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"Constraint-induced movement therapy"

Original Articles
Can Short-Term Constraint-Induced Movement Therapy Combined With Visual Biofeedback Training Improve Hemiplegic Upper Limb Function of Subacute Stroke Patients?
Hyun Seok, Seung Yeol Lee, Jihoon Kim, Jungho Yeo, Hyungdong Kang
Ann Rehabil Med 2016;40(6):998-1009.   Published online December 30, 2016
DOI: https://doi.org/10.5535/arm.2016.40.6.998
Objective

To Investigate the synergic effects of short-term constraint-induced movement therapy (CIMT) and visual biofeedback training (VBT) in subacute stroke patients.

Methods

Thirty-two subacute stroke patients were enrolled and randomly assigned to one of three groups: short-term CIMT with VBT, VBT only, and control groups. We applied CIMT for an hour daily during VBT instead of the ordinary restraint time, referred to as 'short-term' CIMT. Short-term CIMT with VBT group received simultaneous VBT with CIMT, whereas the VBT the only group received VBT without CIMT for an hour a day for 2 weeks. The control group received conventional occupational therapy (OT) alone. Patients underwent the Purdue Pegboard Test, the JAMAR grip strength test, the Wolf Motor Function Test, the Fugl-Meyer Assessment (upper extremity), Motricity index and the Korean version of Modified Barthel Index test to evaluate motor functions of the hemiplegic upper limb at baseline, post-treatment, and 2 weeks after treatment.

Results

No significant differences were observed between short-term CIMT with VBT and VBT only groups. Both groups showed significantly higher scores compared to the control group in the WMFT and FMA tests. However, the short-term CIMT with VBT group showed significant improvement (p<0.05) compared with the control group in both grasp and pad pinch at post-treatment and 2 weeks after treatment while the VBT only group did not.

Conclusion

Short-term CIMT with VBT group did not show significant improvement of hemiplegic upper limb function of subacute stroke patients, compared to VBT only group. Larger sample sizes and different restraint times would be needed to clarify the effect.

Citations

Citations to this article as recorded by  
  • Visual biofeedback for shortening second stage of labor: randomized controlled trial
    E. Preuss, A. De Porto, I. Zisman, H. Bason, O. Ron‐Tal, J. Tovbin, E. Barzilay
    Ultrasound in Obstetrics & Gynecology.2024; 63(1): 9.     CrossRef
  • Global research hotspots and trends in constraint-induced movement therapy in rehabilitation over the past 30 years: a bibliometric and visualization study
    Jie Xu, Meng Chen, Xin Wang, Zijuan Cai, Yanjie Wang, Xiaobing Luo
    Frontiers in Neurology.2024;[Epub]     CrossRef
  • Recovery after ischemic stroke: Effects of FuekFone home-based program on upper limb and cognitive function
    Yaowalak Kumkwan, Ketsarin Utriyaprasit, Thitipong Tankumpuan, Zeng Lertmanorat, Boonyanit Mathayomchan
    International Journal of Nursing Sciences.2024; 11(4): 414.     CrossRef
  • Biofeedback interventions for short term upper limb function following stroke: A systematic review with meta-analysis
    Ana Clara Bonini-Rocha, Anderson Lúcio Souza de Andrade, Ruth dos Santos Pereira, André Marques de Moraes, Liana Barbaresco Gomide Matheus, Sérgio Teixeira da Fonseca, Alexandre Lima de Araújo Ribeiro, Wagner Rodrigues Martins
    Journal of Hand Therapy.2023; 36(3): 693.     CrossRef
  • Progress in the clinical application of constraint-induced therapy following stroke since 2014
    Yinxing Cui, Ningyi Ma, Xuncan Liu, Yawen Lian, Yinghua Li, Guoxing Xu, Jiaming Zhang, Zhenlan Li
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • The Mechanism and Clinical Application of Constraint-Induced Movement Therapy in Stroke Rehabilitation
    Dong Wang, Junlu Xiang, Ying He, Min Yuan, Li Dong, Zhenli Ye, Wei Mao
    Frontiers in Behavioral Neuroscience.2022;[Epub]     CrossRef
  • Intrapartum ultrasound for the management of the active pushing phase
    Yinon Gilboa, Sharon Perlman
    American Journal of Obstetrics & Gynecology MFM.2021; 3(6): 100422.     CrossRef
  • The clinical effect of Kinesio taping and modified constraint-induced movement therapy on upper extremity function and spasticity in patients with stroke: a randomized controlled pilot study
    Han-Chin HSIEH, Ruei-Dan LIAO, Tsung-Hsun YANG, Chau-Peng LEONG, Hui-Hsin TSO, Jia-Ying WU, Yu-Chi HUANG
    European Journal of Physical and Rehabilitation Medicine.2021;[Epub]     CrossRef
  • Imagética motora e terapia por contensão induzida modificada na disfunção do membro superior pós-AVE – Revisão Sistemática
    Thamiris Barbosa da Silva, Rodrigo Freitas, Luiz Carlos Soares de Oliveira
    Revista Científica Multidisciplinar Núcleo do Conhecimento.2021; : 133.     CrossRef
  • Effectiveness and Superiority of Rehabilitative Treatments in Enhancing Motor Recovery Within 6 Months Poststroke: A Systemic Review
    I-Hsien Lin, Han-Ting Tsai, Chien-Yung Wang, Chih-Yang Hsu, Tsan-Hon Liou, Yen-Nung Lin
    Archives of Physical Medicine and Rehabilitation.2019; 100(2): 366.     CrossRef
  • Is there a dose-dependent effect of modified constraint-induced movement therapy in patients with hemiplegia?
    Hyo Jeong Lee, Hyun Im Moon, Joo Sup Kim, Tae Im Yi
    NeuroRehabilitation.2019; 45(1): 57.     CrossRef
  • Rehabilitation methods for reducing shoulder subluxation in post-stroke hemiparesis: a systematic review
    Kamal Narayan Arya, Shanta Pandian, Vikas, Vinod Puri
    Topics in Stroke Rehabilitation.2018; 25(1): 68.     CrossRef
  • Visual biofeedback using transperineal ultrasound in second stage of labor
    Y. Gilboa, T. I. Frenkel, Y. Schlesinger, S. Rousseau, D. Hamiel, R. Achiron, S. Perlman
    Ultrasound in Obstetrics & Gynecology.2018; 52(1): 91.     CrossRef
  • 8,001 View
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  • 14 Web of Science
  • 13 Crossref
Effect of Constraint-Induced Movement Therapy and Mirror Therapy for Patients With Subacute Stroke
Jin A Yoon, Bon Il Koo, Myung Jun Shin, Yong Beom Shin, Hyun-Yoon Ko, Yong-Il Shin
Ann Rehabil Med 2014;38(4):458-466.   Published online August 28, 2014
DOI: https://doi.org/10.5535/arm.2014.38.4.458
Objective

To evaluate the effectiveness of constraint-induced movement therapy (CIMT) and combined mirror therapy for inpatient rehabilitation of the patients with subacute stroke.

Methods

Twenty-six patients with subacute stroke were enrolled and randomly divided into three groups: CIMT combined with mirror therapy group, CIMT only group, and control group. Two weeks of CIMT for 6 hours a day with or without mirror therapy for 30 minutes a day were performed under supervision. All groups received conventional occupational therapy for 40 minutes a day for the same period. The CIMT only group and control group also received additional self-exercise to substitute for mirror therapy. The box and block test, 9-hole Pegboard test, grip strength, Brunnstrom stage, Wolf motor function test, Fugl-Meyer assessment, and the Korean version of Modified Barthel Index were performed prior to and two weeks after the treatment.

Results

After two weeks of treatment, the CIMT groups with and without mirror therapy showed higher improvement (p<0.05) than the control group, in most of functional assessments for hemiplegic upper extremity. The CIMT combined with mirror therapy group showed higher improvement than CIMT only group in box and block test, 9-hole Pegboard test, and grip strength, which represent fine motor functions of the upper extremity.

Conclusion

The short-term CIMT combined with mirror therapy group showed more improvement compared to CIMT only group and control group, in the fine motor functions of hemiplegic upper extremity for the patients with subacute stroke.

Citations

Citations to this article as recorded by  
  • Could aerobic exercise applied before constraint-induced movement therapy change circulating molecular biomarkers in chronic post-stroke?
    Luisa Fernanda García-Salazar, Natalia Duarte Pereira, Erika Shirley Moreira Silva, Jean Alex Matos Ribeiro, Gabriela Nagai Ocamoto, Rafaella Mendes Zambetta, Simone Garcia de Oliveira, Aparecida Maria Catai, Alexandra Borstad, Thiago Luiz Russo
    Physiotherapy Theory and Practice.2025; 41(6): 1191.     CrossRef
  • Application of visual feedback and AR-enhanced wheelchair skill training
    Xiong-Wen Ke, Yong “Tai” Wang, Aiqiao Shi, Zhi Zheng, Dan Phillips, David Long, Shihui Chen, Bradford Berk
    Disability and Rehabilitation: Assistive Technology.2025; 20(4): 757.     CrossRef
  • Post-Stroke Rehabilitation: Neurophysiology Processes of Bilateral Movement Training and Interlimb Coupling—A Systematic Review
    Jan A. Kuipers, Norman Hoffman, Frederick R. Carrick, Monèm Jemni
    Journal of Clinical Medicine.2025; 14(11): 3757.     CrossRef
  • Atlas-based analysis of diffusion imaging may predict efficacy of forelimb movement therapy for motor recovery in post-stroke rats
    Xinxin Zhao, Jingjing Ruan, Bo Li, Jiahui Cheng, Jianrong Xu, Yulian Zhu, Ce Li, Yan Zhou
    NeuroImage.2025; 321: 121517.     CrossRef
  • Mapping the Comparative Effectiveness of Modified Constraint-Induced Movement Therapy, Hand-Arm Bimanual Intensive Training, and Mirror Therapy for Upper Extremity Rehabilitation in Children With Hemiplegic Cerebral Palsy: A Scoping Review
    Rahul Bisen, Suvarna Ganvir
    Cureus.2025;[Epub]     CrossRef
  • Global research hotspots and trends in constraint-induced movement therapy in rehabilitation over the past 30 years: a bibliometric and visualization study
    Jie Xu, Meng Chen, Xin Wang, Zijuan Cai, Yanjie Wang, Xiaobing Luo
    Frontiers in Neurology.2024;[Epub]     CrossRef
  • How does combining physical therapy with transcranial direct stimulation improve upper-limb motor functions in patients with stroke? A theory perspective
    Alaa. M. Albishi
    Annals of Medicine & Surgery.2024; 86(8): 4601.     CrossRef
  • The Effect of Constraint-Induced Movement Therapy on Arm Function and Activities of Daily Living in Post-stroke Patients: A Systematic Review and Meta-Analysis
    Hyoseon Choi, Hyun Jung Kim
    Brain & Neurorehabilitation.2024;[Epub]     CrossRef
  • Repetitive facilitative exercise under continuous electrical stimulation for recovery of pure motor isolated hand palsy after infarction of the “hand knob” area: A case report
    Takashi Hoei, Kazumi Kawahira, Megumi Shimodozono, Hidefumi Fukuda, Keizo Shigenobu, Tadashi Ogura, Shuji Matsumoto
    Physiotherapy Theory and Practice.2023; 39(7): 1545.     CrossRef
  • Effects of stochastic resonance stimulation on manual function in children with hemiplegic cerebral palsy: A pilot clinical trial
    Jessica Lynn, Allison Wolf, Travis Bridges, Zachary Pottanat, Suzanne Spivey, Olivier Rolin
    PM&R.2023; 15(3): 302.     CrossRef
  • Effect of different constraint-induced movement therapy protocols on recovery of stroke survivors with upper extremity dysfunction: a systematic review and network meta-analysis
    Qian Gao, Yasu Zhang, Junzi Long, Mengyang Pan, Jing Wang, Fangjie Yang
    International Journal of Rehabilitation Research.2023; 46(2): 133.     CrossRef
  • Progress in the clinical application of constraint-induced therapy following stroke since 2014
    Yinxing Cui, Ningyi Ma, Xuncan Liu, Yawen Lian, Yinghua Li, Guoxing Xu, Jiaming Zhang, Zhenlan Li
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • Comparaison de la thérapie miroir unimanuelle et bimanuelle pour l’amélioration motrice et fonctionnelle du membre supérieur après AVC : une revue systématique et méta-analyse
    Thomas Picot, Gaël Le Perf
    Kinésithérapie, la Revue.2022; 22(242): 11.     CrossRef
  • Integrating hand exoskeletons into goal-oriented clinic and home stroke and spinal cord injury rehabilitation
    Aaron Yurkewich, Sara Ortega, José Sanchez, Rosalie H Wang, Etienne Burdet
    Journal of Rehabilitation and Assistive Technologies Engineering.2022;[Epub]     CrossRef
  • Effects of constraint-induced movement therapy on activity and participation after a stroke: Systematic review and meta-analysis
    Joyce Araújo de Azevedo, Felipe Douglas Silva Barbosa, Valquiria Martins Seixas, Kelly Regina Dias da Silva Scipioni, Priscila Yukari Sewo Sampaio, Daniel Marinho Cezar da Cruz, Daniele Piscitelli, Kevin K. Chui, Aristela de Freitas Zanona
    Frontiers in Human Neuroscience.2022;[Epub]     CrossRef
  • Effect of Modified Constraint-Induced Movement Therapy on Upper Extremity Function for Stroke Patients with Right/Left Arm Paresis: Single-Blind Randomized Controlled Trial
    Cansın MEDİN CEYLAN, Ekin İlke ŞEN, Tugce KARAAGAC, Tuğba ŞAHBAZ, Ayse YALIMAN
    Ahi Evran Medical Journal.2022;[Epub]     CrossRef
  • Constraint-induced movement therapy enhances AMPA receptor-dependent synaptic plasticity in the ipsilateral hemisphere following ischemic stroke
    Jian Hu, Pei-Le Liu, Yan Hua, Bei-Yao Gao, Yu-Yuan Wang, Yu-Long Bai, Chan Chen
    Neural Regeneration Research.2021; 16(2): 319.     CrossRef
  • Effects of Mirror Therapy Combined With EMG-triggered Functional Electrical Stimulation to Improve on Upper Extremity Function in Patient with Chronic Stroke
    Joo Yeol Jung, Pong Sub Youn, Dong Hoon Kim
    Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin.2021; 31(02): 127.     CrossRef
  • Effectiveness of self-administered mirror therapy on upper extremity impairments and function of acute stroke patients: study protocol
    Venkadesan Rajendran, Deepa Jeevanantham, Céline Larivière, Ravinder-Jeet Singh, Lisa Zeman, Padma Papuri
    Trials.2021;[Epub]     CrossRef
  • Constrained-induced movement therapy promotes motor function recovery by enhancing the remodeling of ipsilesional corticospinal tract in rats after stroke
    Jian Hu, Ce Li, Yan Hua, Bei Zhang, Bei-Yao Gao, Pei-Le Liu, Li-Min Sun, Rong-Rong Lu, Yu-Yuan Wang, Yu-Long Bai
    Brain Research.2019; 1708: 27.     CrossRef
  • How to perform mirror therapy after stroke? Evidence from a meta-analysis
    Nadine Morkisch, Holm Thieme, Christian Dohle
    Restorative Neurology and Neuroscience.2019; 37(5): 421.     CrossRef
  • Effect of aerobic exercise prior to modified constraint-induced movement therapy outcomes in individuals with chronic hemiparesis: a study protocol for a randomized clinical trial
    Erika Shirley Moreira da Silva, Gabriela Lopes Santos, Aparecida Maria Catai, Alexandra Borstad, Natália Pereira Duarte Furtado, Isabela Arruda Verzola Aniceto, Thiago Luiz Russo
    BMC Neurology.2019;[Epub]     CrossRef
  • Rehabilitation Interventions for Upper Limb Function in the First Four Weeks Following Stroke: A Systematic Review and Meta-Analysis of the Evidence
    Kimberley A. Wattchow, Michelle N. McDonnell, Susan L. Hillier
    Archives of Physical Medicine and Rehabilitation.2018; 99(2): 367.     CrossRef
  • Effects of 8-week sensory electrical stimulation combined with motor training on EEG-EMG coherence and motor function in individuals with stroke
    Li-Ling Hope Pan, Wen-Wen Yang, Chung-Lan Kao, Mei-Wun Tsai, Shun-Hwa Wei, Felipe Fregni, Vincent Chiun-Fan Chen, Li-Wei Chou
    Scientific Reports.2018;[Epub]     CrossRef
  • Early versus late‐applied constraint‐induced movement therapy: A multisite, randomized controlled trial with a 12‐month follow‐up
    Roland Stock, Gyrd Thrane, Audny Anke, Ragna Gjone, Torunn Askim
    Physiotherapy Research International.2018;[Epub]     CrossRef
  • Mirror therapy for improving motor function after stroke
    Holm Thieme, Nadine Morkisch, Jan Mehrholz, Marcus Pohl, Johann Behrens, Bernhard Borgetto, Christian Dohle
    Cochrane Database of Systematic Reviews.2018;[Epub]     CrossRef
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    Davide G de Sousa, Lisa A Harvey, Simone Dorsch, Joanne V Glinsky
    Journal of Physiotherapy.2018; 64(4): 210.     CrossRef
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    Yumi Ju, In-Jin Yoon
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    Kasondra Hartman, Eric L. Altschuler
    Current Physical Medicine and Rehabilitation Reports.2016; 4(4): 237.     CrossRef
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    Suellen M. Andrade, Natanael A. Santos, Bernardino Fernández-Calvo, Paulo S. Boggio, Eliane A. Oliveira, José J. Ferreira, Amanda Sobreira, Felipe Morgan, Germana Medeiros, Gyovanna S. Cavalcanti, Ingrid D. Gadelha, Jader Duarte, Joercia Marrocos, Michele
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    Kil-Byung Lim, Hong-Jae Lee, Jeehyun Yoo, Hyun-Ju Yun, Hye-Jung Hwang
    Annals of Rehabilitation Medicine.2016; 40(4): 629.     CrossRef
  • Can Short-Term Constraint-Induced Movement Therapy Combined With Visual Biofeedback Training Improve Hemiplegic Upper Limb Function of Subacute Stroke Patients?
    Hyun Seok, Seung Yeol Lee, Jihoon Kim, Jungho Yeo, Hyungdong Kang
    Annals of Rehabilitation Medicine.2016; 40(6): 998.     CrossRef
  • Constraint-induced movement therapy as a rehabilitation intervention for upper extremity in stroke patients: systematic review and meta-analysis
    Mohammad Etoom, Mohannad Hawamdeh, Ziad Hawamdeh, Mohammad Alwardat, Laura Giordani, Serenella Bacciu, Claudia Scarpini, Calogero Foti
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    Cochrane Database of Systematic Reviews.2015;[Epub]     CrossRef
  • Immediate video feedback on ramp, wheelie, and curb wheelchair skill training for persons with spinal cord injury
    Yong Tai Wang, Weerawat Limroongreungrat, Li-Shan Chang, Xiang Ke, Liang-Ching Tsai, Yu-Ping Chen, James Lewis
    Journal of Rehabilitation Research and Development.2015; 52(4): 421.     CrossRef
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    Qing Tang, Guangming Li, Tao Liu, Anguo Wang, Shenggang Feng, Xiang Liao, Yu Jin, Zhiwei Guo, Bin He, Morgan A. McClure, Guoqiang Xing, Qiwen Mu
    Neuroscience & Biobehavioral Reviews.2015; 57: 392.     CrossRef
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    Luca Mirela Cristina, Daniela Matei, Bogdan Ignat, Cristian Dinu Popescu
    Acta Neurologica Belgica.2015; 115(4): 597.     CrossRef
  • 12,521 View
  • 305 Download
  • 36 Web of Science
  • 38 Crossref
Effects of the Constraint-Induced Movement Therapy on Cortical Reorganization in Patients with Hemiplegic Cerebral Palsy.
Lee, Zee Ihn , Byun, Seung Deuk , Chun, Kyung Ah
J Korean Acad Rehabil Med 2009;33(4):408-414.
Objective
To investigate the effects of modified constraint- induced movement therapy (CIMT) on motor function and cortical activation in children with hemiplegic cerebral palsy (CP). Method: Five children with hemiplegic cerebral palsy were studied with Jebsen hand function test and quality of upper extremity skills test (QUEST), dynamic electromyography (EMG), and single photon emission computed tomography (SPECT) at rest before and after the CIMT period. Children were treated with a 4-week protocol of modified CIMT, consisting of twice-weekly 2-hour sessions of structured activities and a home program for non-treatment days. Children wore orthoses on their less affected upper extremities for 6 hours per day, during which time they were engaged in play, functional activities and 2-hour protocol of motor tasks. Results: Improvements in upper-extremity function were found in Jebsen hand function test and QUEST. Increased muscle activities in elbow extensors were observed in dynamic EMG during affected hand grip. In right hemiplegic patients, regional cerebral perfusion increased in right Brodmann area (BA) 3 and lentiform nucleus. In left hemiplegic patients, regional cerebral perfusion increased in right BA 6, 9, 21, left BA 19 and left cerebellum, but decreased in left BA 11. Conclusion: Modified CIMT appears to change local cerebral perfusion in areas known to participate in movement planning and execution. These changes might be a sign of cortical activation after CIMT in the children with hemiplegic cerebral palsy. Results of this study suggest that modified CIMT may be an effective way of treating children with hemiplegic CP. (J Korean Acad Rehab Med 2009; 33: 408-414)
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The Effect of Modified Constraint-induced Movement Therapy for the Stroke Patients in Inpatient Setting.
Son, Mi Ok , Kim, Eun Soo , Park, Si Woon , Kim, Kyong Mi , Jang, Soon Ja , Oh, Jae Keun
J Korean Acad Rehabil Med 2007;31(1):56-62.
Objective
To evaluate the effectiveness of the modified constraint-induced movement therapy (CIMT) for inpatient rehabilitation of the stroke patients. Method: Twenty-four patients admitted by subacute or chronic stroke were enrolled and divided into two groups, experimental and control groups. The experimental group (n=13) received the CIMT five days a week for 2 weeks. Less affected arm was restrained for 14 hours a day, practicing purposeful activities with more affected arm for 6 hours a day in group setting. The control group (n=11) received conventional occupational therapy for the same period. The outcome was measured by Fugl-Meyer Motor Assessment (FMA), Brunnstrom stage, Jebsen hand function test, grip strength, Box and Block test, nine hole peg test, Functional Independence Measure (FIM), and Motor Activity Log (MAL). Results: The experimental group showed significantly higher improvements (p<0.05) in FMA, Brunnstorm stage, Jebsen hand function test, grip strength, Box and Block test, FIM, and MAL. Conclusion: Modified CIMT delivered in group setting is considered to be an effective treatment to improve functional use of the hemiparetic arm of stroke patients in inpatient setting. (J Korean Acad Rehab Med 2007; 31: 56-62)
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Effect of Constraint-Induced Movement Therapy in Chronic Hemiplegic Patients.
Kim, Deog Young , Park, Chang Il , Chang, Won Hyuk , Jang, Yong Won
J Korean Acad Rehabil Med 2003;27(6):813-818.
Objective: To evaluate the effectiveness of constraint-induced movement therapy (CIT) for chronic hemiplegic patients and to investigate the factors that influence on the effectiveness of CIT.

Method: Forty two chronic stroke patients were enrolled and classified into two groups, experimental and control group. The experimental group took CIT for 2 weeks. CIT consisted of restraint of the unaffected upper extremity with massive training of the affected upper extremity. The motor function of patient's upper extremity was assessed by Manual Function Test (MFT) and Jebsen Hand Function Test before treatment, at 2 weeks and at 8 weeks after the treatment.

Results: The withdrawal rate was 46.7% during CIT period. There was substantial significant improvements in MFT and Jebsen Hand Function Test after 2 weeks of treatment in the experimental group (p<0.05). The effects in the experimental group were maintained at 6 weeks after cessation of the treatment.

Conclusion: CIT is considered to be an effective treatment for motor function of the chronic hemiplegic upper extremity motor function, and will be useful as an additional therapeutic tool. (J Korean Acad Rehab Med 2003; 27: 813-818)

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