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"Hyun Ju Chang"

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"Hyun Ju Chang"

Original Articles
Limb Differences in the Therapeutic Effects of Complex Decongestive Therapy on Edema, Quality of Life, and Satisfaction in Lymphedema Patients
Sujin Noh, Ji Hye Hwang, Tae Hee Yoon, Hyun Ju Chang, In Ho Chu, Jung Hyun Kim
Ann Rehabil Med 2015;39(3):347-359.   Published online June 30, 2015
DOI: https://doi.org/10.5535/arm.2015.39.3.347
Objective

To investigate the changing patterns of edema, quality of life (QOL), and patient-satisfaction after complex decongestive therapy (CDT) in three trajectories: arm lymphedema (AL), secondary leg lymphedema (LL) and primary leg lymphedema (PL).

Methods

Candidates for AL (n=35), LL (n=35) and PL (n=14) were identified from prospective databases. The patients were treated with CDT for 2 weeks, and lymphedema volume was measured before and immediately following the therapy. Patients then self-administered home therapy for 3 months and presented for a follow-up visit. The Korean version of Short Form-36 (SF-36) was used to assess QOL, and we administered a study-specific satisfaction survey.

Results

There was no significant difference in the volume reductions between the 3 groups. There were no significant differences in all of the measures between PL and LL. Overall initial QOL was significantly lower in patients with LL than in patients with AL. SF-36 scores post-CDT did not differ significantly between AL and LL. Clinically significant differences were noted between AL and LL in the mean values of the satisfaction survey.

Conclusion

AL, LL, and PL may have different longitudinal courses. We suggest that lower extremity lymphedema patients present more favorable outcomes after CDT with respect to QOL and satisfaction than upper extremity lymphedema patients. Clinicians should approach patients with different therapeutic considerations specific to each type or region of lymphedema before using CDT in clinical practice.

Citations

Citations to this article as recorded by  
  • The LYMPH trial: comparing microsurgical with conservative treatment for chronic breast cancer-associated lymphoedema – study protocol of a pragmatic randomised international multicentre superiority trial
    Elisabeth A Kappos, Yvonne Haas, Alexandra Schulz, Florian Peters, Shakuntala Savanthrapadian, Julia Stoffel, Maria C Katapodi, Rosine Mucklow, Benedict Kaiser, Alexander Haumer, Stephanie Etter, Marco Cattaneo, Daniel Staub, Karin Ribi, Jane Shaw, Trista
    BMJ Open.2025; 15(2): e090662.     CrossRef
  • Self-administered versus lymphedema therapist-administered complex decongestive therapy protocol in breast cancer-related lymphedema: a non-inferiority randomized controlled trial with three-month follow-up
    Sukriye Cansu Gultekin, Didem Karadibak, Ahmet Burak Cakir, Zeynep Gulsum Guc, Tugba Yavuzsen
    Breast Cancer Research and Treatment.2025; 212(1): 123.     CrossRef
  • Outcomes of complex decongestive therapy in managing upper limb lymphedema in female breast cancer patients at a palliative care unit of a tertiary care hospital in Bangladesh
    Rifat Jahan, A.K.M. Motiur Rahman Bhuiyan, Afroja Alam, Mostofa Kamal Chowdhury, Romena Hassan, Nisha Mortuja Aktar, Swaminathan Subramanian
    PLOS One.2025; 20(6): e0326040.     CrossRef
  • Lymphovenous Anastomosis and Vascularized Lymph Node Transfer Reduce Long-term Cellulitis Events in Patients With Secondary Lymphedema
    W. Nicholas Jungbauer, Santana Solomon, Erik M. Verhey, Jonathan L. Jeger, Yu-Hui Chang, Daniel H. Rhee, Alanna M. Rebecca, Michel Saint-Cyr, Edward M. Reece, William J. Casey
    Annals of Plastic Surgery.2025; 95(5): 522.     CrossRef
  • Effects of Inpatient Rehabilitation in Leg Lymphedema: A Naturalistic Prospective Cohort Study With Intra-individual Control of Effects
    Felix Angst, Thomas Benz, Susanne Lehmann, Peter S. Sándor, Stephan Wagner
    Archives of Physical Medicine and Rehabilitation.2023; 104(12): 2035.     CrossRef
  • Combined Complete Decongestive Therapy Reduces Volume and Improves Quality of Life and Functional Status in Patients With Breast Cancer-Related Lymphedema
    Pınar Borman, Ayşegül Yaman, Sina Yasrebi, Adeviye Pınar İnanlı, Ayşe Arıkan Dönmez
    Clinical Breast Cancer.2022; 22(3): e270.     CrossRef
  • May-Thurner Syndrome and Lymphedema Reconstruction
    Rohun Gupta, Emily Mathijs, Justin Hart, John Bates, Jeremy Powers, Kongkrit Chaiyasate
    Plastic and Reconstructive Surgery - Global Open.2022; 10(6): e4377.     CrossRef
  • Is the Effect of Complex Decongestive Therapy the Same for Primary and Secondary Lower Lymphedema?
    Hanife Abakay, Hanife Doğan, Havva Talay Çaliş, Türkan Akbayrak
    Lymphatic Research and Biology.2021; 19(2): 165.     CrossRef
  • Manual Lymphatic Drainage May Not Have an Additional Effect on the Intensive Phase of Breast Cancer-Related Lymphedema: A Randomized Controlled Trial
    Ekin Ilke Sen, Sina Arman, Mert Zure, Hadi Yavuz, Dilsad Sindel, Aydan Oral
    Lymphatic Research and Biology.2021; 19(2): 141.     CrossRef
  • Longitudinal impact of postmastectomy radiotherapy on arm lymphedema in patients with breast cancer: An analysis of serial changes in arm volume measured by infrared optoelectronic volumetry
    Nalee Kim, Haeyoung Kim, Ji Hye Hwang, Won Park, Won Kyung Cho, Seung Mi Yeo, Hyebin Lee, Sei Kyung Lee
    Radiotherapy and Oncology.2021; 158: 167.     CrossRef
  • Non-cancer-related lower limb lymphoedema in complex decongestive therapy: the patient experience
    Mary Costello, Zena Moore, Pinar Avsar, Linda Nugent, Tom O'Connor, Declan Patton
    Journal of Wound Care.2021; 30(3): 225.     CrossRef
  • Hemodynamic Responses in Lower Limb Lymphedema Patients Undergoing Physical Therapy
    Bianca Brix, Olivier White, Christian Ure, Gert Apich, Paul Simon, Andreas Roessler, Nandu Goswami
    Biology.2021; 10(7): 642.     CrossRef
  • The effects of complex decongestive therapy on kinesthetic sense of hands, upper extremity function, and quality of life in patients with breast cancer-related lymphedema
    Hilal Yeşil, Sibel Eyigör, Menekşe İnbat, Ferah Bulut
    Turkish Journal of Physical Medicine and Rehabilitation.2021; 67(2): 211.     CrossRef
  • Conservative treatment of lymphedema: the state of the art
    Anke Bergmann, Jaqueline Munaretto Timm Baiocchi, Mauro Figueiredo Carvalho de Andrade
    Jornal Vascular Brasileiro.2021;[Epub]     CrossRef
  • A compression device versus compression stockings in long-term therapy of lower limb primary lymphoedema after liposuction
    Marian Karafa, Anna Karafová, Andrzej Szuba
    Journal of Wound Care.2020; 29(1): 28.     CrossRef
  • Quality-of-Life Outcomes in Surgical vs Nonsurgical Treatment of Breast Cancer–Related Lymphedema
    Morgan L. Fish, Ritwik Grover, Graham S. Schwarz
    JAMA Surgery.2020; 155(6): 513.     CrossRef
  • Fluid Shifts Induced by Physical Therapy in Lower Limb Lymphedema Patients
    Bianca Brix, Gert Apich, Andreas Roessler, Christian Ure, Karin Schmid-Zalaudek, Helmut Hinghofer-Szalkay, Nandu Goswami
    Journal of Clinical Medicine.2020; 9(11): 3678.     CrossRef
  • Predictive value of lymphoscintigraphy in patients with breast cancer-related lymphedema undergoing complex decongestive therapy
    Young Hwan Kim, Ji Hye Hwang, Ji Hoon Bae, Joon Young Choi
    Breast Cancer Research and Treatment.2019; 173(3): 735.     CrossRef
  • Test of Responsiveness and Sensitivity of the Questionnaire “Lymphedema Quality of Life Inventory”
    Pia Klernäs, Aina Johnsson, John Boyages, Håkan Brorson, Alex Munnoch, Karin Johansson
    Lymphatic Research and Biology.2018; 16(3): 300.     CrossRef
  • SF-36 Shows Increased Quality of Life Following Complete Reduction of Postmastectomy Lymphedema with Liposuction
    Mattias Hoffner, Shirin Bagheri, Emma Hansson, Jonas Manjer, Thomas Troëng, Håkan Brorson
    Lymphatic Research and Biology.2017; 15(1): 87.     CrossRef
  • Quality of life in patients with primary and secondary lymphedema in the community
    Katharina Herberger, Christine Blome, Kristina Heyer, Franziska Ellis, Karl‐Christian Münter, Matthias Augustin
    Wound Repair and Regeneration.2017; 25(3): 466.     CrossRef
  • A Comparison of the Quality of Life in Patients With Primary and Secondary Lower Limb Lymphedema
    Deonni P. Stolldorf, Mary S. Dietrich, Sheila H. Ridner
    Western Journal of Nursing Research.2016; 38(10): 1313.     CrossRef
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Long-Term Effects of Complex Decongestive Therapy in Breast Cancer Patients With Arm Lymphedema After Axillary Dissection
Jung Min Hwang, Ji Hye Hwang, Tae Won Kim, Seung Yeol Lee, Hyun Ju Chang, In Ho Chu
Ann Rehabil Med 2013;37(5):690-697.   Published online October 29, 2013
DOI: https://doi.org/10.5535/arm.2013.37.5.690
Objective

To investigate the long-term effects of complex decongestive therapy (CDT) on edema reduction in breast cancer-related lymphedema patients after axillary dissection, according to the initial volume of edema.

Methods

A retrospective review of 57 patients with unilateral arm after an axillary dissection for breast cancer was performed. The patients, treated with two weeks of CDT and self-administered home therapy, were followed for 24 months. Arm volume was serially measured by using an optoelectronic volumeter prior to and immediately after CDT; and there were follow-up visits at 3, 6, 12, and 24 months. Patients were divided into two groups according to the percent excess volume (PEV) prior to CDT: group 1, PEV<20% and group 2, PEV≥20%.

Results

In group 1, mean PEV before CDT was 11.4±5.0% and 14.1±10.6% at 24 months after CDT with no significant difference. At the end of CDT, PEV was 28.8±15.7% in group 2, which was significantly lower than the baseline (41.9±19.6%). The reduction of PEV was maintained for 24 months in group 2.

Conclusion

The long-term effects of CDT were well-maintained for 24 months, but there was a difference in progression of PEV between the two groups. The patients with more initial PEV showed significant volume-reducing effects of CDT. In patients with less initial PEV, the severity of lymphedema did not progress to higher grades.

Citations

Citations to this article as recorded by  
  • Impact of Body Mass Index on the Outcomes of Intensive Complex Decongestive Therapy for Lower Limb Lymphedema
    Marie Warnier, Nina Antoniolli, Benoit Bihin, Jacqueline Frippiat, Chloé Meseeuw, Alexis Lheureux, Thierry Deltombe, Alberto Caggiati
    International Journal of Vascular Medicine.2026;[Epub]     CrossRef
  • Self-administered versus lymphedema therapist-administered complex decongestive therapy protocol in breast cancer-related lymphedema: a non-inferiority randomized controlled trial with three-month follow-up
    Sukriye Cansu Gultekin, Didem Karadibak, Ahmet Burak Cakir, Zeynep Gulsum Guc, Tugba Yavuzsen
    Breast Cancer Research and Treatment.2025; 212(1): 123.     CrossRef
  • Effects of 4-Week Complex Decongestive Therapy in the Management of Breast Cancer-Related Arm Lymphedema in Montenegrin Women Post-Mastectomy and Chemo/Radiotherapy
    Miloš Kuzmanović, Dušan Mustur
    Healthcare.2025; 13(20): 2596.     CrossRef
  • Early lymphaticovenous anastomosis in lymphedema management: a pilot study
    Fumio Onishi, Hayato Nagashima, Nanae Okuda, Toshiharu Minabe
    Plastic and Aesthetic Research.2024;[Epub]     CrossRef
  • Evidence for the clinical effectiveness of decongestive lymphoedema treatment for breast cancer–related arm lymphoedema, a systematic review
    Eunice Jeffs, Emma Ream, Cath Taylor, Arnie Purushotham, Debra Bick
    Supportive Care in Cancer.2024;[Epub]     CrossRef
  • Factors Predicting the Effect of a Complex Decongestive Therapy in Patients with Mild Lymphedema Following Mastectomy for Early Stage Breast Cancer
    Ju Hyeon Kim, Han Eum Choi, Jae Hyun Lee, Young-Joo Sim, Ho Joong Jeong, Ghi Chan Kim
    Lymphatic Research and Biology.2024; 22(5): 241.     CrossRef
  • Effectiveness of complete decongestive therapy for upper extremity breast cancer-related lymphedema: a review of systematic reviews
    Laura Gilchrist, Kim Levenhagen, Claire C. Davies, Linda Koehler
    Medical Oncology.2024;[Epub]     CrossRef
  • Effects of Complex Physical Therapy and Multimodal Approaches on Lymphedema Secondary to Breast Cancer: A Systematic Review and Meta-analysis of Randomized Controlled Trials
    Flávia Belavenuto Rangon, Jéssica da Silva, Almir Vieira Dibai-Filho, Rinaldo Roberto de Jesus Guirro, Elaine Caldeira de Oliveira Guirro
    Archives of Physical Medicine and Rehabilitation.2022; 103(2): 353.     CrossRef
  • Combined Complete Decongestive Therapy Reduces Volume and Improves Quality of Life and Functional Status in Patients With Breast Cancer-Related Lymphedema
    Pınar Borman, Ayşegül Yaman, Sina Yasrebi, Adeviye Pınar İnanlı, Ayşe Arıkan Dönmez
    Clinical Breast Cancer.2022; 22(3): e270.     CrossRef
  • Clinical use of photobiomodulation as a supportive care during radiation therapy
    Guillaume Klausner, Idriss Troussier, Charles-Henry Canova, René-Jean Bensadoun
    Supportive Care in Cancer.2022; 30(1): 13.     CrossRef
  • Lymphedema Index Ratio As Predictive Factor of Treatment in Patients with Breast Cancer-Related Lymphedema
    Han Eum Choi, Yeong Kyun Bae, Jae Hyun Lee, Ghi Chan Kim, Ho Joong Jeong, Young Joo Sim
    Lymphatic Research and Biology.2022; 20(3): 302.     CrossRef
  • Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022
    Jolien Robijns, Raj G. Nair, Joy Lodewijckx, Praveen Arany, Andrei Barasch, Jan M. Bjordal, Paolo Bossi, Anne Chilles, Patricia M. Corby, Joel B. Epstein, Sharon Elad, Reza Fekrazad, Eduardo Rodrigues Fregnani, Marie-Thérèse Genot, Ana M. C. Ibarra, Micha
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Long-Term Effects of Extracorporeal Shock Wave Therapy on Breast Cancer-Related Lymphedema
    Jong-Hwa Lee, Sang-Beom Kim, Kyeong-Woo Lee, Won-Wook Ha
    Journal of Clinical Medicine.2022; 11(22): 6747.     CrossRef
  • Manual Lymphatic Drainage May Not Have an Additional Effect on the Intensive Phase of Breast Cancer-Related Lymphedema: A Randomized Controlled Trial
    Ekin Ilke Sen, Sina Arman, Mert Zure, Hadi Yavuz, Dilsad Sindel, Aydan Oral
    Lymphatic Research and Biology.2021; 19(2): 141.     CrossRef
  • A comparison of the effectiveness of complex decongestive therapy and extracorporeal shock wave therapy in the treatment of lymphedema secondary to breast cancer
    Mehtap Aykac Cebicci, Meltem Dizdar
    Indian Journal of Surgery.2021; 83(3): 749.     CrossRef
  • Longitudinal impact of postmastectomy radiotherapy on arm lymphedema in patients with breast cancer: An analysis of serial changes in arm volume measured by infrared optoelectronic volumetry
    Nalee Kim, Haeyoung Kim, Ji Hye Hwang, Won Park, Won Kyung Cho, Seung Mi Yeo, Hyebin Lee, Sei Kyung Lee
    Radiotherapy and Oncology.2021; 158: 167.     CrossRef
  • État de l’art de la photobiomodulation dans la prise en charge des effets secondaires de la radiothérapie : indications et niveaux de preuve
    G. Klausner, R.J. Bensadoun, A. Champion, D. Benzaquen, C.H. Canova, A. Claren, V. Mancuso, J. Suhl, R. Balard, I. Troussier
    Cancer/Radiothérapie.2021; 25(6-7): 584.     CrossRef
  • Effects of Extracorporeal Shockwave Therapy on Improvements in Lymphedema, Quality of Life, and Fibrous Tissue in Breast Cancer-Related Lymphedema
    Kyeong Woo Lee, Sang Beom Kim, Jong Hwa Lee, Young Sam Kim
    Annals of Rehabilitation Medicine.2020; 44(5): 386.     CrossRef
  • Change of immune status parameters, clinical symptoms and health related quality of life patients with postmastectomy syndrome depending on the used rehabilitation complexes
    N.V. Agranovich, M.S. Sivolapova, A.A. Koychuev, O.V. Agranovich
    Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul'tury.2020; 97(6): 17.     CrossRef
  • Efficacy of self-administered complex decongestive therapy on breast cancer-related lymphedema: a single-blind randomized controlled trial
    M. B. Ligabue, I. Campanini, P. Veroni, A. Cepelli, M. Lusuardi, A. Merlo
    Breast Cancer Research and Treatment.2019; 175(1): 191.     CrossRef
  • Radial Nerve Injury Caused by Compression Garment for Lymphedema: A Case Report
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    PM&R.2019; 11(4): 436.     CrossRef
  • Clinical effectiveness of decongestive treatments on excess arm volume and patient-centered outcomes in women with early breast cancer-related arm lymphedema: a systematic review
    Eunice Jeffs, Emma Ream, Cath Taylor, Debra Bick
    JBI Database of Systematic Reviews and Implementation Reports.2018; 16(2): 453.     CrossRef
  • A Review of Treatment for Breast Cancer-Related Lymphedema
    Timothy D. Smile, Rahul Tendulkar, Graham Schwarz, Douglas Arthur, Stephen Grobmyer, Stephanie Valente, Frank Vicini, Chirag Shah
    American Journal of Clinical Oncology.2018; 41(2): 178.     CrossRef
  • An Auto-Adjustable Night Garment to Control Early Rebound Effect of Edema Volume After Intensive Phase of Decongestive Lymphedema Therapy
    Sandrine Mestre, Gessy Gaillard, Murielle Benhamou, Virginie Soulier-Sotto, Monira Nou, Marion Pasqualini, Cyrine Ben Amor, Isabelle Quere
    Lymphatic Research and Biology.2017; 15(4): 364.     CrossRef
  • Overview of cancer rehabilitation
    Ji Hye Hwang, Joon-Sung Kim
    Journal of the Korean Medical Association.2017; 60(8): 678.     CrossRef
  • What physiotherapeutic method for the treatment of post-mastectomy lymphedema is the most effective?
    T. I. Grushina
    Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul'tury.2017; 94(4): 59.     CrossRef
  • The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature
    Jolien Robijns, Sandrine Censabella, Paul Bulens, Annelies Maes, Jeroen Mebis
    Lasers in Medical Science.2017; 32(1): 229.     CrossRef
  • Extracorporeal Shock Wave Therapy for Breast Cancer–Related Lymphedema: A Pilot Study
    Mehtap Aykac Cebicci, Serap Tomruk Sutbeyaz, Sema Sezgin Goksu, Sehriban Hocaoglu, Arzu Oguz, Ayse Atilabey
    Archives of Physical Medicine and Rehabilitation.2016; 97(9): 1520.     CrossRef
  • Simplifying evidence-based management of breast cancer-related lymphedema
    Jane M. Armer, Joseph L. Feldman, Pamela L. Ostby, Kathryn M. Thrift, Bonnie B. Lasinski, Marcia S. Beck, Julia R. Rodrick, Steve Norton, Yuanlu Sun, Tipparat Udmuangpia, Nathan C. Armer, Bob R. Stewart
    Expert Review of Quality of Life in Cancer Care.2016; 1(5): 389.     CrossRef
  • Lymphedema Characteristics and the Efficacy of Complex Decongestive Physiotherapy in Malignant Lymphedema
    Su-Fen Liao
    American Journal of Hospice and Palliative Medicine®.2016; 33(7): 633.     CrossRef
  • Effect of complete decongestive therapy and home program on health- related quality of life in post mastectomy lymphedema patients
    Ganeswara Rao Melam, Syamala Buragadda, Adel A. Alhusaini, Nisha Arora
    BMC Women's Health.2016;[Epub]     CrossRef
  • Effect of low-level laser therapy on pain and swelling in women with breast cancer-related lymphedema: a systematic review and meta-analysis
    Betty Smoot, Laura Chiavola-Larson, Jeannette Lee, Hidelisa Manibusan, Diane D. Allen
    Journal of Cancer Survivorship.2015; 9(2): 287.     CrossRef
  • Validity of Quantitative Lymphoscintigraphy as a Lymphedema Assessment Tool for Patients With Breast Cancer
    Ji-Na Yoo, Youn-Soo Cheong, Yu-Sun Min, Sang-Woo Lee, Ho Yong Park, Tae-Du Jung
    Annals of Rehabilitation Medicine.2015; 39(6): 931.     CrossRef
  • Limb Differences in the Therapeutic Effects of Complex Decongestive Therapy on Edema, Quality of Life, and Satisfaction in Lymphedema Patients
    Sujin Noh, Ji Hye Hwang, Tae Hee Yoon, Hyun Ju Chang, In Ho Chu, Jung Hyun Kim
    Annals of Rehabilitation Medicine.2015; 39(3): 347.     CrossRef
  • Lymphoedema and health-related quality of life by early treatment in long-term survivors of breast cancer. A comparative retrospective study up to 15 years after diagnosis
    Katarina Y. Karlsson, Imke Wallenius, Lena B. Nilsson-Wikmar, Henrik Lindman, Birgitta B. K. Johansson
    Supportive Care in Cancer.2015; 23(10): 2965.     CrossRef
  • Putting Evidence Into Practice: Cancer-Related Lymphedema
    Mei R. Fu, Jie Deng, Jane M. Armer
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  • The effectiveness of decongestive treatments provided within 12 months of developing a swollen arm for women with breast cancer-related lymphedema: a systematic review protocol of quantitative evidence
    Eunice Jeffs, Debra Bick
    JBI Database of Systematic Reviews and Implementation Reports.2014; 12(11): 105.     CrossRef
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