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"Kee-Boem Park"

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"Kee-Boem Park"

Original Articles
Effects of Copy Number Variations on Developmental Aspects of Children With Delayed Development
Kee-Boem Park, Kyung Eun Nam, Ah-Ra Cho, Woori Jang, Myungshin Kim, Joo Hyun Park
Ann Rehabil Med 2019;43(2):215-223.   Published online April 30, 2019
DOI: https://doi.org/10.5535/arm.2019.43.2.215
Objective
To determine effects of copy number variations (CNV) on developmental aspects of children suspected of having delayed development.
Methods
A retrospective chart review was done for 65 children who underwent array-comparative genomic hybridization after visiting physical medicine & rehabilitation department of outpatient clinic with delayed development as chief complaints. Children were evaluated with Denver Developmental Screening Test II (DDST-II), Sequenced Language Scale for Infants (SELSI), or Preschool Receptive-Expressive Language Scale (PRES). A Mann-Whitney U test was conducted to determine statistical differences of developmental quotient (DQ), receptive language quotient (RLQ), and expressive language quotient (ELQ) between children with CNV (CNV(+) group, n=16) and children without CNV (CNV(–) group, n=37).
Results
Of these subjects, the average age was 35.1 months (mean age, 35.1±24.2 months). Sixteen (30.2%) patients had copy number variations. In the CNV(+) group, 14 children underwent DDST-II. In the CNV(–) group, 29 children underwent DDSTII. Among variables, gross motor scale was significantly (p=0.038) lower in the CNV(+) group compared with the CNV(–) group. In the CNV(+) group, 5 children underwent either SELSI or PRES. In the CNV(–) group, 27 children underwent above language assessment examination. Both RLQ and ELQ were similar between the two groups.
Conclusion
The gross motor domain in DQ was significantly lower in children with CNV compared to that in children without CNV. This result suggests that additional genetic factors contribute to this variability. Active detection of genomic imbalance could play a vital role when prominent gross motor delay is presented in children with delayed development.

Citations

Citations to this article as recorded by  
  • Complex de novo tetrasomy and trisomy of 2p22.2 involving EIF2AK2 in a child with global developmental delay: a case report and literature review
    Jun Wang, Xin Duan, Chaolong Xu, Tianyu Song, Danmin Shen, Fang Fang
    Frontiers in Pediatrics.2026;[Epub]     CrossRef
  • Novel JAG1 variants leading to Alagille syndrome in two Chinese cases
    Xiufang Feng, Jiangyuan Ping, Shan Gao, Dong Han, Wenxia Song, Xiaoze Li, Yilun Tao, Lihong Wang
    Scientific Reports.2024;[Epub]     CrossRef
  • Copy Number Variation and Structural Genomic Findings in 116 Cases of Sudden Unexplained Death between 1 and 28 Months of Age
    Catherine A. Brownstein, Elise Douard, Robin L. Haynes, Hyun Yong Koh, Alireza Haghighi, Christine Keywan, Bree Martin, Sanda Alexandrescu, Elisabeth A. Haas, Sara O. Vargas, Monica H. Wojcik, Sébastien Jacquemont, Annapurna H. Poduri, Richard D. Goldstei
    Advanced Genetics.2023;[Epub]     CrossRef
  • Copy number variation of the ZNF679 gene in cattle and its association analysis with growth traits
    Xingya Song, Xinmiao Li, Xian Liu, Zijing Zhang, Xiaoting Ding, Yanan Chai, Zhiming Li, Hongli Wang, Jungang Li, Huifeng Liang, Xiaoyan Sun, Guojie Yang, Zengfang Qi, Fuying Chen, Qiaoting Shi, Eryao Wang, Baorui Ru, Chuzhao Lei, Hong Chen, Wujun Liu, Yon
    Animal Biotechnology.2023; 34(9): 4680.     CrossRef
  • Incorporating CNV analysis improves the yield of exome sequencing for rare monogenic disorders—an important consideration for resource-constrained settings
    Nadja Louw, Nadia Carstens, Zané Lombard
    Frontiers in Genetics.2023;[Epub]     CrossRef
  • CNV profiles of Chinese pediatric patients with developmental disorders
    Haiming Yuan, Shaofang Shangguan, Zhengchang Li, Jingsi Luo, Jiasun Su, Ruen Yao, Shun Zhang, Chen Liang, Qian Chen, Zhijie Gao, Yanli Zhu, Shujie Zhang, Wei Li, Weiliang Lu, Yu Zhang, Hua Xie, Fang Liu, Qingming Wang, Yangyang Lin, Liying Liu, Xiuming Wa
    Genetics in Medicine.2021; 23(4): 669.     CrossRef
  • Copy Number Variation: Methods and Clinical Applications
    Ondrej Pös, Jan Radvanszky, Jakub Styk, Zuzana Pös, Gergely Buglyó, Michal Kajsik, Jaroslav Budis, Bálint Nagy, Tomas Szemes
    Applied Sciences.2021; 11(2): 819.     CrossRef
  • 9,441 View
  • 115 Download
  • 5 Web of Science
  • 7 Crossref
The Korean Version of the Cognitive Assessment Scale for Stroke Patients (K-CASP): A Reliability and Validity Study
Kwon-Hee Park, Hee-Won Lee, Kee-Boem Park, Jin-Youn Lee, Ah-Ra Cho, Hyun-Mi Oh, Joo Hyun Park
Ann Rehabil Med 2017;41(3):362-375.   Published online June 29, 2017
DOI: https://doi.org/10.5535/arm.2017.41.3.362
Objective

To develop the Korean version of the Cognitive Assessment Scale for Stroke Patients (K-CASP) and to evaluate the test reliability and validity of the K-CASP in stroke patients.

Methods

The original CASP was translated into Korean, back-translated into English, then reviewed and compared with the original version. Thirty-three stroke patients were assessed independently by two examiners using the K-CASP twice, with a one-day interval, for a total of four test results. To evaluate the reliability of the K-CASP, intra-class correlation coefficients were used. Pearson correlations were calculated and simple regression analyses performed with the Korean version of Mini-Mental State Examination (K-MMSE) and the aphasia quotient (AQ) to assess the validity.

Results

The mean score was 24.42±9.47 (total score 36) for the K-CASP and 21.50±7.01 (total score 30) for the K-MMSE. The inter-rater correlation coefficients of the K-CASP were 0.992 on the first day and 0.995 on the second day. The intra-rater correlation coefficients of the K-CASP were 0.997 for examiner 1 and 0.996 for examiner 2. In the Pearson correlation analysis, the K-CASP score significantly correlated with the K-MMSE score (r=0.825, p<0.001). The coefficients of determination (r2) of the AQ were 0.586 for the K-MMSE and 0.513 for the K-CASP in the simple regression analysis.

Conclusion

The K-CASP is a reliable and valid instrument for cognitive dysfunction screening in post-stroke patients. It is more applicable than other cognitive assessment tools in stroke patients with aphasia.

Citations

Citations to this article as recorded by  
  • Cognitive assessment of post-stroke patients with and without aphasia: The Hebrew version of the Cognitive Assessment for Stroke Patients (CASP) vs. the Montreal Cognitive Assessment (MoCA)
    Naama Rosenheck, Asnat Bar-Haim Erez, Michal Biran
    Applied Neuropsychology: Adult.2026; 33(2): 474.     CrossRef
  • Reliability and validity of the Cognitive Assessment for Stroke Patients (Chinese version) for patients with nonaphasic stroke
    Li-Sha Xiang, Yi Zhang, Fan Xie, Xiao Fei, Ya Wang, Yue Shi
    Applied Neuropsychology: Adult.2025; 32(6): 1595.     CrossRef
  • The Turkish version of the cognitive assessment scale for stroke patients (CASP-TR): a reliability and validity
    Özlem Öge-Daşdöğen, Serkan Bengisu, Hatice Yelda Yıldız, Yakup Krespi
    Aphasiology.2025; 39(9): 1219.     CrossRef
  • Quality of Assessment Tools for Aphasia: A Systematic Review
    Francescaroberta Panuccio, Giulia Rossi, Anita Di Nuzzo, Ilaria Ruotolo, Giada Cianfriglia, Rachele Simeon, Giovanni Sellitto, Anna Berardi, Giovanni Galeoto
    Brain Sciences.2025; 15(3): 271.     CrossRef
  • The influence of language comprehension proficiency on assessment of global cognitive impairment following Acquired Brain Injury: A comparison between MMSE, MoCA and CASP batteries
    Davide Crivelli, Claudia Spinosa, Maria Teresa Angelillo, Michela Balconi
    Applied Neuropsychology: Adult.2023; 30(5): 546.     CrossRef
  • Cognitive assessment scale for stroke patients (CASP): A multicentric validation study
    Charles Benaim, Grégoire Wauquiez, Dominic Pérennou, Céline Piscicelli, Brigitte Lucas-Pineau, Huei-Yune Bonnin-Koang, Philippe Vuadens, Christine Binquet, Abderrahmane Bourredjem, Hervé Devilliers
    Annals of Physical and Rehabilitation Medicine.2022; 65(3): 101594.     CrossRef
  • Home-based portable fNIRS-derived cortical laterality correlates with impairment and function in chronic stroke
    Christopher Lee Friesen, Michael Lawrence, Tony Gerald Joseph Ingram, Shaun Gregory Boe
    Frontiers in Human Neuroscience.2022;[Epub]     CrossRef
  • 11,091 View
  • 113 Download
  • 7 Web of Science
  • 7 Crossref
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