Objective
To assess the impact of a “one-stop”, multi-modal, hospital-associated-home-based prehabilitation model, helmed by a small core team, on newly diagnosed gastrointestinal and urological cancer patients planned for surgery.
Methods
This is a retrospective study in a tertiary public hospital, involving all newly diagnosed gastrointestinal and urological cancer patients planned for surgery. The primary outcome measure was the 6-minute walk test (6MWT). Other outcomes included physical, psychological and quality-of-life measures, and patient satisfaction surveys, taken at baseline, pre-operatively (post-prehabilitation), and at 3 months post-operatively.
Results
When comparing the baseline to pre-operatively (post-prehabilitation), there was a statistically significant improvement in the 6MWT (21.52 m, p<0.001), 30-Second Sit to Stand test (STS) (1.08 repetitions, p<0.001), Timed Up and Go test (TUG) (0.83 seconds, p=0.014) and Hospital Anxiety and Depression Scale (HADS) (total score 1.77, p<0.001). These were sustained (6MWT: 0.22, p=0.964; STS: 0.08 repetitions, p=0.863; TUG: 0.04 seconds, p=0.939) or further improved (HADS total score 2.06, p=0.003) at 3 months post-operatively. There was also a statistically significant improvement in the EuroQol-5 dimension health score (health-related quality-of-life measure) from baseline to 3 months post-operatively (7.04 points, p=0.001), with more than 90% overall patient satisfaction reported.
Conclusion
Prehabilitation applied via our model resulted in significant improvements in functional capacity, psychological and quality-of-life outcomes, sustained at 3 months post-operatively, and is a feasible and effective approach that is well-received by our patients.

Citations

• Effects of a functional training prehabilitation program supported by the Prehab® App on functional capacity in preoperative oncological patients
  Monique Messaggi-Sartor, Raquel Sebio Garcia, Marta Amor-Barbosa, David Blanco, Graciela Martinez-Pallí
  Supportive Care in Cancer.2026;[Epub]     CrossRef
• A prototype smartwatch for monitoring dynamic, compound and plyometric exercises in cancer prehabilitation: a development and validation study
  San San Tay, Hanushyah Devi, Shannon Yap, Abbas Bin Zainul Abideen, Xuan Han Koh, Daniel Leong
  Frontiers in Digital Health.2026;[Epub]     CrossRef
• Feasibility, User Acceptance, and Outcomes of Using a Cancer Prehabilitation App for Exercise: Pilot Cohort Study
  Fuquan Zhang, Deepali Bang, Christine Alejandro Visperas, Mon Hnin Tun, San San Tay
  JMIR Formative Research.2025; 9: e64427.     CrossRef
• Participation and Adherence to Prehabilitation Programs for Colorectal Cancer
  Misha Sier, Eva Godina, Omar Mollema, Maud Cox, Thais Tweed, Jan Greve, Jan Stoot
  Nutrients.2025; 17(11): 1792.     CrossRef
• Measures of preoperative anxiety: Part two
  Katarzyna Nowicka-Sauer, Adam Zemła, Dorota Banaszkiewicz, Bartosz G. Trzeciak, Krzysztof Jarmoszewicz
  Anaesthesiology Intensive Therapy.2024; 56(1): 9.     CrossRef
• Prevention and treatment of noncognitive complications
  André van Zundert, Stephen P. Gatt, Tom Christophe van Zundert
  Saudi Journal of Anaesthesia.2023; 17(4): 557.     CrossRef