Objective
To assess the altered pattern of intracortical excitability of the affected and unaffected hemispheres in stroke patients using paired-pulse transcranial magnetic stimulation (TMS).
Methods
We evaluated intracortical inhibition (ICI) and intracortical facilitation (ICF) in both hemispheres at acute and subacute stages of 103 stroke patients using paired-pulse TMS. The patients were divided into two groups: mild-to-moderate patients whose motor evoked potential (MEP) was recorded in the affected hemisphere; and severe patients whose MEP was not recorded in the affected hemisphere.
Results
In mild-to-moderate patients, the value of ICI in the affected hemisphere was increased from 70.3% to 77.9% and the value of ICI in the unaffected hemisphere was decreased from 74.8% to 70.3% with eventual progression in acute to subacute stages of stroke. In severe patients, the value of ICI in the unaffected hemisphere was increased from 65.4% to 75.6%. The changes in ICF were not significantly different in this study.
Conclusion
We conclude that the unaffected hemisphere was more disinhibited than the affected hemisphere in acute phase of mild-to-moderate stroke, and the affected hemisphere was more disinhibited in the subacute stage. The unaffected hemisphere was inhibited in severe cases in acute-to-subacute phases of stroke. This finding facilitates appropriate neuromodulation of acute-to-subacute phases in mild-to-severe stroke patients.

Citations

• Primed low frequency repetitive transcranial magnetic stimulation rebalances cortical excitatory-inhibitory circuitry and improves functional outcomes in infantile cerebral palsy patients: A randomized controlled trial
  Aliya Mufti, Suman Jain, Kanwal Preet Kochhar, Sheffali Gulati, Sanjay Wadhwa, Kapil Sikka, Rohit Saxena, Md Iqbal Alam
  Journal of Neurorestoratology.2025; 13(1): 100169.     CrossRef
• Altered Corticospinal and Intracortical Excitability After Stroke: A Systematic Review With Meta-Analysis
  Edward P. Washabaugh, Sierra A. Foley, Emily G. Czopek, Chandramouli Krishnan
  Neurorehabilitation and Neural Repair.2024; 38(11-12): 845.     CrossRef
• Corticomotor excitability is altered in central neuropathic pain compared with non-neuropathic pain or pain-free patients
  Luciana Mendonça Barbosa, Fernanda Valerio, Valquíria Aparecida da Silva, Antônia Lilian de Lima Rodrigues, Ricardo Galhardoni, Lin Tchia Yeng, Jefferson Rosi Junior, Adriana Bastos Conforto, Leandro Tavares Lucato, Manoel Jacobsen Teixeira, Daniel Ciampi
  Neurophysiologie Clinique.2023; 53(3): 102845.     CrossRef
• Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?
  Mahmut Martin Yüksel, Shiqi Sun, Charles Latchoumane, Jocelyne Bloch, Gregoire Courtine, Estelle Emeline Raffin, Friedhelm Christoph Hummel
  IEEE Open Journal of Engineering in Medicine and Biology.2023; 4: 300.     CrossRef
• Central Post-Stroke Pain: An Integrative Review of Somatotopic Damage, Clinical Symptoms, and Neurophysiological Measures
  Daniel Fernando Arias Betancur, Maria da Graça Lopes Tarragó, Iraci Lucena da Silva Torres, Felipe Fregni, Wolnei Caumo
  Frontiers in Neurology.2021;[Epub]     CrossRef
• Motor excitability in bilateral moyamoya vasculopathy and the impact of revascularization
  Gueliz Acker, Davide Giampiccolo, Kerstin Rubarth, Robert Mertens, Anna Zdunczyk, Juliane Hardt, Daniel Jussen, Heike Schneider, Tizian Rosenstock, Vera Mueller, Thomas Picht, Peter Vajkoczy
  Neurosurgical Focus.2021; 51(3): E7.     CrossRef
• Nabiximols plus robotic assisted gait training in improving motor performances in people with Multiple Sclerosis.
  Rocco Salvatore Calabrò, Margherita Russo, Antonino Naro, Rossella Ciurleo, Giangaetano D'Aleo, Carmela Rifici, Tina Balletta, Cristian La Via, Massimo Destro, Placido Bramanti, Edoardo Sessa
  Multiple Sclerosis and Related Disorders.2020; 43: 102177.     CrossRef
• The balance recovery bimodal model in stroke patients between evidence and speculation: Do recent studies support it?
  Giovanni Di Pino, Vincenzo Di Lazzaro
  Clinical Neurophysiology.2020; 131(10): 2488.     CrossRef
• Promotion of Poststroke Motor-Function Recovery with Repetitive Transcranial Magnetic Stimulation by Regulating the Interhemispheric Imbalance
  Xiaoxia Yuan, Yuan Yang, Na Cao, Changhao Jiang
  Brain Sciences.2020; 10(9): 648.     CrossRef
• Does hand robotic rehabilitation improve motor function by rebalancing interhemispheric connectivity after chronic stroke? Encouraging data from a randomised-clinical-trial
  Rocco Salvatore Calabrò, Maria Accorinti, Bruno Porcari, Luigi Carioti, Laura Ciatto, Luana Billeri, Veronica Agata Andronaco, Franco Galletti, Serena Filoni, Antonino Naro
  Clinical Neurophysiology.2019; 130(5): 767.     CrossRef
• Association of Lesion Location With Long-Term Recovery in Post-stroke Aphasia and Language Deficits
  Bomi Sul, Kyoung Bo Lee, Bo Young Hong, Joon Sung Kim, Jaewon Kim, Woo Seop Hwang, Seong Hoon Lim
  Frontiers in Neurology.2019;[Epub]     CrossRef

Objective
To evaluate the effects of electric cortical stimulation (ECS) and transcranial direct current stimulation (tDCS) on motor and cognitive function recovery and brain plasticity in focal traumatic brain injury (TBI) of rats model.
Methods
Forty rats were pre-trained to perform a single pellet reaching task (SPRT), rotarod test (RRT), and Y-maze test for 14 days, then a focal TBI was induced by a weight drop model on the motor cortex. All rats were randomly assigned to one of the three groups: anodal ECS (50 Hz and 194 μs) (ECS group), tDCS (0.1 mA, 50 Hz and 200 μs) (tDCS group), and no stimulation as a control group. Four-week stimulation, including rehabilitation, was started 3 days after the operation. SPRT, RRT, and Y-maze were measured from day 1 to day 28 after the TBI was induced. Histopathological and immunohistochemistry staining evaluations were performed at 4 weeks.
Results
SPRT was improved from day 7 to day 26 in ECS, and from day 8 to day 26 in tDCS compared to the control group (p<0.05). SPRT of ECS group was significantly improved on days 3, 8, 9, and 17 compared to the tDCS group. Y-maze was improved from day 8 to day 16 in ECS, and on days 6, 12, and 16 in the tDCS group compared to the control group (p<0.05). Y-maze of the ECS group was significantly improved on day 9 to day 15 compared to the tDCS group. The c-Fos protein expression was better in the ECS group and the tDCS group compared to the control group.
Conclusion
Electric stimulation in rats modified with a focal TBI is effective for motor recovery and brain plasticity. ECS induced faster behavioral and cognitive improvements compared to tDCS during the recovery period of rats with a focal TBI.

Citations

• Neurophysiological Markers of Reward Processing Can Inform Preclinical Neurorehabilitation Approaches for Cognitive Impairments Following Brain Injury
  Miranda Francoeur Koloski, Reyana Menon, Victoria Krasnyanskiy
  Brain Sciences.2025; 15(5): 471.     CrossRef
• Exploring the Intersection of Brain–Computer Interfaces and Quantum Sensing: A Review of Research Progress and Future Trends
  Kun Liao, Zhaochu Yang, Dong Tao, Libo Zhao, Nuno Pires, Carlos Alberto Dorao, Bjørn Torger Stokke, Lars Eric Roseng, Wen Liu, Zhuangde Jiang
  Advanced Quantum Technologies.2024;[Epub]     CrossRef
• Advances in Neurorehabilitation: Strategies and Outcomes for Traumatic Brain Injury Recovery
  Purvi Kaurani, Ana Vitoria Moreira de Marchi Apolaro, Keerthi Kunchala, Shriya Maini, Huda A F Rges, Ashley Isaac, Mohit Lakkimsetti, Mohammed Raake, Zahra Nazir
  Cureus.2024;[Epub]     CrossRef
• Neuromodulation Therapies in Pre-Clinical Models of Traumatic Brain Injury: Systematic Review and Translational Applications
  Shanan Surendrakumar, Thallita Kelly Rabelo, Ana Carolina P. Campos, Adriano Mollica, Agessandro Abrahao, Nir Lipsman, Matthew J. Burke, Clement Hamani
  Journal of Neurotrauma.2023; 40(5-6): 435.     CrossRef
• Effects of single session transcranial direct current stimulation on aerobic performance and one arm pull-down explosive force of professional rock climbers
  Jia Luo, Caihua Fang, Sen Huang, Jinlong Wu, Bowen Liu, Jingxuan Yu, Wen Xiao, Zhanbing Ren
  Frontiers in Physiology.2023;[Epub]     CrossRef
• Electrical stimulation methods and protocols for the treatment of traumatic brain injury: a critical review of preclinical research
  D. Ziesel, M. Nowakowska, S. Scheruebel, K. Kornmueller, U. Schäfer, R. Schindl, C. Baumgartner, M. Üçal, T. Rienmüller
  Journal of NeuroEngineering and Rehabilitation.2023;[Epub]     CrossRef
• Therapeutic effects of transcranial direct current stimulation on loss of motor function caused by experimental mild traumatic brain injury
  Güven AKÇAY, Recep BAYDEMİR
  Cukurova Medical Journal.2023; 48(3): 972.     CrossRef
• Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects
  Yuwen Sun, Manrui Li, Shuqiang Cao, Yang Xu, Peiyan Wu, Shuting Xu, Qian Pan, Yadong Guo, Yi Ye, Zheng Wang, Hao Dai, Xiaoqi Xie, Xiameng Chen, Weibo Liang
  International Journal of Molecular Sciences.2022; 23(3): 1800.     CrossRef
• Using dual polarities of transcranial direct current stimulation in global cerebral ischemia and its following reperfusion period attenuates neuronal injury
  Rasoul Kaviannejad, Seyed Morteza Karimian, Esmail Riahi, Ghorbangol Ashabi
  Metabolic Brain Disease.2022; 37(5): 1503.     CrossRef
• Preliminary Study on Safety Assessment of 10 Hz Transcranial Alternating Current Stimulation in Rat Brain
  Sung Suk Oh, Yoon Bum Lee, Jae Sun Jeon, Sang-Hyun An, Jong-ryul Choi
  Applied Sciences.2022; 12(11): 5299.     CrossRef
• Short-Term Cortical Electrical Stimulation during the Acute Stage of Traumatic Brain Injury Improves Functional Recovery
  Liang-Chao Wang, Wei-Yen Wei, Pei-Chuan Ho
  Biomedicines.2022; 10(8): 1965.     CrossRef
• Neurostimulation for Functional Recovery After Traumatic Brain Injury: Current Evidence and Future Directions for Invasive Surgical Approaches
  Jakov Tiefenbach, Hugh H. Chan, Andre G. Machado, Kenneth B. Baker
  Neurosurgery.2022; 91(6): 823.     CrossRef
• Cortical Electrical Stimulation Ameliorates Traumatic Brain Injury-Induced Sensorimotor and Cognitive Deficits in Rats
  Chi-Wei Kuo, Ming-Yuan Chang, Hui-Hua Liu, Xiao-Kuo He, Shu-Yen Chan, Ying-Zu Huang, Chih-Wei Peng, Pi-Kai Chang, Chien-Yuan Pan, Tsung-Hsun Hsieh
  Frontiers in Neural Circuits.2021;[Epub]     CrossRef
• Rodent models used in preclinical studies of deep brain stimulation to rescue memory deficits
  Matthieu Faillot, Antoine Chaillet, Stéphane Palfi, Suhan Senova
  Neuroscience & Biobehavioral Reviews.2021; 130: 410.     CrossRef
• Optogenetic Modulation for the Treatment of Traumatic Brain Injury
  Samantha L. Delaney, Julian L. Gendreau, Marissa D'Souza, Austin Y. Feng, Allen L. Ho
  Stem Cells and Development.2020; 29(4): 187.     CrossRef
• Cathodal Transcranial Direct-Current Stimulation Selectively Decreases Impulsivity after Traumatic Brain Injury in Rats
  Kris M. Martens, Kristen M. Pechacek, Cassandra G. Modrak, Virginia J. Milleson, Binxing Zhu, Cole Vonder Haar
  Journal of Neurotrauma.2019; 36(19): 2827.     CrossRef
• Enhancing rehabilitation and functional recovery after brain and spinal cord trauma with electrical neuromodulation
  Anna-Sophie Hofer, Martin E. Schwab
  Current Opinion in Neurology.2019; 32(6): 828.     CrossRef
• Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes
  Edgard Morya, Kátia Monte-Silva, Marom Bikson, Zeinab Esmaeilpour, Claudinei Eduardo Biazoli, Andre Fonseca, Tommaso Bocci, Faranak Farzan, Raaj Chatterjee, Jeffrey M. Hausdorff, Daniel Gomes da Silva Machado, André Russowsky Brunoni, Eva Mezger, Luciane
  Journal of NeuroEngineering and Rehabilitation.2019;[Epub]     CrossRef

Objective
To investigate the dose-related effect of trunk control training (TCT) using Trunk Stability Rehabilitation Robot Balance Trainer (TSRRBT) in chronic stroke patients with poor sitting balance.
Methods
This was a retrospective study of 38 chronic stroke patients with poor sitting balance that underwent TCT with TSRRBT. The participants were assigned either to the low-dose training (LDT) group (n=18) or to the highdose training (HDT) group (n=20). In addition to the conventional rehabilitation therapy, the LDT group received 5 sessions of TSRRBT intervention per week, whereas the HDT group received 10 sessions of TSRRBT intervention per week. The outcome measures were the scores on the Trunk Impairment Scale (TIS) and its subscales, Berg Balance Scale (BBS), Functional Ambulation Classification (FAC), and the Korean version of Modified Barthel Index (K-MBI). All outcome measures were assessed before the training and at the end of the 4-week training.
Results
After the 4-week intervention, TIS, BBS, FAC, and K-MBI scores showed improvement in both LDT and HDT groups. Furthermore, the improvements in TIS scores and its subscales were significantly greater in the HDT group than in the LDT group (p<0.05).
Conclusion
TCT using TSRRBT could be an additional treatment for the conventional rehabilitation therapy of chronic stroke patients with poor sitting balance. HDT may provide more beneficial effects on improving patients’ sitting balance than LDT.

Citations

• Investigation of the reliability and validity of the Turkish version of the Sitting Balance Scale in individuals with stroke
  Kübra Çapraz, Saniye Aydoğan Arslan, Teoman Çolak
  Acta Neurologica Belgica.2024; 124(1): 81.     CrossRef
• Effects of trunk exercises using virtual reality technology on trunk performance and impairment post stroke: a systematic review and meta-analysis
  Norah A Alhwoaimel, Aqeel M Alenazi, Ahmad S Alhowimel, Bader A Alqahtani, Mohammed M Alshehri
  Topics in Stroke Rehabilitation.2024; 31(4): 399.     CrossRef
• A Strong Core for a Strong Recovery: A Scoping Review of Methods to Improve Trunk Control and Core Stability of People with Different Neurological Conditions
  Giorgia Marchesi, Greta Arena, Alice Parey, Alice De Luca, Maura Casadio, Camilla Pierella, Valentina Squeri
  Applied Sciences.2024; 14(11): 4889.     CrossRef
• Video Game-Based Trunk Exercises for Rehabilitation in Chronic Stroke Survivors: A Mixed-Methods Feasibility Study
  Norah A. Alhwoaimel, Ann-Marie Hughes, Martin Warner, Aqeel M. Alenazi, Mohammed M. Alshehri, Bader A. Alqahtani, Ahmed S. Alhowimel, Richard Wagland, Simon Brown, Ruth Turk
  Sensors.2024; 24(21): 6830.     CrossRef
• Trunk training following stroke
  Liselot Thijs, Eline Voets, Stijn Denissen, Jan Mehrholz, Bernhard Elsner, Robin Lemmens, Geert SAF Verheyden
  Cochrane Database of Systematic Reviews.2023;[Epub]     CrossRef
• A Novel Trunk Rehabilitation Robot Based Evaluation of Seated Balance Under Varying Seat Surface and Visual Conditions
  Amre Eizad, Hosu Lee, Sanghun Pyo, Muhammad Raheel Afzal, Sung-Ki Lyu, Jungwon Yoon
  IEEE Access.2020; 8: 204902.     CrossRef
• Effects of Breathing Exercise in the Water on Pulmonary Function and Maximum Phonation Time of Children with Cerebral Palsy
  Je-Wook Lee, Gak Hwangbo
  Journal of The Korean Society of Physical Medicine.2019; 14(3): 91.     CrossRef

Objective
To investigate the effects of hand training using low-frequency repetitive transcranial magnetic stimulation (rTMS) within the aftereffect period on hand function in patients with subacute stroke.
Methods
The subacute stroke patients with hand weaknesses were divided randomly into two groups. Patients in the intervention group underwent hand training within the aftereffect period, that is, immediately after receiving low-frequency rTMS treatment. Patients in the control group underwent hand training 2 hours after the lowfrequency rTMS treatment. A manual function test (MFT) for ‘grasp and pinch’ and ‘hand activities’; a manual muscle test (MMT) for ‘grasp’, ‘release’, and ‘abductor pollicis brevis (APB)’; and the Modified Ashworth Scale for finger flexion were performed and measured before and immediately after combined therapy as well as 2 weeks after combined therapy.
Results
Thirty-two patients with hand weakness were enrolled in this study. The intervention group patients showed more improvements in grasp MMT and MMT APB tested immediately after combined therapy. However, the changes in all measurements were not significantly different between the two groups 2 weeks after the combined therapy. In both groups, hand functions improved significantly immediately after combined therapy and 2 weeks after combined therapy.
Conclusion
Hand training immediately after low-frequency rTMS showed more rapid improvement in the motor power of hands than hand training conducted 2 hours after low-frequency rTMS. Our results suggest that conducting hand training immediately after low-frequency rTMS could be an improved useful therapeutic option in subacute stroke patients.

Citations

• Combined effect of repetitive transcranial magnetic stimulation and physical exercise on cortical plasticity
  Ya-Wen Yang, Wen-Xiu Pan, Qing Xie
  Neural Regeneration Research.2020; 15(11): 1986.     CrossRef
• Effect of Combined Therapy of Robot and Low-Frequency Repetitive Transcranial Magnetic Stimulation on Hemispatial Neglect in Stroke Patients
  Sang Beom Kim, Kyeong Woo Lee, Jong Hwa Lee, Sook Joung Lee, Jin Gee Park, Joung Bok Lee
  Annals of Rehabilitation Medicine.2018; 42(6): 788.     CrossRef

Objective
To investigate the post-stroke rehabilitation status according to stroke severity using the database of the Korean Health Insurance Review and Assessment Service.
Methods
The data of patients admitted to the neurology departments of 12 hospitals within 7 days of onset of ischemic stroke were collected. A total of 2,895 patients hospitalized between November 2010 and December 2011 were included. The patients were classified into three groups according to their initial National Institutes of Health Stroke Scale (NIHSS) scores (mild, ≤5; moderate, >5 and ≤13; and severe, >13). Length of hospital stay (LoS) with rehabilitation, NIHSS score after acute care, and scores on modified Rankin Scale (mRS) were examined at 1 year post-stroke according to stroke severity and ongoing rehabilitation.
Results
The total LoS for ongoing rehabilitation significantly increased with stroke severity (mild, 91.66±149.70; moderate, 197.26±241.93; severe, 263.50±275.75 days; p<0.01). However, the proportion of LoS with ongoing rehabilitation to the total LoS tended to decline with increasing stroke severity (mild, 77.93±29.50, p<0.01; moderate, 71.83±32.13; severe, 62.29±37.19). The home discharge rate of the group that underwent continuous inpatient rehabilitation was significantly higher in patients with moderate and severe stroke, respectively (14.2% vs. 0.0%, p<0.001; 7.4% vs. 0.0%, p=0.032).
Conclusion
This study showed that intermittent rehabilitation was often provided after acute care, whereas ongoing rehabilitation positively affected rate of home discharge in patients with moderate and severe stroke in Korea. These results represent evidence for improving the healthcare system to promote adequate rehabilitation in the future.

Citations

• Predictors of Burden for First-Ever Stroke Survivor’s Long-Term Caregivers: A Study of KOSCO
  Jin-Won Lee, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Junhee Han, Jeonghoon Ahn, Yun-Hee Kim, Min-Keun Song, Won Hyuk Chang
  Medicina.2024; 60(4): 559.     CrossRef
• Toward clearer recognition and easier usefulness: development of a cross-lingual atherosclerotic cerebrovascular disease ontology
  Hetong Ma, Liu Shen, Jiayang Wang, Shilong Wang, Min Wang, Meng Wang, Zixiao Li, Jiao Li
  Database.2024;[Epub]     CrossRef
• Effect of the Frequency of Rehabilitation Treatments on the Long-Term Mortality of Stroke Survivors with Mild-to-Moderate Disabilities under the Korean National Health Insurance Service System
  Dougho Park, Kang Ju Son, Jong Hun Kim, Hyoung Seop Kim
  Healthcare.2023; 11(11): 1587.     CrossRef
• Over- and under-supply of inpatient rehabilitation after stroke without a post-acute rehabilitation system: a nationwide retrospective cohort study
  Suk Won Bae, Junhyun Kwon, Hyung-Ik Shin
  Frontiers in Neurology.2023;[Epub]     CrossRef
• Stroke Rehabilitation Fact Sheet in Korea
  Se Hee Jung
  Annals of Rehabilitation Medicine.2022; 46(1): 1.     CrossRef
• Causes and Trends of Disabilities in Community-Dwelling Stroke Survivors: A Population-Based Study
  Yeon Woo Ju, Jung Soo Lee, Young-Ah Choi, Yeo Hyung Kim
  Brain & Neurorehabilitation.2022;[Epub]     CrossRef
• Determining the Optimal Administration Conditions under Which MIF Exerts Neuroprotective Effects by Inducing BDNF Expression and Inhibiting Apoptosis in an In Vitro Stroke Model
  Chul Jung, Mi Hee Kim, Ye Yeong Kim, Ji Ae Kim, Eun Jae Ko, Seung Hak Lee, Dae Yul Kim
  Brain Sciences.2021; 11(2): 280.     CrossRef
• Korean Model for Post-acute Comprehensive rehabilitation (KOMPACT): The Study Protocol for a Pragmatic Multicenter Randomized Controlled Study on Early Supported Discharge
  Won Kee Chang, Won-Seok Kim, Min Kyun Sohn, Sungju Jee, Yong-Il Shin, Sung-Hwa Ko, Minsu Ock, Hyun Joo Kim, Nam-Jong Paik
  Frontiers in Neurology.2021;[Epub]     CrossRef
• Does Hip Bone Density Differ between Paretic and Non-Paretic Sides in Hemiplegic Stroke Patients? and Its Relationship with Physical Impairment
  Hoo Young Lee, Jung Hyun Park, Hyanglim Lee, Tae-Woo Kim, Seung Don Yoo
  Journal of Bone Metabolism.2020; 27(4): 237.     CrossRef

Objective
To determine the validity and reliability of the Korean version of the Coma Recovery Scale-Revised (K-CRSR) for evaluation of patients with a severe brain lesion.
Methods
With permission from Giacino, the developer of the Coma Recovery Scale Revised (CRSR), the scale was translated into Korean and back-translated into English by a Korean physiatrist highly proficient in English, and then verified by the original developer. Adult patients with a severe brain lesion following traumatic brain injury, stroke, or hypoxic brain injury were examined. To assess the inter-rater reliability, all patients were tested with K-CRSR by two physiatrists individually. To determine intra-rater reliability, the same test was re-administered by the same physiatrists after three days.
Results
Inter-rater reliability (k=0.929, p<0.01) and intra-rater reliability (k=0.938, p<0.01) were both high for total K-CRSR scores. Inter- and intra-rater agreement rates were very high (94.9% and 97.4%, respectively). The total K-CRSR score was significantly correlated with K-GCS (r=0.894, p<0.01), demonstrating sufficient concurrent validity.
Conclusion
K-CRSR is a reliable and valid instrument for the assessment of patients with brain injury by trained physiatrists. This scale is useful in differentiating patients in minimally conscious state from those in vegetative state.

Citations

• Reliability and validation of the Japanese version of the coma recovery scale-revised (CRS-R)
  Takayuki Kitano, Joseph T. Giacino, Yelena Bodien, Abigail Waters, Daichi Hioki, Junko Shinya, Teiji Nakayama, Shohei Ohgi
  Brain Injury.2024; 38(4): 249.     CrossRef
• Cerebrolysin Concentrate: Therapeutic Potential for Severe Oral Apraxia After Stroke: A Case Report
  Hyeonwoo Jeon, Doo Young Kim
  Brain & Neurorehabilitation.2024;[Epub]     CrossRef
• Safety and therapeutic effects of personalized transcranial direct current stimulation based on electrical field simulation for prolonged disorders of consciousness: study protocol for a multi-center, double-blind, randomized controlled trial
  Mi-Jeong Yoon, Hyun Mi Oh, TaeYeong Kim, Soo-Jin Choi, Woo Hee Choi, Hong Soo Jung, Sung Chul Lim, Yeun Jie Yoo, Hye Jung Park, Bo Young Hong, Geun-Young Park, Donghyeon Kim, Tae-Woo Kim, Sun Im, Seong Hoon Lim
  Frontiers in Neurology.2023;[Epub]     CrossRef
• Behavioral Assessment of Patients with Disorders of Consciousness
  Yelena G. Bodien, Douglas I. Katz, Nicholas D. Schiff, Joseph T. Giacino
  Seminars in Neurology.2022; 42(03): 249.     CrossRef
• Prolonged Disorders of Consciousness
  Daeyoung Kim
  Journal of the Korean Neurological Association.2020; 38(1): 9.     CrossRef
• Neurobehavioral recovery in patients who emerged from prolonged disorder of consciousness: a retrospective study
  Hoo Young Lee, Jung Hyun Park, Ae Ryoung Kim, Misun Park, Tae-Woo Kim
  BMC Neurology.2020;[Epub]     CrossRef

Objective
To assess the efficacy of a 4-week swallowing rehabilitation program combined with pyriform sinus ballooning in patients with post-stroke dysphagia (PSD).
Methods
We evaluated a total of 30 patients (n=30) with PSD who were admitted to our medical institution between May of 2014 and October of 2016. These patients were randomly assigned to either the trial group (n=15; a 20-minute conventional rehabilitation followed by a 10-minute pyriform sinus ballooning) or the control group (n=15; a 30-minute conventional rehabilitation). In these patients, the efficacy outcome measures were pharyngeal remnant, the pharyngeal transit time, the Penetration Aspiration Scale (PAS) scores and the Videofluoroscopic Dysphagia Scale (VDS) scores. We compared the differences in efficacy outcome measures at 4 weeks from baseline between the two groups.
Results
There were significant changes in the pharyngeal remnant, the pharyngeal transit time, the PAS scores and the VDS scores at 4 weeks from baseline between the two groups (p<0.0001, p=0.0001, p<0.0001, and p=0.0048, respectively). There were no treatment-emergent adverse events in our series.
Conclusion
Our 4-week rehabilitation program combined with pyriform sinus ballooning is an effective and safe modality in patients with PSD. However, further large-scale, long-term, and multi-center studies are needed to corroborate our results.

Citations

• Clinical signs to predict the severity of dysphagia in Acute Ischemic Stroke patients
  Huijun Zhou, Shengyan Huang, Kinji Arikawa, Jun Zhu, Ting Ye, Qiang Dong
  Clinical Neurology and Neurosurgery.2024; 236: 108091.     CrossRef
• Research hotspots and frontiers in post-stroke dysphagia: a bibliometric analysis study
  Bilian Guo, Mengwei Liu, Zhiyong Wang, Zhipeng Yan
  Frontiers in Neurology.2024;[Epub]     CrossRef
• Therapeutic effects of deep pharyngeal electrical stimulation combined with modified masako maneuver on aspiration in patients with stroke
  Bo-Ye Ni, Hua-Ping Jin, Wei Wu
  NeuroRehabilitation.2024; 54(3): 391.     CrossRef
• Clinical study on swallowing function of brainstem stroke by tDCS
  Huiwen Mao, Yi Lyu, Yan Li, Lin Gan, Jiawei Ni, Liang Liu, Zhengguang Xiao
  Neurological Sciences.2022; 43(1): 477.     CrossRef
• European Stroke Organisation and European Society for Swallowing Disorders guideline for the diagnosis and treatment of post-stroke dysphagia
  Rainer Dziewas, Emilia Michou, Michaela Trapl-Grundschober, Avtar Lal, Ethem Murat Arsava, Philip M Bath, Pere Clavé, Jörg Glahn, Shaheen Hamdy, Sue Pownall, Antonio Schindler, Margaret Walshe, Rainer Wirth, David Wright, Eric Verin
  European Stroke Journal.2021; 6(3): LXXXIX.     CrossRef
• Fonoaudiología En Salas De Urgencias: Perspectiva Desde Una Revisión Documental
  Johanna Rodríguez Riaño, DANIELA MARCELA QUECHO RODRIGUEZ, MARIA PAULA RINCON PINILLA, PAULA VANESSA GARAVITO HERNÁNDEZ, DANIELA MARCELA QUECHO RODRIGUEZ, MARIA PAULA RINCON PINILLA, PAULA VANESSA GARAVITO HERNÁNDEZ
  Areté.2021;[Epub]     CrossRef
• Fonoaudiología En Salas De Urgencias: Perspectiva Desde Una Revisión Documental
  Johanna Rodríguez Riaño, DANIELA MARCELA QUECHO RODRIGUEZ, MARIA PAULA RINCON PINILLA, PAULA VANESSA GARAVITO HERNÁNDEZ, DANIELA MARCELA QUECHO RODRIGUEZ, MARIA PAULA RINCON PINILLA, PAULA VANESSA GARAVITO HERNÁNDEZ
  Areté.2021; 21(1): 125.     CrossRef
• Diagnosis and treatments for oropharyngeal dysphagia: effects of capsaicin evaluated by newly developed ultrasonographic method
  Rui Nakato, Noriaki Manabe, Kozo Hanayama, Hiroaki Kusunoki, Jiro Hata, Ken Haruma
  Journal of Smooth Muscle Research.2020; 56: 46.     CrossRef

Objective
To investigate the influence of a nasogastric tube (NGT) on swallowing simulated saliva in stroke patients.
Methods
Three groups of participants were enrolled into the study: group A (20 stroke patients with a NGT), a control group B (25 stroke patients without a NGT), and group C (25 healthy adults with no brain lesions or dysphagia). Participants swallowed 1 mL of water to simulate saliva. Patients in group A were tested twice: once with a NGT (group A1) and once after the NGT was removed (group A2). The distance of hyoid bone movement was measured by subtracting the shortest distance between the mandible and hyoid bone (S) from the distance at resting state (R) measured with ultrasonography. The degree of the movement was calculated by (R–S)/R. The trajectory area of hyoid bone movement (Area) and the interval between the beginning of hyoid bone movement and the moment of the shortest hyoid−mandible approximation (Interval) was calculated by a computer program.
Results
From group A: R–S and (R–S)/R of group A2 at 1.14±0.36 cm and 0.30±0.09 cm and were significantly greater than those of group A1 at 0.81±0.36 cm and 0.22±0.08 cm (p=0.009 and p=0.005). After removing the NGT as seen in group A2, R–S and (R–S)/R were improved to the level of those of group B at 1.20±0.32 cm and 0.30±0.09 cm (p=0.909 and p=0.997). The Area of group A2 was larger and the Interval of group A2 was shorter than those of group A1 though a comparison of these factors between A2 and A1 did not show a statistically significant difference.
Conclusion
A NGT interferes with the movement of the hyoid bone when swallowing 1 mL of water in stroke patients though the movement is restored to normal after removing the NGT.

Citations

• Methodological Procedures to Acquire and Analyze Ultrasound Images of Swallowing: A Scoping Review
  Rodrigo Alves de Andrade, Leandro de Araújo Pernambuco, Aline Natallia Simões de Almeida, Maria Eduarda da Costa Pinto Mulatinho, Edyanny Nathalya Ferreira dos Santos, Hilton Justino da Silva
  Dysphagia.2025; 40(1): 1.     CrossRef
• Hyoid Bone Movement During Swallowing in Female Thyroidectomy Patients: A Kinematic Ultrasound Study
  Desiré Dominique Diniz de Magalhães, Jayne de Freitas Bandeira, Bianca Oliveira Ismael da Costa, Ary Serrano Santos, Ricardo Vieira Santos, Hilton Justino da Silva, Hipólito Virgílio Magalhães Junior, Leandro Pernambuco
  Dysphagia.2024; 39(5): 956.     CrossRef
• Análise ultrassonográfica da distância do osso hioide em indivíduos com disfagia orofaríngea neurogênica
  Simone Galli Rocha Bragato, Roberta Gonçalves da Silva, Larissa Cristina Berti
  CoDAS.2024;[Epub]     CrossRef
• Ultrasonographic analysis of the hyoid bone distance in individuals with neurogenic oropharyngeal dysphagia
  Simone Galli Rocha Bragato, Roberta Gonçalves da Silva, Larissa Cristina Berti
  CoDAS.2024;[Epub]     CrossRef
• The Effect of Oral Diet Training in Indwelling Nasogastric Tube Patients with Prolonged Dysphagia
  Byung-chan Choi, Sook Joung Lee, Eunseok Choi, Sangjee Lee, Jungsoo Lee
  Nutrients.2024; 16(15): 2424.     CrossRef
• Kinematic Measurements of Swallowing by Ultrasound: A Scoping Review
  S. L. P. Giovanna da Silva Martins, Manuela Leitão de Vasconcelos, Jayne de Freitas Bandeira, Desiré Dominique Diniz de Magalhães, Giorvan Anderson dos Santos Alves, Leandro Pernambuco
  Dysphagia.2024;[Epub]     CrossRef
• Effect of Intermittent Oro-Esophageal Tube Feeding in Bulbar Palsy After Ischemic Stroke: A Randomized Controlled Study
  Hongji Zeng, Weijia Zhao, Junfa Wu, Jihong Wei, Heping Li, Liugen Wang, Xi Zeng
  Stroke.2024; 55(5): 1142.     CrossRef
• Abordagem quantitativa por ultrassonografia para análise do movimento do osso hioide durante a deglutição: revisão integrativa
  Desiré Dominique Diniz de Magalhães, Jayne de Freitas Bandeira, Leandro Pernambuco
  CoDAS.2023;[Epub]     CrossRef
• Quantitative approach to analyze hyoid bone movement during swallowing by ultrasound: an integrative review
  Desiré Dominique Diniz de Magalhães, Jayne de Freitas Bandeira, Leandro Pernambuco
  CoDAS.2023;[Epub]     CrossRef
• Hyolaryngeal Movement During Normal and Effortful Swallows Determined During Ultrasonography
  Mariana M. Bahia, Soren Y. Lowell
  Journal of Speech, Language, and Hearing Research.2023; 66(10): 3856.     CrossRef
• Reliability of Ultrasound Examination of Hyoid Bone Displacement Amplitude: A Systematic Review and Meta-Analysis
  Rodrigo Alves de Andrade, Maria das Graças Wanderley do Sales Coriolano, Eduarda Lopes Honorato de Souza, Jamilly Henrique Costa da Silva, Maria Deluana da Cunha, Leandro Pernambuco, Vanessa Veis Ribeiro, Hilton Justino da Silva
  Dysphagia.2022; 37(6): 1375.     CrossRef
• Quantitative Ultrasound Assessment of Hyoid Bone Displacement During Swallowing Following Thyroidectomy
  Bianca Oliveira Ismael da Costa, Darlyane de Souza Barros Rodrigues, Desiré Dominique Diniz de Magalhães, Ary Serrano Santos, Ricardo Vieira Santos, Elma Heitmann Mares Azevedo, Anna Alice Almeida, Leandro Pernambuco
  Dysphagia.2021; 36(4): 659.     CrossRef
• Time trends of colorectal cancer incidence and associated lifestyle factors in South Korea
  Hayeong Khil, Sung Min Kim, SungEun Hong, Hyeon Min Gil, Eugene Cheon, Dong Hoon Lee, Young Ae Kim, NaNa Keum
  Scientific Reports.2021;[Epub]     CrossRef
• May ultrasonography be considered a useful tool for bedside screening of dysphagia in patients with acute stroke? A cohort study
  Alessandro PICELLI, Angela MODENESE, Elena POLETTO, Valentina BUSINARO, Valentina VARALTA, Marialuisa GANDOLFI, Bruno BONETTI, Nicola SMANIA
  Minerva Medica.2021;[Epub]     CrossRef
• Effects of a food preparation program on dietary well-being for stroke patients with dysphagia
  Shu-Chi Lin, Kuan-Hung Lin, Yi-Chi Tsai, En-Chi Chiu
  Medicine.2021; 100(25): e26479.     CrossRef
• Best Practice Recommendations for Dysphagia Management in Stroke Patients: A Consensus from a Portuguese Expert Panel
  Isabel de Jesus Oliveira, Germano Rodrigues Couto, Rosa Vilares Santos, Ana Maria Campolargo, Cláudia Lima, Pedro Lopes Ferreira
  Portuguese Journal of Public Health.2021; 39(3): 145.     CrossRef
• Epiglottic Retroflexion is a Key Indicator of Functional Recovery of Post-stroke Dysphagia
  Ji Soo Choi, Hyun Bang, Goo Joo Lee, Han Gil Seo, Byung-Mo Oh, Tai Ryoon Han
  Annals of Rehabilitation Medicine.2020; 44(1): 1.     CrossRef
• Avoiding the Downward Spiral After Stroke: Early Identification and Treatment of Dysphagia
  Rachel Mulheren, Alba Azola, Marlís González-Fernández
  Current Physical Medicine and Rehabilitation Reports.2020; 8(4): 469.     CrossRef

Objective
To investigate the characteristics and risk factors of dysphagia using the videofluoroscopic dysphagia scale (VDS) with a videofluoroscopic swallowing study (VFSS) in patients with acute cerebral infarctions.
Methods
In this retrospective study, the baseline VFSS in 275 stroke patients was analyzed. We divided patients into 8 groups according to lesion areas commonly observed on brain magnetic resonance imaging. Dysphagia characteristics and severity were evaluated using the VDS. We also analyzed the relationship between clinical and functional parameters based on medical records and VDS scores.
Results
In comparison studies of lesions associated with swallowing dysfunction, several groups with significant differences were identified. Apraxia was more closely associated with cortical middle cerebral artery territory lesions. Vallecular and pyriform sinus residue was more common with lesions in the medulla or pons. In addition, the results for the Korean version of the Modified Barthel Index (K-MBI), a functional assessment tool, corresponded to those in the quantitative evaluation of swallowing dysfunctions.
Conclusion
A large cohort of patients with cerebral infarction was evaluated to determine the association between brain lesions and swallowing dysfunction. The results can be used to establish a specific treatment plan. In addition, the characteristic factors associated with swallowing dysfunctions were also confirmed.

Citations

• Post-stroke dysphagia: identifying the evidence missing
  Zicong Wang, Ran Shi, Paulo Moreira
  Frontiers in Medicine.2025;[Epub]     CrossRef
• Correlation between lesion location and dysphagia characteristics in post-stroke patients
  Qing-lu Yang, Yang Chen, Xue-jie Wang, Hui-ying Qiu, Meng-ting Chen, Xu-hui Zhou, Chu-yao Jian, Shao-feng Zhao
  Journal of Stroke and Cerebrovascular Diseases.2024; 33(6): 107682.     CrossRef
• Prevalence, recovery and phenotype of dysphagia in patients with ischaemic cerebellar stroke
  Jan Hendrik Schaefer, Felix Luft, Alexander Seiler, Elena Harborth, Sara Kaffenberger, Christoph Polkowski, Christian Foerch, Sriramya Lapa
  European Journal of Neurology.2024;[Epub]     CrossRef
• The Role of the Cerebellum in Swallowing
  Ayodele Sasegbon, Shaheen Hamdy
  Dysphagia.2023; 38(2): 497.     CrossRef
• Brain Activation Site of Laryngeal Elevation During Swallowing: An fMRI Study
  Zhiyi Zhang, Ling Yan, Xiangxin Xing, Lequn Zhu, Haoyue Wu, Shuangjing Xu, Ping Wan, Ruiying Ding
  Dysphagia.2023; 38(1): 268.     CrossRef
• Dysphagia following cerebellar stroke: analyzing the contribution of the cerebellum to swallowing function
  Masoume Hajipour, Davood Sobhani-Rad, Shahryar Zainaee, Mohammad Taghi Farzadfar, Saeedeh Hajebi Khaniki
  Frontiers in Neurology.2023;[Epub]     CrossRef
• Neural correlates of cricopharyngeal dysfunction after supratentorial stroke: A voxel-based lesion-symptom mapping with propensity score matched case–control
  Jun Yup Kim, Seo Yeon Yoon, Jinna Kim, Yong Wook Kim
  International Journal of Stroke.2022; 17(2): 207.     CrossRef
• Voxel-based lesion symptom mapping analysis for dysphagia in stroke patients with isolated cerebellar lesions
  Hyun Im Moon, Yoon Jeong Jeong, Ji Hyun Suh
  Journal of Neural Transmission.2022; 129(1): 65.     CrossRef
• Usefulness of the Modified Videofluoroscopic Dysphagia Scale in Choosing the Feeding Method for Stroke Patients with Dysphagia
  Byung Joo Lee, Hyoshin Eo, Changbae Lee, Donghwi Park
  Healthcare.2021; 9(6): 632.     CrossRef
• Correlation of Swallowing Function With Bilateral Diaphragmatic Movement in Hemiplegic Stroke Patients
  Ra Yu Yun, Ho Eun Park, Ji Won Hong, Yong Beom Shin, Jin A Yoon
  Annals of Rehabilitation Medicine.2019; 43(2): 156.     CrossRef

Objective
To validate the relationship between residual walking ability and monthly care cost as well as long-term care insurance (LTCI) certification level in elderly patients after surgical treatment for hip fractures in Japan.
Methods
Elderly patients aged >75 years who underwent surgical treatment for hip fractures in our hospital were included. The preand post-surgical (6-month) walking ability and LTCI certification and the presence or absence of dementia was determined from medical records and questionnaires. Walking ability was classified into 6 levels used in our daily medical practice. Based on these data, we correlated the relationship between walking ability and the LTCI certification level. Further, based on the official statistics pertaining to the average monthly costs per person at each LTCI certification level, we evaluated the relationship between walking ability and monthly care cost.
Results
A total of 105 cases (mean age, 80.2 years; 16 men; 39 patients with dementia) were included. The correlation between walking ability and average monthly cost per person as well as LTCI certification level at 6 months postoperatively (r=0.58) was demonstrated. The correlation was found in both groups with and without dementia.
Conclusion
The ability to walk reduced the cost of care in elderly patients who experienced hip fracture, regardless of the presence of dementia.

Citations

• Mortality following hip fracture surgery in patients with dementia: a Swedish multiple national register study
  Michael Axenhus, Sara J. Hägg, Maria Eriksdotter, Margareta Hedström, Dorota Religa
  European Geriatric Medicine.2025; 16(2): 541.     CrossRef
• Level of implementation of pain management and early mobilization strategies to prevent delirium in geriatric trauma patients: A mixed-methods study
  Maryline Beaudoin, Etienne L. Belzile, Céline Gélinas, David Trépanier, Marcel Émond, Marc-Aurèle Gagnon, Mélanie Bérubé
  International Journal of Orthopaedic and Trauma Nursing.2024; 52: 101050.     CrossRef
• Combined nutritional status and activities of daily living disability is associated with one-year mortality after hip fracture surgery for geriatric patients: a retrospective cohort study
  Ying Chen, Ying Guo, Gang Tong, Yu He, Ruihua Zhang, Qi Liu
  Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
• Study on the predictive model of delirium risk after surgery for elderly hip fractures based on meta-analysis
  Weiliang Wan, Liyun Li, Zhuan Zou, Wenjie Chen
  European Geriatric Medicine.2024; 16(1): 245.     CrossRef
• Impact of dementia on post-hip fracture walking ability: a stratified analysis based on pre-fracture mobility in Swedish cohorts of older adults
  Philip D. G. Burenstam Linder, Dorota D. Religa, Fredrik Gustavsson, Maria Eriksdotter, Margareta Hedström, Sara Hägg
  BMC Geriatrics.2024;[Epub]     CrossRef
• The impact of early mobility on functional recovery after hip fracture surgery
  Shota Mashimo, Junya Kubota, Hiroyuki Sato, Azusa Saito, Stuart Gilmour, Nobuto Kitamura
  Disability and Rehabilitation.2023; 45(26): 4388.     CrossRef
• Association of preoperative nutritional status evaluated by the controlling nutritional status score with walking independence at 180 days postoperatively: a prospective cohort study in Chinese older patients with hip fracture
  Xinqun Cheng, Wei Chen, Jincheng Yan, Zhenbang Yang, Chengsi Li, Dongwei Wu, Tianyu Wang, Yingze Zhang, Yanbin Zhu
  International Journal of Surgery.2023; 109(9): 2660.     CrossRef
• The effects of dementia on the prognosis and mortality of hip fracture surgery: a systematic review and meta-analysis
  Mingzhuang Hou, Yijian Zhang, Angela Carley Chen, Tao Liu, Huilin Yang, Xuesong Zhu, Fan He
  Aging Clinical and Experimental Research.2021; 33(12): 3161.     CrossRef
• Prognostic factors for 1-year functional outcome, quality of life, care demands, and mortality after surgery in Taiwanese geriatric patients with a hip fracture: a prospective cohort study
  Yu-Pin Chen, Yi-Jie Kuo, Chieh-hsiu Liu, Pei-Chun Chien, Wei-Chun Chang, Chung-Ying Lin, Amir H. Pakpour
  Therapeutic Advances in Musculoskeletal Disease.2021;[Epub]     CrossRef
• Poor Activities of Daily Living Function Reflect Poor Quality of Life after Hip Fracture Surgery for Geriatric Patients
  Wei-Ting Chang, Yi-Jie Kuo, Yu-Yun Huang, Ming-Jr Tsai, Yu-Pin Chen
  Asian Journal of Social Health and Behavior.2019; 2(2): 41.     CrossRef

Objective
To investigate changes of cardiac and muscle damage markers in exercise-induced hypertension (EIH) runners before running (pre-race), immediately after completing a 100-km ultramarathon race, and during the recovery period (24, 72, and 120 hours post-race).
Methods
In this observational study, volunteers were divided into EIH group (n=11) whose maximum systolic blood pressure was ≥210 mmHg in graded exercise testing and normal exercise blood pressure response (NEBPR) group (n=11). Their blood samples were collected at pre-race, immediately after race, and at 24, 72, and 120 hours post-race.
Results
Creatine kinase (CK) and cardiac troponin I (cTnI) levels were significantly higher in EIH group than those in the NEBPR group immediately after race and at 24 hours post-race (all p<0.05). However, lactate dehydrogenase (LDH), creatine kinase-myocardial band (CKMB), or CKMB/CK levels did not show any significant differences between the two groups in each period. N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were significantly higher in EIH group than those in NEBPR group immediately after race and at 24 and 72 hours postrace (all p<0.05). A high sensitivity C-reactive protein (hs-CRP) level was significantly higher in EIH group than that in NEBPR group at 24 hours post-race (p<0.05).
Conclusion
The phenomenon of higher inflammatory and cardiac marker levels in EIH group may exaggerate cardiac volume pressure and blood flow restrictions which in turn can result in cardiac muscle damage. Further prospective studies are needed to investigate the chronic effect of such phenomenon on the cardiovascular system in EIH runners.

Citations

• Possible Mechanisms for Adverse Cardiac Events Caused by Exercise-Induced Hypertension in Long-Distance Middle-Aged Runners: A Review
  Young-Joo Kim, Kyoung-Min Park
  Journal of Clinical Medicine.2024; 13(8): 2184.     CrossRef
• Relationship between echocardiographic characteristics and cardiac biomarkers during long-distance trail running
  Romain Jouffroy, Hélène Hergault, Juliana Antero, Antoine Vieillard Baron, Nicolas Mansencal
  Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
• Electrical Cardiometry and Cardiac Biomarkers in 24-h and 48-h Ultramarathoners
  Che-Hung Liu, Li-Hua Li, Ming-Long Chang, Wei-Fong Kao, Chorng-Kuang How, Jiun-I Lai, Yen-Kuang Lin, Yu-Hui Chiu, Wen-Han Chang
  International Journal of Sports Medicine.2021; 42(11): 1035.     CrossRef
• Exercise-Induced Cardiac Troponin Elevations: From Underlying Mechanisms to Clinical Relevance
  Vincent L. Aengevaeren, Aaron L. Baggish, Eugene H. Chung, Keith George, Øyunn Kleiven, Alma M.A. Mingels, Stein Ørn, Rob E. Shave, Paul D. Thompson, Thijs M.H. Eijsvogels
  Circulation.2021; 144(24): 1955.     CrossRef
• Long‐term biological variability and the generation of a new reference interval for plasma N‐terminal pro‐B‐type natriuretic peptide in Labrador retrievers
  S. Gomart, D. Allaway, M. Harrison, D. Dickson, J. Seo, L. Ferasin, J. R. Payne, M. J. Hezzell, K. Borgeat
  Journal of Small Animal Practice.2020; 61(6): 368.     CrossRef
• Acute Responses of Novel Cardiac Biomarkers to a 24-h Ultra-Marathon
  Aleksandra Żebrowska, Zbigniew Waśkiewicz, Pantelis T. Nikolaidis, Rafał Mikołajczyk, Damian Kawecki, Thomas Rosemann, Beat Knechtle
  Journal of Clinical Medicine.2019; 8(1): 57.     CrossRef
• Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation
  Øyunn Kleiven, Torbjørn Omland, Øyvind Skadberg, Tor Harald Melberg, Magnus Friestad Bjørkavoll-Bergseth, Bjørn Auestad, Rolf Bergseth, Ole Jakob Greve, Kristin Moberg Aakre, Stein Ørn
  International Journal of Cardiology.2019; 283: 1.     CrossRef

Objective
To evaluate changes in the severity of cervical spinal stenosis (CSS) in flexion and extension and determine whether the rate of change with motion varied with severity.
Methods
The study included 92 symptomatic patients with a mean age of 57.80±10.41, who underwent cervical spine dynamic magnetic resonance imaging. The severity of stenosis was evaluated using a semi-quantitative CSS score, ranging from 0 (no spinal stenosis) to 18 (severe stenosis). Radiological evaluation included flexion, neutral, and extension measurements, as determined by the C2–C7 Cobb angle. The severity of stenosis was represented by the total CSS score. The total CSS score in flexion, neutral, and extension positions was compared using repeated measures one-way analysis of variance. The change rate of stenosis per angle motion (CRSPAM) was defined as change in total CSS score divided by change in Cobb angle. The correlation of CRSPAM with severity of stenosis, represented by total CSS score in neutral position, was evaluated using Pearson correlation analysis.
Results
The total CSS score was significantly higher in extension (6.04±2.68) than in neutral position (5.25±2.47) (p<0.001), and significantly higher in neutral than in flexion position (4.40±2.45) (p<0.001). The CRSPAM was significantly and positively correlated with total CSS score in neutral position in the flexion-extension range (r=0.22, p=0.04) and flexion-neutral range (r=0.27, p=0.01).
Conclusion
In symptomatic CSS patients, the radiological severity of stenosis increases with extension and decreases with flexion. In patients with CSS, the rate of variation in spinal stenosis increases with increased severity.

Citations

• Predictive value of magnetic resonance imaging indications of spinal cord swelling for cervical spondylotic myelopathy prognosis
  Xiao-Nan Tian, Li Zhang, Hong-Ran Liu, Xue-Song Zhang, Ying-Cai Sun, Yong Wang
  Technology and Health Care.2024; 32(1): 151.     CrossRef
• Favorable cervical extension capacity preventing loss of cervical lordosis after laminoplasty due to spontaneous restoration of initial lordosis
  Xiaofei Cheng, Zhiqian Chen, Xiaojiang Sun, Changqing Zhao, Jie Zhao
  The Spine Journal.2024; 24(1): 94.     CrossRef
• Dynamic Flexion-Extension Magnetic Resonance Imaging of the Cervical Spine: An Evolutionary Tool for Diagnosis and Management of Cervical Spondylotic Myelopathy
  Ali Mahdavi, Sina Rasti
  World Neurosurgery.2024; 184: 138.     CrossRef
• Added value of dynamic MRI in assessment of cervical spondylodegenerative diseases
  Menna Ahmad Mohamed Abdalhak, Hossam Mousa Sakr, Mennatallah Hatem Shalaby, Shaimaa Elmetwally El diasty
  Egyptian Journal of Radiology and Nuclear Medicine.2023;[Epub]     CrossRef
• Flexion/Extension Cervical Magnetic Resonance Imaging: A Potentially Useful Tool for Decision-Making in Patients with Symptomatic Degenerative Cervical Spine
  Hazem M.A. Alkosha, Mohamed A. El Adalany, Hesham Elsobky, Asharaf S. Zidan, Amin Sabry, Basem I. Awad
  World Neurosurgery.2022; 164: e1078.     CrossRef
• Best cutoff score of cervical-pedicle thickness as a morphological parameter for predicting cervical central stenosis
  Jungho Choi, Hyung-Bok Park, Taeha Lim, Shin Wook Yi, Sooho Lee, Sukhee Park, SoYoon Park, Jungmin Yi, Young Uk Kim
  Medicine.2022; 101(33): e30014.     CrossRef
• Multidimensional assessment of cervical spondylotic myelopathy patients. Usefulness of a comprehensive score system
  Fabio Pilato, Rosalinda Calandrelli, Marisa Distefano, Francesco Ciro Tamburrelli
  Neurological Sciences.2021; 42(4): 1507.     CrossRef
• The value of dynamic MRI in the treatment of cervical spondylotic myelopathy: a protocol for a prospective randomized clinical trial
  Nanfang Xu, Youyu Zhang, Guangjin Zhou, Qiang Zhao, Shaobo Wang
  BMC Musculoskeletal Disorders.2020;[Epub]     CrossRef
• Dynamic Cord Compression Causing Cervical Myelopathy
  Andrei Fernandes Joaquim, Griffin R. Baum, Lee A. Tan, K. Daniel Riew
  Neurospine.2019; 16(3): 448.     CrossRef

Objective
To assess the nutritional status of Korean patients with spinal cord injury (SCI), identify the predictors of undernutrition, and investigate the relationship between undernutrition and clinical outcomes.
Methods
A retrospective study design was used to determine the nutritional status of 130 patients over 19 years old admitted to the rehabilitation hospital of Yonsei University Health System between June 2015 and February 2017. The nutritional status was assessed using the malnutrition universal screening tool (MUST) and the spinal nutrition screening tool (SNST). The relationship between undernutrition and clinical outcomes was examined by comparing a low-risk group with an at-risk group using a t-test.
Results
Among the SCI patients, 70 (50.8%) were confirmed with undernutrition based on the MUST scores, while 60 (46.2%) had undernutrition based on the SNST scores. It was found that undernutrition has an effect on functional outcomes.
Conclusion
We assessed the undernutrition risk in Korean SCI patients, and found that approximately 50% of the patients were at risk of undernutrition. We also found that undernutrition can affect functional recovery.

Citations

• Multifaceted Pathophysiology and Secondary Complications of Chronic Spinal Cord Injury: Focus on Pressure Injury
  Mario Martínez-Torija, Pedro F. Esteban, Angela Santos-De-La-Mata, Matilde Castillo-Hermoso, Eduardo Molina-Holgado, Rafael Moreno-Luna
  Journal of Clinical Medicine.2025; 14(5): 1556.     CrossRef
• Defining malnutrition in persons with spinal cord injury – does the Global Criteria for Malnutrition work?
  Hanne Bjørg Slettahjell, Maria Bastakis, Fin Biering-Sørensen, Vegard Strøm, Christine Henriksen
  Food & Nutrition Research.2024;[Epub]     CrossRef
• Significance of physical factors on activities of daily living in patients with tetraplegia after spinal cord injury: a retrospective study
  Kimin Yun, Jin-cheol Lim, Onyoo Kim
  BMC Sports Science, Medicine and Rehabilitation.2024;[Epub]     CrossRef
• The risk of malnutrition in patients with spinal cord injury during inpatient rehabilitation–A longitudinal cohort study
  Irene Flury, Gabi Mueller, Claudio Perret
  Frontiers in Nutrition.2023;[Epub]     CrossRef
• Predictive validity of the Mini Nutritional Assessment Short‐Form for rehabilitation patients: A retrospective analysis of the Japan Rehabilitation Nutrition Database
  Shinta Nishioka, Hidetaka Wakabayashi, Jun Kayashita, Yutaka Taketani, Ryo Momosaki
  Journal of Human Nutrition and Dietetics.2021; 34(5): 881.     CrossRef

Objective
To determine a diagnostic cut-off value for the cross-sectional area (CSA) of the radial nerve using ultrasonography for radial neuropathy located at the spiral groove (SG).
Methods
Seventeen patients with electrodiagnostic evidence of radial neuropathy at the SG and 30 healthy controls underwent ultrasonography of the radial nerve at the SG . The CSAs at the SG were compared in the patient and control groups. The CSA at the SG between the symptomatic and asymptomatic sides (ΔSx–Asx and Sx/Asx, respectively) were analyzed to obtain the optimal cut-off value. The relationship between the electrophysiological severity of radial neuropathy and CSA was also evaluated.
Results
Among the variables examined, there were statistically significant differences in the CSA between the patient and control groups, ΔSx–Asx, and Sx/Asx at the SG. In a receiver operating characteristics analysis, the cut-off CSA was 5.75 mm² at the SG (sensitivity 52.9%, specificity 90%), 1.75 mm² for ΔSx–Asx (sensitivity 58.8%, specificity 100%), and 1.22 mm² for Sx/Asx (sensitivity 70.6%, specificity 93.3%) in diagnosing radial neuropathy at the SG. There was no significant correlation between CSA and electrophysiological severity score for either patient group.
Conclusion
The reference value obtained for CSA of the radial nerve at the SG may facilitate investigation of radial nerve pathologies at the SG.

Citations

• Imaging of elbow entrapment neuropathies
  Domenico Albano, Gabriella Di Rocco, Salvatore Gitto, Francesca Serpi, Stefano Fusco, Paolo Vitali, Massimo Galia, Carmelo Messina, Luca Maria Sconfienza
  Insights into Imaging.2025;[Epub]     CrossRef
• Sonographic peripheral nerve cross‐sectional area in adults, excluding median and ulnar nerves: A systematic review and meta‐analysis
  Sarah F. Eby, Masaru Teramoto, Joshua Lider, Madison Lash, Marc Caragea, Daniel M. Cushman
  Muscle & Nerve.2023; 68(1): 20.     CrossRef
• Review Article “Spotlight on Ultrasonography in the Diagnosis of Peripheral Nerve Disease: The Evidence to Date”
  Andrew Hannaford, Steve Vucic, Matthew C Kiernan, Neil G Simon
  International Journal of General Medicine.2021; Volume 14: 4579.     CrossRef
• Ultrasonographic evaluation of common compression neuropathies in the upper limb
  Jung Im Seok
  Annals of Clinical Neurophysiology.2020; 22(1): 1.     CrossRef

Objective
To evaluate if there is a difference in gait pattern when applying two different shapes of energy storing prosthetic feet for trainstibial amputation we conducted a comparative study. Energy storing prosthetic feet for transtibial amputation are increasing in use, but there are few studies that evaluate the effects of the shape of energy storing feet on gait patterns.
Methods
Ten unilateral transtibial amputees were recruited. Two different shapes of dynamic response feet were applied to each subject either 1C30 Trias or 1C60 Triton. The main differences between the two are a split forefoot and the presence of a heel wedge. Spatiotemporal, kinematic, and kinetic data was obtained through gait analysis. Differences between intact and prosthetic side and differences between the two prosthetics were assessed.
Results
On a side to side comparison, cadence asymmetry with 1C30 Trias was observed. Ankle plantarflexion at the end of stance and ankle supination at the onset of preswing was smaller with both prosthetic feet compared to the intact side. Other spatiotemporal, kinematic, and kinetic data showed no significant differences in a side to side comparison. In a comparison between the two prosthetics, stance and swing ratio and ankle dorsiflexion through mid-stance was closer to normal with 1C60 Triton than 1C30 Trias. Other spatiotemporal, kinematic, and kinetic data showed no statistically significant differences between prosthetics.
Conclusion
Both energy storing feet implants showed symmetric gait in unilateral transtibial amputees who are functionally independent in daily living. And 1C60 Triton showed closer to normal gait patterns than 1C30 Trias in our study.

Citations

• A systematic review of energy storing dynamic response foot for prosthetic rehabilitation
  Swapna Sahoo, Rajesh Kumar Mohanty, Aswini Kumar Mohapatra
  Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine.2024; 238(11-12): 1069.     CrossRef
• Therapeutic benefits of lower limb prostheses: a systematic review
  Elke Lathouwers, María Alejandra Díaz, Alexandre Maricot, Bruno Tassignon, Claire Cherelle, Pierre Cherelle, Romain Meeusen, Kevin De Pauw
  Journal of NeuroEngineering and Rehabilitation.2023;[Epub]     CrossRef
• Sprinting performance of individuals with unilateral transfemoral amputation: compensation strategies for lower limb coordination
  Mingyu Hu, Toshiki Kobayashi, Genki Hisano, Hiroto Murata, Daisuke Ichimura, Hiroaki Hobara
  Royal Society Open Science.2023;[Epub]     CrossRef
• Symmetry Function in Trans-Tibial Amputees Gait Supplied with the New Concept of Affordable Dynamic Foot Prosthesis—Case Study
  Michal Murawa, Jakub Otworowski, Sebastian But, Jaroslaw Kabacinski, Lukasz Kubaszewski, Adam Gramala
  Symmetry.2023; 15(8): 1595.     CrossRef
• Coordination of Lower Limb During Gait in Individuals With Unilateral Transfemoral Amputation
  Mingyu Hu, Yufan He, Genki Hisano, Hiroaki Hobara, Toshiki Kobayashi
  IEEE Transactions on Neural Systems and Rehabilitation Engineering.2023; 31: 3835.     CrossRef
• Experimental investigation of gait parameters and stability analysis for unilateral transtibial amputee
  Preeti Chauhan, Amit Kumar Singh, Naresh K Raghuwanshi, Radheshyam Rathore
  Sādhanā.2023;[Epub]     CrossRef
• Biomechanical accommodation to walking with an ankle–foot prosthesis: An exploratory analysis of novice users with transtibial limb loss within the first year of ambulation
  Caitlin E. Mahon, Brad D. Hendershot
  Prosthetics & Orthotics International.2022; 46(5): 452.     CrossRef
• Normalized Kinematic Walking Symmetry Data for Individuals Who Use Lower-Limb Prostheses: Considerations for Clinical Practice and Future Research
  MG Finco, Sarah C. Moudy, Rita M. Patterson
  JPO Journal of Prosthetics and Orthotics.2022;[Epub]     CrossRef
• Foot/Ankle Prostheses Design Approach Based on Scientometric and Patentometric Analyses
  Joel Zagoya-López, Luis Adrián Zúñiga-Avilés, Adriana H. Vilchis-González, Juan Carlos Ávila-Vilchis
  Applied Sciences.2021; 11(12): 5591.     CrossRef
• Biomechanical influences of gait patterns on knee joint: Kinematic & EMG analysis
  Jin Ju Kim, Han Cho, Yulhyun Park, Joonyoung Jang, Jung Woo Kim, Ju Seok Ryu, Riccardo Di Giminiani
  PLOS ONE.2020; 15(5): e0233593.     CrossRef
• Evolution of gait parameters in individuals with a lower-limb amputation during a six-minute walk test
  Sarah Beausoleil, Ludovic Miramand, Katia Turcot
  Gait & Posture.2019; 72: 40.     CrossRef

Injury to the thalamocortical tract (one in the Papez circuit) that leads to memory impairment following brain injury is very rare. In this study, we present a case of partial injury to the thalamocortical tract that causes memory impairment after concurrent thalamic and hippocampal infarct. A 20-year-old male complained of memory impairment 1 month after partial injury to the thalamocortical tract. Using a probabilistic diffusing tensor tractography, it was found that the right thalamocortical tract was thinner than the left thalamocortical tract. However, all other neural tracts including the fornix, cingulum, and mammillothalamic tract were intact on both hemispheres. Therefore, the memory impairment in this patient was considered as being due to thalamic infarct based on the observation that the fornix from hippocampal infarct was intact. This case suggests that the assessment of lesions in the neural tracts of the Papez circuit might be useful for understanding the mechanism of memory impairment following cerebral infarction.

Citations

• Association between scrub typhus encephalitis and diffusion tensor tractography detection of Papez circuit injury: A case report
  Hyeok Gyu Kwon, Jeong-Hee Yang, Jee-Hyun Kwon, Dongseok Yang
  World Journal of Clinical Cases.2021; 9(13): 3194.     CrossRef

Posterior epidural migration of a lumbar intervertebral disc fragment (PEMLIF) is uncommon because of anatomical barriers. It is difficult to diagnose PEMLIF definitively because of its relatively rare incidence and the ambiguity of radiological findings resembling spinal tumors. This case report describes a 76-year-old man with sudden-onset weakness and pain in both legs. Electromyography revealed bilateral lumbosacral polyradiculopathy with a mass-like lesion in L2-3 dorsal epidural space on lumbosacral magnetic resonance imaging (MRI). The lesion showed peripheral rim enhancement on T1-weighted MRI with gadolinium administration. The patient underwent decompressive L2-3 central laminectomy, to remove the mass-like lesion. The excised lesion was confirmed as an intervertebral disc. The possibility of PEMLIF should be considered when rim enhancement is observed in the epidural space on MRI scans and electrodiagnostic features of polyradiculopathy with sudden symptoms of cauda equina syndrome.

Citations

• Posterior epidural migration of thoracic and lumbar disc material: a comprehensive 63-year systematic review with anatomical perspectives
  Shafi Hamid, Madison Kropuenske, Salma Zahran, Ehsan Alimohammadi
  Neurosurgical Review.2025;[Epub]     CrossRef
• Posterior epidural migration of herniated disc: A case series and literature review
  Maria Ilaria Borruto, Andrea Perna, Domenico Alessandro Santagada, Calogero Velluto, Maurizio Genitiempo, Francesco Ciro Tamburrelli, Luca Proietti
  Journal of Neurosciences in Rural Practice.2025; 16: 1.     CrossRef
• Sequestered Lumbar Disc Mimicking Psoas Abscess: A Case Report
  Shu Suzuki, Kazuya Okita, Kazuki Abe, Mizuka Suzuki, Yasunobu Takaki
  Cureus.2025;[Epub]     CrossRef
• Gadolinium-Enhanced 3-Dimensional MRI for Diagnosis and Surgical Planning of Posterior Epidural Migration of Lumbar Disc Fragment
  Yoshinao Koike, Tomomichi Kajino, Shinya Dobashi, Norimasa Iwasaki
  JBJS Case Connector.2024;[Epub]     CrossRef
• Posterior and anterior epidural and intradural migration of the sequestered intervertebral disc: Three cases and review of the literature
  Daphne J. Theodorou, Stavroula J. Theodorou, Yousuke Kakitsubata, Evangelos I. Papanastasiou, Ioannis D. Gelalis
  The Journal of Spinal Cord Medicine.2022; 45(2): 305.     CrossRef
• Posterior epidural intervertebral disc migration and sequestration: A systematic review
  Paolo Palmisciano, Kishore Balasubramanian, Gianluca Scalia, Navraj S. Sagoo, Ali S. Haider, Othman Bin Alamer, Vishal Chavda, Bipin Chaurasia, Harsh Deora, Maurizio Passanisi, Valerio Da Ros, Giuseppe R. Giammalva, Rosario Maugeri, Domenico G. Iacopino,
  Journal of Clinical Neuroscience.2022; 98: 115.     CrossRef
• A Review of the Diagnostic Features of Posteriorly Migrated Lumbar Discs with Reports of Two Cases
  Ajaya Kumar Ayyappan Unnithan
  Neurology India.2022; 70(3): 1213.     CrossRef
• Sequestrated Lumbar Disc Herniation Mimicking Spinal Neoplasm
  Faisal Konbaz, Sami I Aleissa, Fahad Al Helal, Majed Abaalkhail, Waleed Alrogy, Abrar Bin Dohaim, Nasser Albishi
  Cureus.2021;[Epub]     CrossRef
• Posterior epidural sequestrated disc presenting with contralateral radiculopathy: a very rare case
  Withawin Kesornsak, Kanthika Wasinpongwanich, Verapan Kuansongtham
  Spinal Cord Series and Cases.2021;[Epub]     CrossRef
• Dorsal migration of lumbar disc fragments causing cauda equina syndromes: A three case series and literature review
  Shawn Singh Rai, Carlos Rodrigo Goulart, Sepehr Lalezari, Michael Anthony Galgano, Satish Krishnamurthy
  Surgical Neurology International.2020; 11: 175.     CrossRef
• Posterior epidural migration of herniated lumbar disc fragment: a literature review
  Alaa Eldin Elsharkawy, Anne Hagemann, Peter Douglas Klassen
  Neurosurgical Review.2019; 42(4): 811.     CrossRef

Lymphedema is a common complication associated with cancer itself or with cancer treatment. Lymphedema infrequently occurs after drug therapy. Bee venom is one of the materials used in acupuncture, and it has been used in the treatment of a variety of inflammatory diseases including arthritis. We report a 74-year-old male patient with late-onset post-radiation lymphedema provoked by bee venom therapy. He was free of lymphedema for 5 years after the complete remission of prostate cancer which had been treated with transurethral resection and radiation therapy. The patient developed left leg swelling after undergoing bee venom therapy for left hip pain. Computed tomography and lymphoscintigraphy showed lymphedema without tumor recurrence or infection. The lymphatic system was suspected to be injured by bee venom therapy and lymphedema was provoked. Bee venom therapy should be used cautiously in patients prone to lymphedema.

Citations

• Melittin and phospholipase A2: Promising anti-cancer candidates from bee venom
  Ziyan Cui, Zegao Zhou, Ziyan Sun, Jiayue Duan, Runtian Liu, Cheng Qi, Changqing Yan
  Biomedicine & Pharmacotherapy.2024; 179: 117385.     CrossRef
• Pharmacological properties and therapeutic potential of honey bee venom
  Amjad Ullah, Fahad Mohammed Aldakheel, Syed Ishtiaq Anjum, Ghulam Raza, Saeed Ahmad Khan, Ivana Tlak Gajger
  Saudi Pharmaceutical Journal.2023; 31(1): 96.     CrossRef
• Update December 2018
  Francine Blei
  Lymphatic Research and Biology.2018; 16(6): 567.     CrossRef

Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refractory to negative pressure wound therapy, skin graft, or growth factors. Three injections of PDRN were administered at the wound site into the anterior and medial sides of the left stump on the 1st, 4th, and 9th days of hospitalization. The PDRN ameliorated wound healing by enhancing cell growth, tissue repair, and angiogenesis. PDRN application represents a potential treatment for non-healing wounds obviating the need for additional therapies, and hospitalization, as well as improve patient’s activities of daily living.

Citations

• An NIR-responsive hydrogel loaded with polydeoxyribonucleotide nano-vectors for enhanced chronic wound healing
  Yanzhen Sun, Yao Li, Xiaokang Ding, Pan Xu, Xiaodong Jing, Hailin Cong, Hao Hu, Bing Yu, Fu-Jian Xu
  Biomaterials.2025; 314: 122789.     CrossRef
• Non-surgical treatment of diabetic foot ulcers on the dorsum of the foot with polydeoxyribonucleotide injection: Two case reports
  Yooseok Ha, Jeong-Hee Kim, Jiyoung Kim, Hyeokjae Kwon
  World Journal of Clinical Cases.2024; 12(20): 4446.     CrossRef
• СУЧАСНІ МЕТОДИ ЛІКУВАННЯ РУБЦІВ ПІСЛЯ ЗАГОЄННЯ РАН, ОТРИМАНИХ ПІСЛЯ ВОГНЕПАЛЬНИХ ПОРАНЕНЬ І МІННО-ВИБУХОВИХ ТРАВМ РІЗНОГО ГЕНЕЗУ ТА ЛОКАЛІЗАЦІЇ У ВІЙСЬКОВИХ
  І. М. Салайда
  Здобутки клінічної і експериментальної медицини.2024; (2): 150.     CrossRef
• Analgesic Effect of Human Placenta Hydrolysate on CFA-Induced Inflammatory Pain in Mice
  Keun-Tae Park, Heejoon Jo, So-Hyun Jeon, Kyeongsoo Jeong, Minju Im, Jae-Won Kim, Jong-Pil Jung, Hoe Chang Jung, Jae hun Lee, Woojin Kim
  Pharmaceuticals.2024; 17(9): 1179.     CrossRef
• A chitosan derivative-crosslinked hydrogel with controllable release of polydeoxyribonucleotides for wound treatment
  Yanzhen Sun, Xiaodong Jing, Yang Liu, Bing Yu, Hao Hu, Hailin Cong, Youqing Shen
  Carbohydrate Polymers.2023; 300: 120298.     CrossRef
• Efficacy of Polydeoxyribonucleotide in Promoting the Healing of Diabetic Wounds in a Murine Model of Streptozotocin-Induced Diabetes: A Pilot Experiment
  Jiyoung Yun, SaeGwang Park, Ha Young Park, Kyung Ah Lee
  International Journal of Molecular Sciences.2023; 24(3): 1932.     CrossRef
• Rotator Cuff Tendon Regeneration
  Sang-Eun Park, Jong-Hun Ji, Hyun-Sik Jun
  Journal of the Korean Orthopaedic Association.2023; 58(5): 365.     CrossRef
• Topical Polydeoxyribonucleotide Loaded in Hydrogel Formulation for Wound Healing in Diabetic Rats
  Mariya Dmitriyeva, Timur Suleimenov, Daulet Yessenbayev, Dulat Turebayev, Saltanat Urazova, Mirsaid Izimbergenov, Saken Kozhakhmetov, Talgat Omarov, Medet Toleubayev
  Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 198.     CrossRef
• Current Progress and Outlook of Nano-Based Hydrogel Dressings for Wound Healing
  Xiao Zhang, Pengyu Wei, Zhengyang Yang, Yishan Liu, Kairui Yang, Yuhao Cheng, Hongwei Yao, Zhongtao Zhang
  Pharmaceutics.2022; 15(1): 68.     CrossRef
• Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering
  Tae-Hee Kim, Seong-Yeong Heo, Gun-Woo Oh, Soo-Jin Heo, Won-Kyo Jung
  Marine Drugs.2021; 19(6): 296.     CrossRef
• Alginate/chitosan-based hydrogel loaded with gene vectors to deliver polydeoxyribonucleotide for effective wound healing
  Xiaodong Jing, Yanzhen Sun, Yang Liu, Xiaoli Ma, Hao Hu
  Biomaterials Science.2021; 9(16): 5533.     CrossRef
• Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing
  Da Yong Shin, Ji-Ung Park, Min-Ha Choi, Sukwha Kim, Hyoun-Ee Kim, Seol-Ha Jeong
  Scientific Reports.2020;[Epub]     CrossRef
• The Effects of Polydeoxyribonucleotide on Wound Healing and Tissue Regeneration: A Systematic Review of the Literature
  Maria T Colangelo, Carlo Galli, Stefano Guizzardi
  Regenerative Medicine.2020; 15(6): 1801.     CrossRef

The application of three-dimensional (3D) printing is growing explosively in the medical field, and is especially widespread in the clinical use of fabricating upper limb orthosis and prosthesis. Advantages of 3D-printed orthosis compared to conventional ones include its lower cost, easier modification, and faster fabrication. Hands are the most common body parts involved with burn victims and one of the main complications of hand burns are finger joint contractures. Applying orthotic devices such as finger splints are a well-established essential element of burn care. In spite of the rapid evolution of the clinical use of 3D printing, to our knowledge, its application to hand burn patients has not yet been reported. In this study, the authors present a series of patients with hand burn injuries whose orthotic needs were fulfilled with the application of 3D-printed finger splints.

Citations

• Motion-Mimicking Robotic Finger Prosthesis for Burn-induced Partial Hand Amputee: A Case Report
  So Young Joo, Yoon Soo Cho, Jisu Seo, Yurim Seo, Sangho Yi, Cheong Hoon Seo
  Journal of Burn Care & Research.2025; 46(1): 230.     CrossRef
• A national survey of conservative mallet finger injury care and the potential for 3D printing to impact current practice
  Una M. Cronin, Dr. Niamh M. Cummins, Dr. Aidan O’ Sullivan, Prof. Damien Ryan, Prof. Leonard O'Sullivan
  Annals of 3D Printed Medicine.2025; 17: 100184.     CrossRef
• Response to Letter to the Editor “Motion-Mimicking Robotic Finger Prosthesis for Burn-Induced Partial Hand Amputee: A Case Report—Correspondence”
  So Young Joo, Yoon Soo Cho, Sangho Yi, Cheong Hoon Seo
  Journal of Burn Care & Research.2025;[Epub]     CrossRef
• 3D-printed orthoses vs. traditional plaster cast: a comparative clinical study
  Ciprian Glazer, Mihaela Oravitan, Corina Pantea, Alexandra Mihaela Stanila, Nicolae-Adrian Jurjiu, Andreea Totok, Mihai Petru Marghitas, Claudiu Avram
  Balneo and PRM Research Journal.2025; 16(Vol 16 No.): 785.     CrossRef
• Additive Manufacturing and Upper-Limb Orthoses: A Scoping Review
  Amy Gehner, Dianna Lunsford
  JPO Journal of Prosthetics and Orthotics.2024; 36(1): e25.     CrossRef
• An adjustable and customised finger splint to improve mallet finger treatment compliance and outcomes
  Shi Lei Teng, Yoke Rung Wong, Peggy Poh Hoon Lim, Duncan Angus McGrouther
  Annals of 3D Printed Medicine.2024; 13: 100142.     CrossRef
• Minimizing post-operative burn contracture through customized inter-phalangeal static stent: Analysis of digital vs conventional workflows - Case Report
  Shubham Sharma, Ritty Jeba E., Parag Dua, Saurav Kumar
  Journal of Indian Dental Association.2024;[Epub]     CrossRef
• A Review on 3D Scanners Studies for Producing Customized Orthoses
  Rui Silva, Bruna Silva, Cristiana Fernandes, Pedro Morouço, Nuno Alves, António Veloso
  Sensors.2024; 24(5): 1373.     CrossRef
• 3D printed personalized assistive devices: A material, technique, and medical condition perspective
  Srija Vennam, Vijayasankar KN, Falguni Pati
  Applied Materials Today.2024; 40: 102403.     CrossRef
• Effectiveness of hand reconstruction techniques for the treatment of postburn contractures of the hand: A systematic review
  Christos Vosinakis, Simona Ippoliti, Efthimios Samoladas, Anna-Bettina Haidich, Irene E. Gamatsi, Lee Smith, Chryssa Pourzitaki
  Burns.2024; 50(9): 107281.     CrossRef
• Utilization of 3D printed orthoses for musculoskeletal conditions of the upper extremity: A systematic review
  Deborah A. Schwartz, Katherine A. Schofield
  Journal of Hand Therapy.2023; 36(1): 166.     CrossRef
• Rehabilitation interventions after hand burn injury in adults: A systematic review
  Zoë Edger-Lacoursière, Erika Deziel, Bernadette Nedelec
  Burns.2023; 49(3): 516.     CrossRef
• Application of a 3D-Printed Writing–Typing Assistive Device in Patients with Cervical Spinal Cord Injury
  Ji Hwan Kim, Hee Seung Yang, Seung Hyun Han, Byung Min Lee, Youn Kyung Lee, Woo Sob Sim, Gwan Su Park, Seul Bin Na Lee, Min Jo
  Applied Sciences.2022; 12(18): 9037.     CrossRef
• Application of 3D Printing Technology in the Medical Field
  Bingwei Gao, Hongjian Zhao, Hongtao Yu, Yihan Lin, Jun Liu, Jiawei Wang
  Recent Advances in Electrical & Electronic Engineering (Formerly Recent Patents on Electrical & Electronic Engineering).2022; 15(8): 621.     CrossRef
• Manufacture and clinical application of the forearm pronation’s assistant tableware in the severely burned
  Jia-Jia Shi, Ying Sun, Shan-Shan Pan, Ting-Ting Xu, Jia-Jia Hua
  Burns.2021; 47(3): 684.     CrossRef
• In-hospital professional production of patient-specific 3D-printed devices for hand and wrist rehabilitation
  M. Keller, A. Guebeli, Florian Thieringer, Philipp Honigmann
  Hand Surgery and Rehabilitation.2021; 40(2): 126.     CrossRef
• Direct 3D Printing of a hand splint using Reverse Engineering
  J Kechagias, K Kitsakis, A Zacharias, K Theocharis, K-E Aslani, M Petousis, N A Fountas, N M Vaxevadnidis
  IOP Conference Series: Materials Science and Engineering.2021; 1037(1): 012019.     CrossRef
• Three-dimensional Printed Customized Adjustable Mallet Finger Splint: A Cheap, Effective, and Comfortable Alternative
  Theodora Papavasiliou, Rushabh K. Shah, Stelios Chatzimichail, Lauren Uppal, Jeffrey C.Y. Chan
  Plastic and Reconstructive Surgery - Global Open.2021; 9(3): e3500.     CrossRef
• Overview of In‐Hospital 3D Printing and Practical Applications in Hand Surgery
  Marco Keller, Alissa Guebeli, Florian Thieringer, Philipp Honigmann, Xiaojun Duan
  BioMed Research International.2021;[Epub]     CrossRef
• Clinical Utility of an Exoskeleton Robot Using Three-Dimensional Scanner Modeling in Burn Patient: A Case Report
  So Young Joo, Seung Yeol Lee, Yoon Soo Cho, Sangho Yi, Cheong Hoon Seo
  Journal of Burn Care & Research.2021; 42(5): 1030.     CrossRef
• Customized Power Wheelchair Joysticks Made by Three-Dimensional Printing Technology: A Pilot Study on the Environmental Adaptation Effects for Severe Quadriplegia
  Hee Dong Shin, Da Hyun Ahn, Hyun Ah Lee, Yun Kyung Lee, Hee Seung Yang, Min Jo, Seul Bin Na Lee, Gwan Su Park, Yun Sub Hwang, Woo Sob Sim, Sung-Jun Park
  International Journal of Environmental Research and Public Health.2021; 18(14): 7464.     CrossRef
• Effectiveness of 3D-printed orthoses for traumatic and chronic hand conditions: A scoping review
  T. A. M. Oud, E. Lazzari, H. J. H. Gijsbers, M. Gobbo, F. Nollet, M. A. Brehm, David Benjamin Lumenta
  PLOS ONE.2021; 16(11): e0260271.     CrossRef
• Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges
  Alina Ghilan, Aurica P. Chiriac, Loredana E. Nita, Alina G. Rusu, Iordana Neamtu, Vlad Mihai Chiriac
  Journal of Polymers and the Environment.2020; 28(5): 1345.     CrossRef
• The functional effect of 3D-printing individualized orthosis for patients with peripheral nerve injuries
  Dong-Sik Chae, Da-Ham Kim, Kyung-Yil Kang, Doo-Young Kim, Si-Woon Park, Sung-Jun Park, Jae-Hyung Kim
  Medicine.2020; 99(16): e19791.     CrossRef
• 3D printing technologies in the treatment of patients with injuries and diseases of the forearm and hand
  V V Khominets, S A Peleshok, D A Volov, M V Titova, M I Eliseeva, S V Kushnarev, A V Shirshin, V N Adamenko, Ya I Nebylitsa
  Bulletin of the Russian Military Medical Academy.2020; 22(1): 113.     CrossRef
• 3D printing in hand surgery
  V. Matter-Parrat, P. Liverneaux
  Hand Surgery and Rehabilitation.2019; 38(6): 338.     CrossRef

Citations

• Effect of repetitive transcranial magnetic stimulation on the ascending reticular activating system in a patient with disorder of consciousness: a case report
  Sung Ho Jang, Young Hyeon Kwon
  BMC Neurology.2020;[Epub]     CrossRef