shahriarirad
    British Journal of Neurosurgery.2023; 37(5): 1117.     CrossRef
  • Differentiating Lumbar Spinal Etiology from Peripheral Plexopathies
    Marco Foreman, Krisna Maddy, Aashay Patel, Akshay Reddy, Meredith Costello, Brandon Lucke-Wold
    Biomedicines.2023; 11(3): 756.     CrossRef
  • Safety of Epidural Hyaluronic Acid Injections in Managing the Symptoms of Lumbar Foraminal Stenosis: A Prospective Preliminary Study
    Piotr Godek, Kuba Ptaszkowski
    Journal of Clinical Medicine.2023; 12(6): 2359.     CrossRef
  • Intralesional corticosteroid injections are less painful without local anesthetic: a double-blind, randomized controlled trial
    Danny Zakria, James R. Patrinely, Anna K. Dewan, Sharon E. Albers, Lee E. Wheless, Aleta N. Simmons, Brian C. Drolet
    Journal of Dermatological Treatment.2022; 33(4): 2034.     CrossRef
  • Assessing the impact of adding bupivacaine on immediate and delayed post-procedure pain scores in interlaminar epidural steroid injections
    Cody R. Quirk, Anthony Onofrio, James T. Patrie, Nicholas C. Nacey
    Skeletal Radiology.2022; 51(1): 161.     CrossRef
  • Non-operative treatment for lumbar spinal stenosis with neurogenic claudication: an updated systematic review
    Carlo Ammendolia, Corey Hofkirchner, Joshua Plener, André Bussières, Michael J Schneider, James J Young, Andrea D Furlan, Kent Stuber, Aksa Ahmed, Carol Cancelliere, Aleisha Adeboyejo, Joseph Ornelas
    BMJ Open.2022; 12(1): e057724.     CrossRef
  • Do steroid injections to the peripheral nerve increase perineural fibrosis? An animal experimental study
    Mustafa ÇELİKTAŞ, Semih Kivanc OLGUNER, Kivilcim ERDOGAN, Remzi ÇAYLAK, Kenan DAĞLIOĞLU
    Journal of Surgery and Medicine.2022; 6(2): 181.     CrossRef
  • Recent Domestic and International Trends on Non-Surgical Treatment of Lumbar Spinal Stenosis
    Mi-Hyun Kim, K.M.D., Eun-Sang Park, Hyeon-Ho Hwang, Yeo-Gyeong Lee, Geum-Ju Song, Mi-Ri Kwon, Jun-Hyuk Kang
    Journal of Korean Medicine Rehabilitation.2021; 31(3): 1.     CrossRef
  • Short-Term Efficacy of Epidural Injection of Triamcinolone Through Translaminar Approach for the Treatment of Lumbar Canal Stenosis
    Saeed Sabbaghan, Elham Mirzamohammadi, Maryam Ameri Mahabadi, Farshad Nikouei, Farhad Rahbarian, Susan Ahmadichaboki, Samira Eftekhari, Maryam Zamankhani, Amir Aghaie Aghdam
    Anesthesiology and Pain Medicine.2020;[Epub]     CrossRef
  • Interventional Approaches to Low Back Pain
    Ariana M. Nelson, Geeta Nagpal
    Clinical Spine Surgery: A Spine Publication.2018; 31(5): 188.     CrossRef
  • Lumbale Radikulopathie: Klinik steht vor Bildgebung
    Franz Xaver Glocker
    Deutsches Ärzteblatt Online.2018;[Epub]     CrossRef
  • 5,474 View
  • 50 Download
  • 8 Web of Science
  • 13 Crossref

Case Report

Cervical Meningomyelitis After Lumbar Epidural Steroid Injection
Yujin Lee, Joon-Sung Kim, Ji Yeon Kim
Ann Rehabil Med 2015;39(3):504-507.   Published online June 30, 2015
DOI: https://doi.org/10.5535/arm.2015.39.3.504

Epidural steroid injections (ESI) are a common treatment for back pain management. ESI-related complications have increased with the growing number of procedures. We report a case of cervical meningomyelitis followed by multiple lumbar ESI. A 60-year-old male with diabetes mellitus presented to our hospital with severe neck pain. He had a history of multiple lumbar injections from a local pain clinic. After admission, high fever and elevated inflammatory values were detected. L-spine magnetic resonance imaging (MRI) revealed hematoma in the S1 epidural space. Antibiotic treatment began under the diagnosis of a lumbar epidural abscess. Despite the treatment, he started to complain of weakness in both lower extremities. Three days later, the weakness progressed to both upper extremities. C-spine MRI revealed cervical leptomeningeal enhancement in the medulla oblongata and cervical spinal cord. Removal of the epidural abscess was performed, but there was no neurological improvement.

Citations

Citations to this article as recorded by  
  • Injektionstherapie bei Zervikal- und Lumbalsyndromen: Grundlagen, Indikationen und allgemeine Durchführung
    J. Grifka, J. Götz, A. Fenk-Mayer, A. Benditz
    Die Orthopädie.2023; 52(12): 1017.     CrossRef
  • Bacterial Meningitis Complicated by Myelitis Following Anterior Cervical Spinal Surgery
    Dong-Hun Ham, Byeong-Yeol Choi, Myung-Cheol Jung
    Journal of the Korean Orthopaedic Association.2021; 56(6): 519.     CrossRef
  • Anwendung Bildwandler-gestützter Injektionen bei Zervikal- und Lumbalsyndromen
    F. Faber, A. Benditz, D. Boluki, J. Grifka
    Zeitschrift für Rheumatologie.2020; 79(4): 367.     CrossRef
  • Infection Risk of Lumbar Epidural Injection in the Operating Theatre Prior to Lumbar Fusion Surgery


    Peng Li, Xiuwei Hou, Lifeng Gao, Xiaochen Zheng
    Journal of Pain Research.2020; Volume 13: 2181.     CrossRef
  • Anwendung unterschiedlicher Injektionstherapien bei Zervikal- und Lumbalsyndromen
    F. Faber, A. Benditz, D. Boluki, J. Grifka
    Der Schmerz.2018; 32(1): 65.     CrossRef
  • Injektionstherapie bei Zervikal- und Lumbalsyndromen
    J. Grifka, A. Benditz, D. Boluki
    Der Orthopäde.2017; 46(2): 195.     CrossRef
  • The impact of preoperative epidural injections on postoperative infection in lumbar fusion surgery
    Anuj Singla, Scott Yang, Brian C. Werner, Jourdan M. Cancienne, Ali Nourbakhsh, Adam L. Shimer, Hamid Hassanzadeh, Francis H. Shen
    Journal of Neurosurgery: Spine.2017; 26(5): 645.     CrossRef
  • Spine Injectables: What Is the Safest Cocktail?
    Peter J. MacMahon, Ambrose J. Huang, William E. Palmer
    American Journal of Roentgenology.2016; 207(3): 526.     CrossRef
  • 6,178 View
  • 64 Download
  • 8 Web of Science
  • 8 Crossref
Original Article
Use of Magnetic Resonance Imaging to Identify Outcome Predictors of Caudal Epidural Steroid Injections for Lower Lumbar Radicular Pain Caused by a Herniated Disc
Sung Oh Cha, Chul Hoon Jang, Jin Oh Hong, Joon Sang Park, Jung Hyun Park
Ann Rehabil Med 2014;38(6):791-798.   Published online December 24, 2014
DOI: https://doi.org/10.5535/arm.2014.38.6.791
Objective

We used lumbar magnetic resonance image (MRI) findings to determine possible outcome predictors of a caudal epidural steroid injection (CESI) for radicular pain caused by a herniated lumbar disc (HLD).

Methods

Ninety-one patients with radicular pain whose MRI indicated a HLD were enrolled between September 2010 and July 2013. The CESIs were performed using ultrasound (US). A responder was defined as having complete relief or at least a 50% reduction of pain as assessed by the visual analog scale (VAS) and functional status on the Roland Morris Disability Questionnaire (RMDQ); responder (VAS n=61, RMDQ n=51), and non-responder (VAS n=30, RMDQ n=40). MRI findings were analyzed and compared between the two groups with regard to HLD level, HLD type (protrusion or exclusion), HLD zone (central, subarticular, foraminal, and extraforaminal), HLD volume (mild, moderate, or severe), relationship between HLD and nerve root (no contact, contact, displaced, or compressed), disc height loss (none, less than half, or more than half ), and disc degeneration grade (homogeneous disc structure or inhomogeneous disc structure-clear nucleus and height of intervertebral disc).

Results

A centrally located herniated disc was more common in the responder group than that in the non-responder group. Treatment of centrally located herniated discs showed satisfactory results. (VAS p=0.025, RMDQ p=0.040). Other factors, such as HLD level, HLD type, HLD volume, relationship to nerve root, disc height loss, and disc degeneration grade, were not critical.

Conclusion

The HLD zone was significant for pain reduction after CESI. A centrally located herniated disc was a predictor of a good clinical outcome.

Citations

Citations to this article as recorded by  
  • The role of psychosocial factors in mediating the treatment response of epidural steroid injections for low back pain with or without lumbosacral radiculopathy: A scoping review
    Meredith Stensland, Donald McGeary, Caleigh Covell, Elizabeth Fitzgerald, Mahsa Mojallal, Selena Lugosi, Luke Lehman, Zachary McCormick, Paul Nabity, Rajakumar Anbazhagan
    PLOS ONE.2025; 20(1): e0316366.     CrossRef
  • Transforaminal Epidural Injection for Far Lateral Lumbar Disc Herniations: An Alternative to Surgery or Just a Delay?
    Luay Serifoglu, Mustafa U Etli
    Cureus.2024;[Epub]     CrossRef
  • Prognostic factors associated with outcome following an epidural steroid injection for disc-related sciatica: a systematic review and narrative synthesis
    Alan Nagington, Nadine E. Foster, Kym Snell, Kika Konstantinou, Siobhán Stynes
    European Spine Journal.2023; 32(3): 1029.     CrossRef
  • Effect of Transforaminal Epidural Corticosteroid Injections in Acute Sciatica A Randomized Controlled Trial
    Bastiaan C. Ter Meulen, Johanna M. van Dongen, Esther Maas, Marinus H. van de Vegt, Johan Haumann, Henry C. Weinstein, Raymond Ostelo
    The Clinical Journal of Pain.2023;[Epub]     CrossRef
  • Fluoroscopically guided caudal epidural steroid injections for axial low back pain associated with central disc protrusions: a prospective outcome study
    James J. Lee, Elizabeth T. Nguyen, Julian R. Harrison, Caitlin K. Gribbin, Nicole R. Hurwitz, Jennifer Cheng, Kwadwo Boachie-Adjei, Eric A. Bogner, Peter J. Moley, James F. Wyss, Gregory E. Lutz
    International Orthopaedics.2019; 43(8): 1883.     CrossRef
  • Factors for Predicting Favorable Outcome of Percutaneous Epidural Adhesiolysis for Lumbar Disc Herniation
    Sang Ho Moon, Jae Il Lee, Hyun Seok Cho, Jin Woo Shin, Won Uk Koh
    Pain Research and Management.2017; 2017: 1.     CrossRef
  • The Effectiveness of Transforaminal Versus Caudal Routes for Epidural Steroid Injections in Managing Lumbosacral Radicular Pain
    Jun Liu, Hengxing Zhou, Lu Lu, Xueying Li, Jun Jia, Zhongju Shi, Xue Yao, Qiuli Wu, Shiqing Feng
    Medicine.2016; 95(18): e3373.     CrossRef
  • 5,901 View
  • 53 Download
  • 8 Web of Science
  • 7 Crossref
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