Kyungmin Kim, Sung Hoon Kim, Ji Hyun Kim, Sang Yeol Yong, Won Woo Choi, Sun Jung Kim, Hyuk Do Kim, Kyung Joon Oh, Dae Ryong Kang, Sehwa Hong, Jiseon Hong
Ann Rehabil Med 2024;48(1):50-56. Published online December 12, 2023
Objective To assess the safety and effectiveness of high-density light-emitting diode (LED) irradiation therapy in patients with hand osteoarthritis (OA) and compare the pre- and post-intervention symptoms.
Methods Twenty-three patients with hand OA underwent eight sessions of high-density LED irradiation therapy directed at the five most painful areas in the finger joints. Each session lasted for 18 minutes; and the sessions were conducted twice a week, for 4 weeks. We evaluated the degree of pain using the visual analogue scale, ring size, and passive range of motion (flexion+extension) for two most painful joints from the baseline to post-therapy (weeks 4 and 6).
Results High-density LED irradiation therapy significantly reduced the pain posttreatment compared with that observed at the baseline (p<0.001). Although improvements were observed in ring size and joint range of motion at 4 and 6 weeks, they were not statistically significant (p>0.05). No adverse events were observed.
Conclusion We examined the safety and effectiveness of high-density LED irradiation therapy in reducing pain and hand swelling and improving joint mobility in patients with hand OA. These results suggest that high-density LED irradiation therapy has the potential to be an important strategy for managing hand OA.
Citations
Citations to this article as recorded by
Letter to the Editor: Efficacy and Safety of High Density LED Irradiation Therapy for Patients With Hand Osteoarthritis: A Single-Center Clinical Study Vanshika Agarwal, Jeyanthi. S, Adarsh Sharma Annals of Rehabilitation Medicine.2025; 49(1): 1. CrossRef
Response: Efficacy and Safety of High Density LED Irradiation Therapy for Patients With Hand Osteoarthritis: A Single-Center Clinical Study (Ann Rehabil Med 2024;48:50-6) Jiseon Hong Annals of Rehabilitation Medicine.2025; 49(1): 3. CrossRef
Photobiomodulation Literature Watch December 2023 James D. Carroll Photobiomodulation, Photomedicine, and Laser Surgery.2024; 42(10): 660. CrossRef
Objective To evaluate the efficacy of light-emitting diode (LED) and their dual-wavelengths as a treatment strategy for osteoarthritis.
Methods We induced osteoarthritis in male Sprague-Dawley rats by intra-articular injection of sodium iodoacetate into the right rear knee joint. The animals with lesions were divided into an untreated group and an LED-treated group (n=7 each). In the LED-treated group, the lesioned knee was irradiated with lasers (850 and 940 nm) and dose (3.15 J/cm2) for 20 minutes per session, twice a week for 4 weeks. Knee joint tissues were stained and scanned using an in vivo micro-computed tomography (CT) scanner. Serum interleukin (IL)-6 and IL-18 levels were determined using enzyme-linked immuno-sorbent assay. Several functional tests (lines crossed, rotational movement, rearing, and latency to remain rotating rod) were performed 24 hours before LED treatment and at 7, 14, 21, and 28 days after treatment.
Results LED-treated rats showed improved locomotor function and suppressed matrix-degrading cytokines. Micro-CT images indicated that LED therapy had a preserving effect on cartilage and cortical bone.
Conclusion LED treatment using wavelengths of 850 and 940 nm resulted in significant functional, anatomical, and histologic improvements without adverse events in a rat model. Further research is required to determine the optimal wavelength, duration, and combination method, which will maximize treatment effectiveness.
Citations
Citations to this article as recorded by
Effects of Dual Wavelength Photobiomodulation on Osseointegration in Grafted Areas Lucas de Sousa Goulart Pereira, Julia Raulino Lima, Elcio Marcantonio, Priscilla Barbosa Ferreira Soares, Suzane Cristina Pigossi, Guilherme José Pimentel Lopes de Oliveira Lasers in Surgery and Medicine.2026; 58(5): 429. CrossRef
BTEX-K Ameliorates Rheumatoid Arthritis Through Regulating the NF-κB and PPAR-γ Signaling Pathways in Incomplete Freund’s Adjuvant-Induced Arthritis Mice Joonpyo Hong, Jin-Ho Lee, Ga Young Lee, Jin-Hwan Oh, Hana Lee, Han Sung Kim, Tack-Joong Kim Biomedicines.2025; 13(7): 1524. CrossRef
Photobiomodulation Literature Watch December 2023 James D. Carroll Photobiomodulation, Photomedicine, and Laser Surgery.2024; 42(10): 660. CrossRef
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