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"Seihee Yoon"

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"Seihee Yoon"

Original Articles
Efficacy and Safety of Intra-articular Injections of Hyaluronic Acid Combined With Polydeoxyribonucleotide in the Treatment of Knee Osteoarthritis
Seihee Yoon, Jung Joong Kang, Jungin Kim, Seunghun Park, Jong Moon Kim
Ann Rehabil Med 2019;43(2):204-214.   Published online April 30, 2019
DOI: https://doi.org/10.5535/arm.2019.43.2.204
Objective
To assess the clinical efficacy and safety of intra-articular injection of hyaluronic acid (HA) combined with polydeoxyribonucleotide (PDRN) in patients with knee osteoarthritis in comparison with that of HA alone.
Methods
The current single-center, prospective, randomized, double-blind, controlled study was conducted in 36 patients with knee osteoarthritis at our medical institution. All the eligible patients (n=30) were equally assigned to two treatment arms (trial group ‘HA+PDRN’ and control group ‘HA’). For efficacy assessment, the patients were evaluated for the visual analogue scale (VAS) scores, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Knee Society Scores (KSS), all of which served as efficacy outcome measures. We monitored time-dependent changes in efficacy outcome measures at baseline and 1, 3 and 6 months. Subsequently, we compared differences in changes in efficacy outcome measures at 6 months from baseline between the two groups. Moreover, we assessed the safety based on the treatment-emergent adverse events (TEAEs), adverse drug reactions (ADRs) and any other complications serving as safety outcome measures.
Results
There were significant differences in changes in the VAS scores, the WOMAC scores in all domains, except ‘Stiffness’, the total WOMAC scores, and the KSS scores in all the domains at 6 months from baseline between the two groups (p<0.05). In our series, there were no TEAEs, ADRs, and any other complications.
Conclusion
Intra-articular injections of HA combined with PDRN can also be considered in the treatment of knee osteoarthritis. However, further large-scale and multi-center studies are required to demonstrate the potential of the proposed combination.

Citations

Citations to this article as recorded by  
  • Emerging wound-healing injectable polydeoxyribonucleotide: potential as a prohibited doping method and its simple detection via CRISPR/Cas12a system
    Joon-Yeop Yi, Sanghwa Park, Minyoung Kim, Yujin Jeong, HyunA Shin, Yeojeong Cho, Mijin Jeon, Min-Kyu Oh, Changmin Sung
    International Journal of Biological Macromolecules.2025; 309: 142999.     CrossRef
  • Points to ponder on the role of polynucleotides in regenerative and aesthetic medicine: a systematic review
    William Richard Webb, Eqram Rahman, Parinitha Rao, Hany Niamey Abu-Farsakh, Nanze Yu, Patricia E. Garcia, Sotirios Ioannidis, Karim Sayed, Elias Tam, Wolfgang G. Philipp-Dormston, Mohammad Najlah, Zakia Rahman, Jean D. A. Carruthers, Ash Mosahebi
    European Journal of Plastic Surgery.2024;[Epub]     CrossRef
  • An injectable hyaluronic acid-Polydeoxyribonucleotides (HA-PDRN) crosslinked hydrogel as a dermal filler
    Guo jiahong, Fang wei, Wang feifei
    European Polymer Journal.2024; 219: 113395.     CrossRef
  • Recent advances on polydeoxyribonucleotide extraction and its novel application in cosmeceuticals
    Thi Hanh Nguyen, San-Lang Wang, Van Bon Nguyen
    International Journal of Biological Macromolecules.2024; 282: 137051.     CrossRef
  • Injectable “Skin Boosters” in Aging Skin Rejuvenation: A Current Overview
    Nark-Kyoung Rho, Hyun-Seok Kim, Soo-Young Kim, Won Lee
    Archives of Plastic Surgery.2024; 51(06): 528.     CrossRef
  • Clinical Updates in Polydeoxyribonucleotide Injection
    Tae-Yeong Kim, Yong-Tae Kim, Jung-Taek Hwang
    Journal of the Korean Orthopaedic Association.2024; 59(6): 386.     CrossRef
  • Pseudoseptic Reaction to an Intra-Articular Polydeoxyribonucleotide Injection into the Ankle: A Case Report
    Seungcheol Yu, Hangaram Kim, Youngwoong Choi, Jeongsoo Kim
    International journal of Pain.2024; 15(2): 106.     CrossRef
  • Intra-articular injections of polynucleotides for joint preconditioning before the injections of bionic cross-link hyaluronic acid. Case report
    Irina S. Svintsitskaya, Konstantin Yu. Volkov, Aleksei Chetaikin Storm
    Terapevticheskii arkhiv.2024; 96(12): 1238.     CrossRef
  • Therapeutic effects of polydeoxyribonucleotide in an in vitro neuronal model of ischemia/reperfusion injury
    Seongmoon Jo, Ahreum Baek, Yoonhee Cho, Sung Hoon Kim, Dawoon Baek, Jihye Hwang, Sung-Rae Cho, Hyun Jung Kim
    Scientific Reports.2023;[Epub]     CrossRef
  • Skin boosters – The upcoming boom in cosmetic dermatology for healthy skin
    Maya Vedamurthy, Vaishnavi Duvvuru, Vijaya Lakshmi Chelikani
    Cosmoderma.2023; 3: 82.     CrossRef
  • Role and Effectiveness of Intra-articular Injection of Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Systematic Review
    Sumant Chavda, Syed Arman Rabbani, Tarun Wadhwa
    Cureus.2022;[Epub]     CrossRef
  • Polydeoxyribonucleotide: A promising skin anti-aging agent
    Aawrish Khan, Guobao Wang, Feng Zhou, Lunli Gong, Jun Zhang, Lili Qi, Haiyan Cui
    Chinese Journal of Plastic and Reconstructive Surgery.2022; 4(4): 187.     CrossRef
  • Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates short-term memory impairment by suppressing cerebral ischemia-induced inflammation via MAPK pathway
    Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Chang-Ju Kim, Jung Won Jeon, Jun-Young Chung, Jin Hee Han, Giuseppe Pignataro
    PLOS ONE.2021; 16(3): e0248689.     CrossRef
  • Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering
    Tae-Hee Kim, Seong-Yeong Heo, Gun-Woo Oh, Soo-Jin Heo, Won-Kyo Jung
    Marine Drugs.2021; 19(6): 296.     CrossRef
  • Mesenchymal Stem Cells Use in the Treatment of Tendon Disorders: A Systematic Review and Meta-Analysis of Prospective Clinical Studies
    Woo Sup Cho, Sun Gun Chung, Won Kim, Chris H. Jo, Shi-Uk Lee, Sang Yoon Lee
    Annals of Rehabilitation Medicine.2021; 45(4): 274.     CrossRef
  • Viscosupplementation in the Therapy for Osteoarthritic Knee
    Junghyun Park, Hue Jung Park, Min Cheol Rho, Jin Joo
    Applied Sciences.2021; 11(24): 11621.     CrossRef
  • A Comprehensive Review of Viscosupplementation in Osteoarthritis of the Knee
    Jacquelin Peck, Annabel Slovek, Paulo Miro, Neeraj Vij, Blake Traube, Christopher Lee, Amnon A. Berger, Hisham Kassem, Alan D. Kaye, William F. Sherman, Alaa Abd-Elsayed
    Orthopedic Reviews.2021;[Epub]     CrossRef
  • Polydeoxyribonucleotide Regulation of Inflammation
    Maria Teresa Colangelo, Carlo Galli, Stefano Guizzardi
    Advances in Wound Care.2020; 9(10): 576.     CrossRef
  • The efficacy and safety of polydeoxyribonucleotide for the treatment of knee osteoarthritis
    Man Soo Kim, Ryu Kyoung Cho, Yong In
    Medicine.2019; 98(39): e17386.     CrossRef
  • 12,612 View
  • 489 Download
  • 15 Web of Science
  • 19 Crossref
Efficacy and Safety of Caregiver-Mediated Exercise in Post-stroke Rehabilitation
Min Jun Lee, Seihee Yoon, Jung Joong Kang, Jungin Kim, Jong Moon Kim, Jun Young Han
Ann Rehabil Med 2018;42(3):406-415.   Published online June 27, 2018
DOI: https://doi.org/10.5535/arm.2018.42.3.406
Objective
To assess the efficacy and safety of our 4-week caregiver-mediated exercise (CME) in improving trunk control capacity, gait, and balance and in decreasing concerns about post-stroke falls when there is an increase in its efficacy.
Methods
Acute or subacute stroke survivors were assigned to either the trial group (n=35) or the control group (n=37). Changes in Modified Barthel Index (MBI), Functional Ambulation Categories (FAC), Berg Balance Scale (BBS), and Trunk Impairment Scale (TIS) scores at 4 weeks from baseline served as primary outcome measures. Correlations of primary outcome measures with changes in Fall Efficacy Scale-International (FES-I) scores at 4 weeks from baseline in the trial group served as secondary outcome measures. Treatment-emergent adverse events (TEAEs) served as safety outcome measures.
Results
There were significant differences in changes in MBI, FAC, BBS, TIS-T, TIS-D, TIS-C, and FES-I scores at 4 weeks from baseline between the two groups (all p<0.0001). There were no significant (p=0.0755) differences in changes in TIS-S scores at 4 weeks from baseline between the two groups. MBI, FAC, BBS, and TIS scores showed significantly inverse correlations with FES-I scores in patients receiving CME. There were no TEAEs in our series.
Conclusion
CME was effective and safe in improving the degree of independence, ambulation status, dynamic and static balance, trunk function, and concerns about post-stroke falls in stroke survivors.

Citations

Citations to this article as recorded by  
  • Physical rehabilitation approaches for the recovery of function and mobility following stroke
    Alex Todhunter-Brown, Ceri E Sellers, Gillian D Baer, Pei Ling Choo, Julie Cowie, Joshua D Cheyne, Peter Langhorne, Julie Brown, Jacqui Morris, Pauline Campbell
    Cochrane Database of Systematic Reviews.2025;[Epub]     CrossRef
  • Effects of Real-Time Feedback Methods on Static Balance Training in Stroke Patients: A Randomized Controlled Trial
    Il-Ho Kwon, Won-Seob Shin, Kyu-Seong Choi, Myung-Sun Lee
    Healthcare.2024; 12(7): 767.     CrossRef
  • Impact of telehealth on stroke survivor–caregiver dyad in at‐home rehabilitation: A systematic review
    Davide Bartoli, Antonello Petrizzo, Ercole Vellone, Rosaria Alvaro, Gianluca Pucciarelli
    Journal of Advanced Nursing.2024; 80(10): 4003.     CrossRef
  • Stroke survivor and caregiver experiences of virtual reality gaming to promote social participation: A qualitative study
    Suzanne Hoi Shan Lo, Janita Pak Chun Chau, Kai Chow Choi, Laveeza Butt, Alexander Yuk Lun Lau, Vivian Wing Yan Lee, Eddie Chi Fai Kwok, David R. Thompson, Nadinne Alexandra Roman
    PLOS ONE.2024; 19(12): e0315826.     CrossRef
  • Physical activity according to sit-to-stand, standing, and stand-to-sit abilities in subacute stroke with walking difficulty: a cross-sectional study
    Natsuki Shimizu, Hiroyuki Hashidate, Tomohiro Ota, Yumi Kawai
    Physiotherapy Theory and Practice.2023; 39(11): 2327.     CrossRef
  • Anosognosia for Hemiplegia and Falls After Stroke
    Elizabeth M. Byrd, Christianne E. Strang, Xiaofei Qiao, Lori Loan, Rebecca S. Miltner, Rita A. Jablonski
    Rehabilitation Nursing.2023; 48(1): 14.     CrossRef
  • Effectiveness of caregiver‐mediated exercise interventions on activities of daily living, anxiety and depression post‐stroke rehabilitation: A systematic review and meta‐analysis
    Wen Ting Choo, Ying Jiang, Kendy Gui Fang Chan, Hadassah Joann Ramachandran, Jun Yi Claire Teo, Chuen Wei Alvin Seah, Wenru Wang
    Journal of Advanced Nursing.2022; 78(7): 1870.     CrossRef
  • Exercise participation and promotion in the multiple sclerosis community; perspectives across varying socio-ecological levels
    Yvonne C. Learmonth, Zita Chan, Helen Correia, Dave Hathorn, Allan Kermode, Catherine Smith, Diana Walker
    Disability and Rehabilitation.2021; 43(25): 3623.     CrossRef
  • Continuity of Care During COVID-19 Lockdown: A Survey on Stakeholders' Experience With Telerehabilitation
    Carla Assenza, Hilenia Catania, Clementina Antenore, Tiziana Gobbetti, Paola Gentili, Stefano Paolucci, Daniela Morelli
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • The effects of virtual reality augmented robot-assisted gait training on dual-task performance and functional measures in chronic stroke: a randomized controlled single-blind trial
    Büşra KAYABINAR, İpek ALEMDAROĞLU-GÜRBÜZ, Öznur YILMAZ
    European Journal of Physical and Rehabilitation Medicine.2021;[Epub]     CrossRef
  • Physical fitness training for stroke patients
    David H Saunders, Mark Sanderson, Sara Hayes, Liam Johnson, Sharon Kramer, Daniel D Carter, Hannah Jarvis, Miriam Brazzelli, Gillian E Mead
    Cochrane Database of Systematic Reviews.2020;[Epub]     CrossRef
  • Developing ActivABLES for community-dwelling stroke survivors using the Medical Research Council framework for complex interventions
    Steinunn A. Olafsdottir, Helga Jonsdottir, Charlotte Magnusson, Héctor Caltenco, Mikko Kytö, Laura Maye, David McGookin, Ingibjörg Bjartmarz, Solveig Asa Arnadottir, Ingibjörg Hjaltadottir, Thora B. Hafsteinsdottir
    BMC Health Services Research.2020;[Epub]     CrossRef
  • Feasibility of ActivABLES to promote home-based exercise and physical activity of community-dwelling stroke survivors with support from caregivers: A mixed methods study
    Steinunn A. Olafsdottir, Helga Jonsdottir, Ingibjörg Bjartmarz, Charlotte Magnusson, Héctor Caltenco, Mikko Kytö, Laura Maye, David McGookin, Solveig Asa Arnadottir, Ingibjörg Hjaltadottir, Thora B. Hafsteinsdottir
    BMC Health Services Research.2020;[Epub]     CrossRef
  • The effects of sitting Tai Chi on physical and psychosocial health outcomes among individuals with impaired physical mobility
    Jie Zhao, Janita Pak Chun Chau, Yuli Zang, Suzanne Hoi Shan Lo, Kai Chow Choi, Surui Liang
    Medicine.2020; 99(34): e21805.     CrossRef
  • 11,875 View
  • 230 Download
  • 13 Web of Science
  • 14 Crossref
Research Designs and Statistical Methods Trends in the Annals of Rehabilitation Medicine
Jinmo Kim, Seihee Yoon, Jung Joong Kang, Kyunghwa Han, Jong Moon Kim, Shin Kyoung Kim
Ann Rehabil Med 2017;41(3):475-482.   Published online June 29, 2017
DOI: https://doi.org/10.5535/arm.2017.41.3.475
Objective

To investigate trends of the research designs and statistical methods in the Annals of Rehabilitation Medicine (ARM) published from 2005 to 2015 through a comparison of articles with the Archives of Physical Medicine and Rehabilitation (APMR).

Methods

The authors reviewed all articles published in ARM and APMR for the years 2005 and 2015 in order to determine their research designs as well as their statistical methods used in each article.

Results

In ARM, randomized controlled trials increased from 4.5% in 2005 to 6.5% in 2015. In APMR, randomized controlled trials increased from 8.1% in 2005 to 14.0% in 2015, meta-analyses increased to 5.3%, and systematic reviews increased to 6%. The number of studies using statistical methods increased in ARM from 1.9 to 2.6 per article and in APMR, from 2.7 to 3.1. Use of advanced methods in ARM also showed an increase from 2005 to 2015.

Conclusion

This study concludes that there is a trend of increased awareness and attempts to use varied research approaches in ARM articles. There should also be more in-depth discussions and opportunities for researchers to share their experiences regarding statistical methods in the clinical field.

Citations

Citations to this article as recorded by  
  • Therapeutic Effect of Nanotitanium Oxide Combined with Exercise Rehabilitation Training on Wrist Joint Injury of Boxers
    Xiaohua Li, Jianbo Li, Meifang Zhang, Awais Ahmed
    Journal of Nanomaterials.2022;[Epub]     CrossRef
  • Methodological Issues in Rehabilitation Research: A Scoping Review
    Chiara Arienti, Susan Armijo-Olivo, Silvia Minozzi, Lisa Tjosvold, Stefano Giuseppe Lazzarini, Michele Patrini, Stefano Negrini
    Archives of Physical Medicine and Rehabilitation.2021; 102(8): 1614.     CrossRef
  • A Bibliometric Analysis Using Alternative Metrics for Articles in the Annals of Rehabilitation Medicine
    Seok Cheol Han, Hyo Jung Kang, Won Jae Lee, Hee Sup Chung, Jong Hyuk Lee
    Annals of Rehabilitation Medicine.2020; 44(2): 158.     CrossRef
  • Data Science in Physical Medicine and Rehabilitation
    Kenneth J. Ottenbacher, James E. Graham, Steve R. Fisher
    Physical Medicine and Rehabilitation Clinics of North America.2019; 30(2): 459.     CrossRef
  • Trends in statistical methods in articles published in Archives of Plastic Surgery between 2012 and 2017
    Kyunghwa Han, Inkyung Jung
    Archives of Plastic Surgery.2018; 45(03): 207.     CrossRef
  • 5,532 View
  • 83 Download
  • 6 Web of Science
  • 5 Crossref
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