Objective
To determine whether the bioimpedance analysis (BIA) ratios of upper to lower extremities could predict treatment outcomes after complex decongestive therapy (CDT) for gynecological cancer related lymphedema (GCRL).
Methods
A retrospective study, from March 2015 to December 2018, was conducted. The study sample comprised patients receiving CDT, 30 minutes per day, for 10 days. Bioimpedance was measured pre- and post-CDT. Circumference measurements were obtained at 20 and 10 cm above the knee (AK) and 10 cm below the knee (BK). We calculated the expected impedance at 0 Hz (R0) of extremities and upper/lower extremity R0 ratios (R0_U/L). We evaluated the relationship between R0_U/L and changes in R0_U/L and circumferences, pre- and post-CDT.
Results
Overall, 59 patients were included in this study. Thirty-one lower extremities in 26 patients comprised the acute group, and 38 lower extremities in 33 patients comprised the chronic group. Pre-treatment R0_U/L was significantly correlated with R0_U/L change after adjusting for age and BMI (acute: R=0.513, p<0.01; chronic: R=0.423, p<0.01). In the acute group, pre-treatment R0_U/L showed a tendency to be correlated with circumference change (AK 20 cm: R=0.427, p=0.02; AK 10 cm: R=0.399, p=0.03).
Conclusion
Our study results suggested that pre-treatment BIA could predict volume reductions after CDT in the early stages of GCRL. These findings implied that BIA value could be one possible parameter to apply in treatment outcomes prediction, during the early stage of GCRL. Therefore, further large-scale prospective studies will be beneficial.

Citations

• Efficacy of complex decongestive therapy on venous flow, internal saphenous diameter, edema, fat mass of the limbs and quality of life in patients with chronic venous insufficiency: A randomized clinical trial
  Ana Martín Jiménez, Beatriz María Bermejo Gil, Alejandro Santos-Lozano, Francisco Jose Pinto- Fraga, Carolina García Barroso, Leonardo Raul Vittori, Aurymar Fraino, Héctor Menéndez Alegre
  Journal of Vascular Surgery: Venous and Lymphatic Disorders.2025; 13(2): 102005.     CrossRef
• Comparing the direct effect of lymphatic dynamic transport after lower-level laser therapy in healthy volunteers: a randomized controlled trial
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  Lasers in Medical Science.2025;[Epub]     CrossRef
• Decompression of Axillary Vein: An Essential Adjunct for Advanced Lymphedema
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• Factors Predicting the Effect of a Complex Decongestive Therapy in Patients with Mild Lymphedema Following Mastectomy for Early Stage Breast Cancer
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  Lymphatic Research and Biology.2024; 22(5): 241.     CrossRef
• Lymphedema Index Ratio As Predictive Factor of Treatment in Patients with Breast Cancer-Related Lymphedema
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  Lymphatic Research and Biology.2022; 20(3): 302.     CrossRef
• Recent Trends in Rehabilitation for Cancer Patients
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  Annals of Rehabilitation Medicine.2022; 46(3): 111.     CrossRef
• Update August 2020
  Francine Blei
  Lymphatic Research and Biology.2020; 18(4): 381.     CrossRef