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"Dae Yul Kim"

Original Articles
Immediate Effects of a Single Exercise on Behavior and Memory in the Early Period of Traumatic Brain Injury in Rats
Kyung Jae Yoon, Dae Yul Kim
Ann Rehabil Med 2018;42(5):643-651.   Published online October 31, 2018
DOI: https://doi.org/10.5535/arm.2018.42.5.643
Objective
To evaluate the immediate effect of single exercise on physical performance and memory in the early stage of traumatic brain injury (TBI) in rats.
Methods
Ninety TBI rats were randomly assigned to T0 (sedentary), T10 (treadmill 10 m/min for 30 minutes), or T20 (treadmill 20 m/min for 30 minutes) groups, on day 3 (D3), D7, and D14 after TBI, respectively. Rotarod (RR), Barnes maze (BM), brain magnetic resonance imaging (MRI) and MR spectroscopy were performed immediately before and 6 hours after exercise. Rats were sacrificed for immunohistochemistry with heat shock protein 70 (Hsp70) and glial fibrillary acidic protein (GFAP).
Results
On D3, the T10 and T20 groups demonstrated significant improvement in RR (p<0.05). On D7, only the T20 group showed significantly enhanced RR (p<0.05). In BM on D3, the T20 group showed significant deterioration compared with the other groups (p<0.05). Lesion volume did not significantly differ among the groups. MR spectroscopy on D3 showed that only the T20 group had significantly increased choline/creatine and 0.9/creatine (p<0.05). In the perilesional area on D3, only T20 had a significantly higher Hsp70 and GFAP than the T0 group. On D7, Hsp70 was significantly higher in the T20 group than in the T0 group (p<0.05). In the ipsilesional hippocampus on D3, the T20 group showed a significantly higher Hsp70 and GFAP than the T0 group (p<0.05).
Conclusion
A single session of low-intensity exercise in the early period of TBI improves behavioral performance without inducing cognitive deficits. However, high-intensity exercise can exacerbate cognitive function in the early period after TBI. Therefore, the optimal timing of rehabilitation and exercise intensity are crucial in behavior and memory recovery after TBI.

Citations

Citations to this article as recorded by  
  • The exercise and concussion health study (TECHS): Pilot and feasibility protocol
    Emma M. Tinney, Mark C. Nwakamma, Goretti España-Irla, Madeleine Perko, Ryan Luke Sodemann, Jacqueline Caefer, Julia Manczurowsky, Charles H. Hillman, Alexandra Stillman, Timothy P. Morris
    Contemporary Clinical Trials Communications.2026; 49: 101608.     CrossRef
  • Randomized Controlled Trial: Preliminary Investigation of the Impact of High-Intensity Treadmill Gait Training on Recovery Among Persons with Traumatic Brain Injury
    Tyler Shick, Courtney Perkins, Arco Paul, Melissa Martinez, Joseph Joyce, Katy Beach, Jeffrey Swahlan, Justin Weppner
    Neurotrauma Reports.2025; 6(1): 82.     CrossRef
  • Optimal Timing of Exercise for Enhanced Learning and Memory: Insights From CA1 and CA3 Regions in Traumatic Brain Injury Model in Male Rats
    Forouzan Rafie, Sedigheh Amiresmaili, Mohammad Amin Rajizadeh, Mohammad Pourranjbar, Elham Jafari, Mohammad Khaksari, Sara Shirazpour, Omid Moradnejad, Amir Hossein Nekouei
    Brain and Behavior.2025;[Epub]     CrossRef
  • Maternal Treadmill Exercise and Zinc Supplementation Alleviate Prenatal Stress–Induced Cognitive Deficits and Restore Neurological Biomarkers in Offspring: A Study on Male Rats Aged 30 and 90 Days
    Sina Fatehfar, Parsa Sameei, Naseh Abdollahzade, Leila Chodari, Ehsan Saboory, Shiva Roshan‐Milani
    Developmental Neurobiology.2025;[Epub]     CrossRef
  • Protective effects of early exercise on neuroinflammation, and neurotoxicity associated by traumatic brain injury: a behavioral and neurochemical approach
    Forouzan Rafie, Mohammad Khaksari, Sedigheh Amiresmaili, Zahra Soltani, Mohammad Pourranjbar, Sara Shirazpour, Elham Jafari
    International Journal of Neuroscience.2024; 134(7): 700.     CrossRef
  • Effect of stress on the rehabilitation performance of rats with repetitive mild fluid percussion-induced traumatic brain injuries
    Yu-Lin Wang, Chi-Chun Chen, Ching-Ping Chang
    Cognitive Neurodynamics.2024; 18(1): 283.     CrossRef
  • Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery
    Amery Treble-Barna, Bailey A. Petersen, Zachary Stec, Yvette P. Conley, Ericka L. Fink, Patrick M. Kochanek
    Biomolecules.2024; 14(2): 191.     CrossRef
  • Treating Traumatic Brain Injury with Exercise: Onset Delay and Previous Training as Key Factors Determining its Efficacy
    Tanit Sánchez-Martín, David Costa-Miserachs, Margalida Coll-Andreu, Isabel Portell-Cortés, Soleil García-Brito, Meritxell Torras-Garcia
    Neurorehabilitation and Neural Repair.2024; 38(10): 715.     CrossRef
  • Physical exercise as a cognitive rehabilitation treatment after traumatic brain injury: Intensity- and sex-dependent effects
    Ángel Gómez-Porcuna, Meritxell Torras-Garcia, Margalida Coll-Andreu, Soleil García-Brito, David Costa-Miserachs
    Experimental Neurology.2024; 381: 114941.     CrossRef
  • Alterações na memória e no cortisol após única sessão de exercício resistido
    Afonso Denofre De Carvalho, Augusto Mattos Spinato, Bárbara França Kanadani, Beatriz Colombo Molina, Cecília de Souza Menezes Trindade, Marcos Alexandre Malheiros Sales, Juliana Cintra, Alex Moreira Souza
    Cuadernos de Educación y Desarrollo.2023; 15(12): 16423.     CrossRef
  • The benefits of exercise for outcome improvement following traumatic brain injury: Evidence, pitfalls and future perspectives
    Yulan Zhang, Zhihai Huang, Honglin Xia, Jing Xiong, Xu Ma, Chengyi Liu
    Experimental Neurology.2022; 349: 113958.     CrossRef
  • The effects of early exercise in traumatic brain-injured rats with changes in motor ability, brain tissue, and biomarkers
    Chung Kwon Kim, Jee Soo Park, Eunji Kim, Min-Kyun Oh, Yong-Taek Lee, Kyung Jae Yoon, Kyeung Min Joo, Kyunghoon Lee, Young Sook Park
    BMB Reports.2022; 55(10): 512.     CrossRef
  • Involuntary, forced or voluntary exercise can ameliorate the cognitive deficits by enhancing levels of hippocampal NMDAR1, pAMPAR1 and pCaMKII in a model of vascular dementia
    Yangyang Lin, Yangfan Xu, Huiting Feng, Longfei You, Juntao Dong, Zunlin Gao, Suiying Peng, Yujie Deng, Peihui Wu
    Neurological Research.2021; 43(5): 349.     CrossRef
  • Swimming exercise improves short‐ and long‐term memories: Time‐course changes
    Mahmoud A. Alomari, Karem H. Alzoubi, Omar F. Khabour
    Physiological Reports.2021;[Epub]     CrossRef
  • The Effect of Aerobic Exercise on Concussion Recovery: A Pilot Clinical Trial
    Aliyah R. Snyder, Sarah M. Greif, James R. Clugston, David B. FitzGerald, Joshua F. Yarrow, Talin Babikian, Christopher C. Giza, Floyd J. Thompson, Russell M. Bauer
    Journal of the International Neuropsychological Society.2021; 27(8): 790.     CrossRef
  • Aggravating effects of treadmill exercises during the early-onset period in a rat traumatic brain injury model: When should rehabilitation exercises be initiated?
    Satoru Taguchi, Mohammed E. Choudhury, Kazuya Miyanishi, Yuiko Nakanishi, Kenji Kameda, Naoki Abe, Hajime Yano, Toshihiro Yorozuya, Junya Tanaka
    IBRO Reports.2019; 7: 82.     CrossRef
  • 8,725 View
  • 182 Download
  • 15 Web of Science
  • 16 Crossref
Prediction of Functional Outcome in Axonal Guillain-Barre Syndrome
Eun Jung Sung, Dae Yul Kim, Min Cheol Chang, Eun Jae Ko
Ann Rehabil Med 2016;40(3):481-488.   Published online June 29, 2016
DOI: https://doi.org/10.5535/arm.2016.40.3.481
Objective

To identify the factors that could predict the functional outcome in patients with the axonal type of Guillain-Barre syndrome (GBS).

Methods

Two hundred and two GBS patients admitted to our university hospital between 2003 and 2014 were reviewed retrospectively. We defined a good outcome as being "able to walk independently at 1 month after onset" and a poor outcome as being "unable to walk independently at 1 month after onset". We evaluated the factors that differed between the good and poor outcome groups.

Results

Twenty-four patients were classified into the acute motor axonal neuropathy type. There was a statistically significant difference between the good and poor outcome groups in terms of the GBS disability score at admission, and GBS disability score and Medical Research Council sum score at 1 month after admission. In an electrophysiologic analysis, the good outcome group showed greater amplitude of median, ulnar, deep peroneal, and posterior tibial nerve compound muscle action potentials (CMAP) and greater amplitude of median, ulnar, and superficial peroneal sensory nerve action potentials (SNAP) than the poor outcome group.

Conclusion

A lower GBS disability score at admission, high amplitude of median, ulnar, deep peroneal, and posterior tibial CMAPs, and high amplitude of median, ulnar, and superficial peroneal SNAPs were associated with being able to walk at 1 month in patients with axonal GBS.

Citations

Citations to this article as recorded by  
  • Patient Outcomes Among Medicare Beneficiaries With Guillain–Barré Syndrome
    Brad Wright, Samantha R. Eiffert, Abagail Cirincione, Joshua Nardin, James F. Howard, Rebecca E. Traub
    Journal of the Peripheral Nervous System.2026;[Epub]     CrossRef
  • Association between tuberculosis and Guillain–Barré syndrome: a systematic review
    Chowdhury Adnan Sami, Refaya Tasnim, Husna Rafsana, Joydip Chowdhury, Samiha Jabin Susmita, Anika Tabassum, Mohammad Ferdous Ur Rahaman, Shohael Mahmud Arafat
    Brain Disorders.2026; 21: 100299.     CrossRef
  • Potential advantage of therapeutic plasma exchange over intravenous immunoglobulin in children with axonal variant of Guillain-Barré syndrome: A report of six paediatric cases
    Joyisa Deb, Gita Negi, Aswin K. Mohan, Indar Kumar Sharawat, Pradip Banerjee, Deepali Chauhan, Daljit Kaur, Ashish Jain
    Transfusion Clinique et Biologique.2025; 32(1): 112.     CrossRef
  • Acute motor axonal neuropathy: features of diagnosis, treatment and rehabilitation
    V. B. Voitenkov, I. G. Samojlova, E. Yu. Skripchenko, I. V. Cherkashina, A. V. Klimkin, M. A. Irikova, P. S. Verbenko
    Russian neurological journal.2025; 29(6): 20.     CrossRef
  • Neuroprognostication: Guillain–Barré Syndrome
    Rebecca Traub, Vinay Chaudhry
    Seminars in Neurology.2023; 43(05): 791.     CrossRef
  • Relation between Guillain-Barré syndrome and Covid-19: Case-Series
    Merey Bakytzhanovna Jumagaliyeva, Dinmukhamed Nurniyazovich Ayaganov, Ibrahim Anwar Abdelazim, Samat Sagatovich Saparbayev, Nodira Miratalievna Tuychibaeva, Yergen Jumashevich Kurmambayev
    Journal of Medicine and Life.2023; 16(9): 1433.     CrossRef
  • Clinical and Electrophysiological Factors Predicting Prolonged Recovery in Children with Guillain–Barré Syndrome
    Ekta Agarwal, Ankita Bhagat, Kavita Srivastava, Bina Thakore, Sujit Jagtap, Umesh Kalane, Surekha Rajadhyaksha
    Indian Journal of Pediatrics.2022; 89(5): 452.     CrossRef
  • Erasmus Guillain-Barre Syndrome Outcome Score (EGOS) to predict functional outcomes
    Maria Ulfa, Titis Widowati, Agung Triono
    Paediatrica Indonesiana.2022; 62(2): 130.     CrossRef
  • Acute Motor Sensory Axonal Neuropathy: A Variant of Guillain–Barré Syndrome—A Rare Case Report
    Gurinder Mohan, Richa G Thaman, Sanjeev K Saggar
    AMEI's Current Trends in Diagnosis & Treatment.2021; 4(2): 110.     CrossRef
  • COVID-19-Associated Guillain-Barre Syndrome: Atypical Para-infectious Profile, Symptom Overlap, and Increased Risk of Severe Neurological Complications
    Mayanja M. Kajumba, Brad J. Kolls, Deborah C. Koltai, Mark Kaddumukasa, Martin Kaddumukasa, Daniel T. Laskowitz
    SN Comprehensive Clinical Medicine.2020; 2(12): 2702.     CrossRef
  • Treatment of an acute motor and sensory axonal neuropathy with propionate in a 33-year-old male
    Min-Suk Yoon, Kalliopi Pitarokoili, Dietrich Sturm, Aiden Haghikia, Ralf Gold, Anna Lena Fisse
    Therapeutic Advances in Neurological Disorders.2018;[Epub]     CrossRef
  • 11,910 View
  • 155 Download
  • 6 Web of Science
  • 11 Crossref
The Effect of Transcranial Direct Current Stimulation on Neglect Syndrome in Stroke Patients
You Gyoung Yi, Min Ho Chun, Kyung Hee Do, Eun Jung Sung, Yong Gyu Kwon, Dae Yul Kim
Ann Rehabil Med 2016;40(2):223-229.   Published online April 25, 2016
DOI: https://doi.org/10.5535/arm.2016.40.2.223
Objective

To examine whether transcranial direct current stimulation (tDCS) applied over the posterior parietal cortex (PPC) improves visuospatial attention in stroke patients with left visuospatial neglect.

Methods

Patients were randomly assigned to 1 of 3 treatment groups: anodal tDCS over the right PPC, cathodal tDCS over the left PPC, or sham tDCS. Each patient underwent 15 sessions of tDCS (5 sessions per week for 3 weeks; 2 mA for 30 minutes in each session). Outcome measures were assessed before treatment and 1 week after completing the treatment.

Results

From pre- to post-treatment, there was an improvement in the motor-free visual perception test (MVPT), line bisection test (LBT), star cancellation test (SCT), Catherine Bergego Scale (CBS), Korean version of Modified Barthel Index (K-MBI), and Functional Ambulation Classification in all 3 groups. Improvements in the MVPT, SCT, and LBT were greater in the anodal and cathodal groups than in the sham group. However, improvements in other outcomes were not significantly different between the 3 groups, although there was a tendency for improved CBS or K-MBI scores in the anodal and cathodal groups, as compared with the sham group.

Conclusion

The study results indicated that the facilitatory effect of anodal tDCS applied over the right PPC, and the inhibitory effect of cathodal tDCS applied over the left PPC, improved symptoms of visuospatial neglect. Thus, tDCS could be a successful adjuvant therapeutic modality to recover neglect symptom, but this recovery might not lead to improvements in activities of daily living function and gait function.

Citations

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    Auwal Abdullahi, Thomson W. L. Wong, Shamay S. M. Ng
    Sensory Neuroscience.2025;[Epub]     CrossRef
  • European Stroke Organisation (ESO) guideline on visual impairment in stroke
    Fiona J Rowe, Lauren R Hepworth, María Begoña Coco-Martin, Celine R Gillebert, Luis Leal-Vega, Anja Palmowski-Wolfe, Eleni Papageorgiou, Stephen James Ryan, Karolina Skorkovska, Anne Hege Aamodt
    European Stroke Journal.2025; 10(4): 1087.     CrossRef
  • Non-invasive brain stimulation to improve visual perception after stroke: a systematic review and meta-analysis
    Luis Leal-Vega, Adrián Martín-Gutiérrez, Antonio Dueñas-Laita, Marta Ruiz-Mambrilla, León Morales-Quezada, David García-Azorín, María Begoña Coco-Martín, Juan Francisco Arenillas-Lara
    Topics in Stroke Rehabilitation.2025; : 1.     CrossRef
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    Liya Zhang, Liang Zhou, Qing Ye, Li Zhang, Yurou Kong, Siying Xia
    Neurological Sciences.2024; 45(4): 1581.     CrossRef
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    Mengyu Yan, Jiarui Liu, Yiming Guo, Qingtao Hou, Jiaqi Song, Xiaoqin Wang, Weihua Yu, Yang Lü
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    Brain Sciences.2024; 14(6): 614.     CrossRef
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    Haim Raviv, Nira Mashal, Orna Peleg
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    Physical and rehabilitation medicine, medical rehabilitation.2023; 5(3): 237.     CrossRef
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    Annals of Physical and Rehabilitation Medicine.2021; 64(2): 101393.     CrossRef
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    Experimental Brain Research.2021; 239(2): 613.     CrossRef
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  • Visuospatial Neglect - a Theory-Informed Overview of Current and Emerging Strategies and a Systematic Review on the Therapeutic Use of Non-invasive Brain Stimulation
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  • Motor cortex Transcranial Direct Current Stimulation (tDCS) improves acute stroke visuo-spatial neglect: A series of four case reports
    S. Bornheim, P. Maquet, J.L. Croisier, J.M. Crielaard, J.F. Kaux
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  • Noninvasive Brain Stimulation Improves Hemispatial Neglect After Stroke: A Systematic Review and Meta-Analysis
    Ana Paula S. Salazar, Patrícia G. Vaz, Ritchele R. Marchese, Cinara Stein, Camila Pinto, Aline S. Pagnussat
    Archives of Physical Medicine and Rehabilitation.2018; 99(2): 355.     CrossRef
  • Efficacy of Noninvasive Brain Stimulation on Unilateral Neglect After Stroke
    Jingjing Fan, Yi Li, Yonghong Yang, Yun Qu, Shasha Li
    American Journal of Physical Medicine & Rehabilitation.2018; 97(4): 261.     CrossRef
  • Clinical Practice Guideline for Stroke Rehabilitation in Korea 2016
    Deog Young Kim, Yun-Hee Kim, Jongmin Lee, Won Hyuk Chang, Min-Wook Kim, Sung-Bom Pyun, Woo-Kyoung Yoo, Suk Hoon Ohn, Ki Deok Park, Byung-Mo Oh, Seong Hoon Lim, Kang Jae Jung, Byung-Ju Ryu, Sun Im, Sung Ju Jee, Han Gil Seo, Ueon Woo Rah, Joo Hyun Park, Min
    Brain & Neurorehabilitation.2017;[Epub]     CrossRef
  • Transcranial Electrical Stimulation as a Tool to Enhance Attention
    L. C. Reteig, L. J. Talsma, M. R. van Schouwenburg, H. A. Slagter
    Journal of Cognitive Enhancement.2017; 1(1): 10.     CrossRef
  • Transcranial Direct Current Stimulation in Post-stroke Chronic Aphasia: The Impact of Baseline Severity and Task Specificity in a Pilot Sample
    Catherine Norise, Daniela Sacchetti, Roy Hamilton
    Frontiers in Human Neuroscience.2017;[Epub]     CrossRef
  • Neuro-ophthalmic manifestations of cerebrovascular accidents
    Alaa S. Bou Ghannam, Prem S. Subramanian
    Current Opinion in Ophthalmology.2017; 28(6): 564.     CrossRef
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    Jean-Pascal Lefaucheur
    Neurophysiologie Clinique/Clinical Neurophysiology.2016; 46(6): 319.     CrossRef
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The Additive Effects of Core Muscle Strengthening and Trunk NMES on Trunk Balance in Stroke Patients
Eun Jae Ko, Min Ho Chun, Dae Yul Kim, Jin Hwa Yi, Won Kim, Jayoung Hong
Ann Rehabil Med 2016;40(1):142-151.   Published online February 26, 2016
DOI: https://doi.org/10.5535/arm.2016.40.1.142
Objective

To investigate an additive effect of core muscle strengthening (CMS) and trunk neuromuscular electrical stimulation (tNEMS) on trunk balance in stroke patients.

Methods

Thirty patients with acute or subacute stroke who were unable to maintain static sitting balance for >5 minutes were enrolled and randomly assigned to 3 groups, i.e., patients in the CMS (n=10) group received additional CMS program; the tNMES group (n=10) received additional tNMES over the posterior back muscles; and the combination (CMS and tNMES) group (n=10) received both treatments. Each additional treatment was performed 3 times per week for 20 minutes per day over 3 weeks. Korean version of Berg Balance Scale (K-BBS), total score of postural assessment scale for stroke patients (PASS), Trunk Impairment Scale (TIS), and Korean version of Modified Barthel Index (K-MBI) were evaluated before and after 3 weeks of therapeutic intervention.

Results

All 3 groups showed improvements in K-BBS, PASS, TIS, and K-MBI after therapeutic interventions, with some differences. The combination group showed more improvements in K-BBS and the dynamic sitting balance of TIS, as compared to the CMS group; and more improvement in K-BBS, as compared to the tNMES group.

Conclusion

The results indicated an additive effect of CMS and tNMES on the recovery of trunk balance in patients with acute or subacute stroke who have poor sitting balance. Simultaneous application of CMS and tNMES should be considered when designing a rehabilitation program to improve trunk balance in stroke patients.

Citations

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