Annals of Rehabilitation Medicine

Drug Induced Parkinsonism Caused by the Concurrent Use of Donepezil and Risperidone in a Patient With Traumatic Brain Injuries: Si Hyun Kang, Don-Kyu Kim; Ann Rehabil Med 2013;37(1):147-150. Published online February 28, 2013; DOI: https://doi.org/10.5535/arm.2013.37.1.147

Abstract
PDF

A 69-year-old male patient with previous history of traumatic brain injury 5 months ago was admitted to the Department of Neuropsychiatry because of aggressive behavior and delusional features. After starting on 2 mg of risperidone per day, his delusion, anxiety, and aggressive behavior gradually improved. Two weeks later, he was given 10 mg of donepezil per day for his mild cognitive impairment. After 6 weeks of admission in the Department of Neuropsychiatry, he showed parkinsonian features including difficulty in walking, decreased arm swing during walking, narrowed step width, scooped posture, bradykinesia, tremor, and sleep disorder. To rule out the primary Parkinsonism, dopamine transporter imaging technique [18F]fluoropropyl-carbomethoxy-iodopropyl-nor-β-tropane positron emission tomography-computed tomography (18F]FP(IT PET-CT)) was performed, and dopamine transporter activity was not decreased. We considered that his parkinsonian features were associated with the combination of risperidone and donepezil. Both drugs were stopped and symptoms rapidly disappeared in several days.

Citations

Citations to this article as recorded by

Movement disorders associated with acetylcholinesterase inhibitors in Alzheimer’s dementia: A systematic review
Jamir Pitton Rissardo, Ana Letícia Fornari Caprara
Brain Circulation.2025; 11(1): 9. CrossRef
Acetylcholinesterase inhibitors to enhance recovery from traumatic brain injury: a comprehensive review and case series
Samuel A Florentino, Mohammad H Bawany, Heather M Ma
Brain Injury.2022; 36(4): 441. CrossRef
Classics in Chemical Neuroscience: Donepezil
James T. Brewster, Simone Dell’Acqua, Danny Q. Thach, Jonathan L. Sessler
ACS Chemical Neuroscience.2019; 10(1): 155. CrossRef
Drug-Induced Parkinsonism Manifesting as Gait Freezing in a Patient With Traumatic Brain Injury: A Case Report
Ho Sang Yoo, Yong Wook Kim, Na Young Kim
Clinical Neuropharmacology.2019; 42(3): 94. CrossRef
The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress
Hugo Juárez Olguín, David Calderón Guzmán, Ernestina Hernández García, Gerardo Barragán Mejía, Anne-Laure Bulteau
Oxidative Medicine and Cellular Longevity.2016;[Epub] CrossRef
Catecholaminergic based therapies for functional recovery after TBI
Nicole D. Osier, C. Edward Dixon
Brain Research.2016; 1640: 15. CrossRef

6,738 View
33 Download
6 Crossref

The Efficacy of Donepezil on Cognitive Dysfunction in Subacute Post-stroke Patients.: Kim, Deog Young , Park, Chang il , Ohn, Suk Hoon , Yang, Eun Joo , Ahn, So Young , Na, Sang Il; J Korean Acad Rehabil Med 2006;30(2):111-115.

Abstract
PDF

Objective
To evaluate the efficacy of donepezil on cognitive dysfunction in subacute post-stroke patients. Method: Sixty subacute stroke subjects were enrolled and randomly assigned into an experimental or control group. There was no significant difference between the two groups in age, sex and post-onset duration. Donepezil 5 mg was administered daily for 6 weeks to patients in the experimental group. Mini-Mental Status Examination (MMSE), Wechsler Memory Test (WMT) and Colored Progressive Matrices (CPM) were performed before and 6 weeks after administration of the study drug in both groups. Results: There was no difference between the two groupsin the MMSE, WMT, CPM scores at baseline. Six weeks later, the total score, memory input, recall and judgement as measured by the MMSE and the score on the WMT were significantly more improved in the experimental group when compared to the control group (p＜0.05). However, there was no significant difference between the two groups on the CPM score. Conclusion: These results suggested that donepezil may be helpful for improving cognitive function, especially memory in post-stroke patients. (J Korean Acad Rehab Med 2006; 30: 111-115)

1,986 View
24 Download

Effect of Donepezil on Cognitive Function in Patients with Brain Injury.: Kim, Yun Hee , Shin, Seung Hun , Park, Sung Hee , Ko, Myoung Hwan; J Korean Acad Rehabil Med 2002;26(4):374-378.

Abstract
PDF

Objective: To evaluate the effect of donepezil on cognitive function in patients with brain injury who had cognitive impairment.

Method: Twenty one subjects with brain injury (18 males, 3 females) were enrolled and classified into two groups, experimentaland control group. There was no significant difference between two groups in age, postonset duration, and level of education. For the experimental group, one tablelet of Aricept^Ⱂ(5 mg of donepezil per tablet) was administered daily for 6 weeks. The baseline and follow up cognitive assessments were performed before and 6 weeks after. Mini- mental Status Examination (MMSE), Computerized Neuropsychologic Test (CNT), Judgement of Line Orientation (JLO), and visuospatial Wechsler memory test were used for the assessment of cognitive function.

Results: In baseline study, two groups showed no difference in their cognitive function. After 6 weeks, the experimental group showed significantly higher performance in forward digit span, verbal learning test, backward visual span, visual learning test, non-verbal Wechsler memory test, and judgement of line orientaion than control group (p＜0.05).

Conclusion: These results suggested that the administration of Aricept^Ⱂ was beneficial in improving the cognitive function, especially verbal and visual memory and visuospatial perception in patients with brain injury. (J Korean Acad Rehab Med 2002; 26: 374-378)