Annals of Rehabilitation Medicine

"Seok-Hee Han"

Original Articles

Long-Term Efficacy of Mirabegron Add-On Therapy to Antimuscarinic Agents in Patients With Spinal Cord Injury: Seok-Hee Han, In Kyoung Cho, Joo Hwan Jung, Seong Ho Jang, Bum-Suk Lee; Ann Rehabil Med 2019;43(1):54-61. Published online February 28, 2019; DOI: https://doi.org/10.5535/arm.2019.43.1.54

Abstract
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Objective
To evaluate the long-term efficacy of mirabegron add-on therapy in patients with spinal cord injury (SCI) based on an urodynamic study.
Methods
This retrospective study involved a chart audit of individuals with SCI who underwent two consecutive urodynamic studies between April 1, 2015 and April 1, 2018. After adding 50 mg of mirabegron once a day to the pre-existing antimuscarinic therapy for a period of, at least 6 months, the following variables were analyzed: change in cystometric capacity, change in bladder compliance, change in maximal detrusor pressure, change in reflex volume, and presence of significant leakage during filling cystometry.
Results
A total of 31 participants with a mean age of 41±15 years were included in the analysis. A significant increase in cystometric capacity (mean, 362 to 424 mL; p=0.03), reflex volume (mean, 251 to 329 mL; p=0.02), and bladder compliance (median, 12 to 18 mL/cmH2O; p=0.04) was observed. The presence of leakage during filling cystometry was significantly reduced (29% to 10%; p=0.03). Likewise, a non-significant decrease in the change in maximal detrusor pressure was observed (mean, 31 to 27 cmH2O; p=0.39).
Conclusion
Adding mirabegron to conventional antimuscarinics further improved urodynamic parameters in patients with chronic SCI, and sustained efficacy was observed in long-term use.

Citations

Citations to this article as recorded by

Mirabegron in the treatment of neurogenic detrusor overactivity: pharmacological and clinical aspects
Igor V. Kuzmin
Urology reports (St. - Petersburg).2025; 15(1): 51. CrossRef
Drug Repurposing for Spinal Cord Injury: Progress Towards Therapeutic Intervention for Primary Factors and Secondary Complications
Lahanya Guha, Hemant Kumar
Pharmaceutical Medicine.2023; 37(6): 463. CrossRef
Management of the Devastated Female Urethra
Anne Shirley Hoselton, Paige Kuhlmann, Ramy Goueli
Current Bladder Dysfunction Reports.2023; 18(4): 293. CrossRef
Bowel and Bladder Care in Patients With Spinal Cord Injury
Eren O. Kuris, Daniel Alsoof, Camilo Osorio, Alan H. Daniels
Journal of the American Academy of Orthopaedic Surgeons.2022; 30(6): 263. CrossRef
Urological Care After Spinal Cord Injury
Gamal Ghoniem, Dena Moskowitz, Catherine Nguyen
Current Physical Medicine and Rehabilitation Reports.2022; 10(2): 89. CrossRef
Efficacy and safety of mirabegron for treatment of neurogenic detrusor overactivity in adults with spinal cord injury or multiple sclerosis: a systematic review
Yesim Akkoc
Spinal Cord.2022; 60(10): 854. CrossRef
Urogenital dysfunction following neurotrauma
Udit Saraf, Anand Kumar A, Jalesh N. Panicker
Current Opinion in Neurology.2022; 35(6): 753. CrossRef

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Prosody Processing of Korean Language in Stroke Patients: A Preliminary Study: Hye-In Ju, Yong-Wook Shin, Seok-Hee Han, Jeom-Sook Kim, Hye-Young Choi, Hye-Sun Lee, Thine Yang, Joon-Ho Shin; Ann Rehabil Med 2013;37(5):642-648. Published online October 29, 2013; DOI: https://doi.org/10.5535/arm.2013.37.5.642

Abstract
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Objective

To investigate the hemispheric contributions to prosody recognitions and interference effects of semantic processing on prosody for stroke patients by using the Korean language.

Methods

Ten right hemisphere damaged patients (RHD), nine left hemisphere damaged patients (LHD), and eleven healthy controls (HC) participated. In pure prosody recognition task, four semantically neutral sentences were selected and presented in both sad and happy prosodies. In interference task, participants listened to emotionally intoned sentences in which the semantic contents were congruent or incongruent with prosody. Participants were asked to rate the valence of prosody while ignoring the semantic contents, and thus, reaction time and accuracy were estimated.

Results

In pure prosody recognition task, RHD showed low accuracy as compared to HC (p=0.013), and the tendency of group response showed that RHD performed worse than HC and LHD with regards to accuracy and reaction time. In interference task, analysis of accuracy revealed a significant main effect of groups (p=0.04), and the tendency implied that RHD is less accurate as compared to LHD and HC. The RHD took longer reaction times than HC in congruent and incongruent items (p<0.001).

Conclusion

Right hemispheric laterality to prosody processing of Korean language in stroke patients was observed. Interference effects of semantic contents to prosody processing were not observed, which suggested unique characteristics of prosody for Korean language. These results could be referred as preliminary data for future researches on Korean languages.