Annals of Rehabilitation Medicine

"Kyung-A Shin"

Original Articles

Effects of Long-Distance Running on Cardiac Markers and Biomarkers in Exercise-Induced Hypertension Runners: An Observational Study: Min-ho Park, Kyung-A Shin, Chul-Hyun Kim, Yoon-Hee Lee, Yongbum Park, Jaeki Ahn, Young-Joo Kim; Ann Rehabil Med 2018;42(4):575-583. Published online August 31, 2018; DOI: https://doi.org/10.5535/arm.2018.42.4.575

Abstract
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Objective
To investigate changes of cardiac and muscle damage markers in exercise-induced hypertension (EIH) runners before running (pre-race), immediately after completing a 100-km ultramarathon race, and during the recovery period (24, 72, and 120 hours post-race).
Methods
In this observational study, volunteers were divided into EIH group (n=11) whose maximum systolic blood pressure was ≥210 mmHg in graded exercise testing and normal exercise blood pressure response (NEBPR) group (n=11). Their blood samples were collected at pre-race, immediately after race, and at 24, 72, and 120 hours post-race.
Results
Creatine kinase (CK) and cardiac troponin I (cTnI) levels were significantly higher in EIH group than those in the NEBPR group immediately after race and at 24 hours post-race (all p<0.05). However, lactate dehydrogenase (LDH), creatine kinase-myocardial band (CKMB), or CKMB/CK levels did not show any significant differences between the two groups in each period. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were significantly higher in EIH group than those in NEBPR group immediately after race and at 24 and 72 hours postrace (all p<0.05). A high sensitivity C-reactive protein (hs-CRP) level was significantly higher in EIH group than that in NEBPR group at 24 hours post-race (p<0.05).
Conclusion
The phenomenon of higher inflammatory and cardiac marker levels in EIH group may exaggerate cardiac volume pressure and blood flow restrictions which in turn can result in cardiac muscle damage. Further prospective studies are needed to investigate the chronic effect of such phenomenon on the cardiovascular system in EIH runners.

Citations

Citations to this article as recorded by

Prognostic value of exercise blood pressure: role of fitness and exercise training
Jonathan W. Hoch, Christin Domeier, Pannonica Silvestri, Joseph C. Watso
American Journal of Physiology-Heart and Circulatory Physiology.2026; 330(4): H1025. CrossRef
Asymptomatic HyperCKemia: A Case Report and Literature Review
成锋李
Advances in Clinical Medicine.2025; 15(07): 408. CrossRef
Possible Mechanisms for Adverse Cardiac Events Caused by Exercise-Induced Hypertension in Long-Distance Middle-Aged Runners: A Review
Young-Joo Kim, Kyoung-Min Park
Journal of Clinical Medicine.2024; 13(8): 2184. CrossRef
Relationship between echocardiographic characteristics and cardiac biomarkers during long-distance trail running
Romain Jouffroy, Hélène Hergault, Juliana Antero, Antoine Vieillard Baron, Nicolas Mansencal
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef
Electrical Cardiometry and Cardiac Biomarkers in 24-h and 48-h Ultramarathoners
Che-Hung Liu, Li-Hua Li, Ming-Long Chang, Wei-Fong Kao, Chorng-Kuang How, Jiun-I Lai, Yen-Kuang Lin, Yu-Hui Chiu, Wen-Han Chang
International Journal of Sports Medicine.2021; 42(11): 1035. CrossRef
Exercise-Induced Cardiac Troponin Elevations: From Underlying Mechanisms to Clinical Relevance
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Circulation.2021; 144(24): 1955. CrossRef
Long‐term biological variability and the generation of a new reference interval for plasma N‐terminal pro‐B‐type natriuretic peptide in Labrador retrievers
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Journal of Small Animal Practice.2020; 61(6): 368. CrossRef
Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon
Aleksandra Żebrowska, Zbigniew Waśkiewicz, Pantelis T. Nikolaidis, Rafał Mikołajczyk, Damian Kawecki, Thomas Rosemann, Beat Knechtle
Journal of Clinical Medicine.2019; 8(1): 57. CrossRef
Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation
Øyunn Kleiven, Torbjørn Omland, Øyvind Skadberg, Tor Harald Melberg, Magnus Friestad Bjørkavoll-Bergseth, Bjørn Auestad, Rolf Bergseth, Ole Jakob Greve, Kristin Moberg Aakre, Stein Ørn
International Journal of Cardiology.2019; 283: 1. CrossRef

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Effect of Ultra-marathon (308 km) Race on Bone Metabolism and Cartilage Damage Biomarkers: Kyung-A Shin, Al-Chan Kim, Young-Joo Kim, Yoon-Hee Lee, Young-Oh Shin, Sang-Hoon Kim, Young-Sik Park, Hee Seung Nam, Taikon Kim, Hyoung Seop Kim, Yongbum Park; Ann Rehabil Med 2012;36(1):80-87. Published online February 29, 2012; DOI: https://doi.org/10.5535/arm.2012.36.1.80

Abstract
PDF

Objective

To evaluate the potential effects of a 308-km ultra-marathon on bone and cartilage biomarkers.

Method

Venous blood samples were collected at pre-race, 100 km, 200 km, and 308 km checkpoints. The following markers of cartilage damage and bone metabolism were studied: osteocalcin (OC), osteoprotegerin (OPG), and calcium, phosphorous, and cartilage oligomeric matrix protein (COMP).

Results

Blood samples were taken from 20 male runners at four different checkpoints. Serum COMP was increased by 194.1% (130.7% at 100 km and 160.4% at 200 km). Serum OPG was significantly increased by 158.57% at 100 km and 114.1% at 200 km compared to the pre-race measures. OC was transiently suppressed at 200 km. Serum calcium and phosphorous concentrations decreased compared to the pre-race measures.

Conclusion

This study showed that the 308-km ultra-marathon induced several changes, including transient uncoupling of bone metabolism, increased bone resorption, suppressed bone formation, and bone turnover and had a major impact on cartilage structure.

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