Objective
To demonstrate the utility of Scale for the Assessment and Rating of Ataxia (SARA) for evaluation of posterior circulation-related features in patients with mild stroke.
Methods
Forty-five subjects, diagnosed with acute infarction in the cerebellum, basis pontis, thalamus, corona radiata, posterior limb of internal capsule, and their National Institutes of Health Stroke Scale (NIHSS) scores ≤5 were enrolled. SARA scores were graded by the cut-off value of severity in dependency of activities of daily living (ADL). SARA, Berg Balance Scale (BBS), Timed Up-and-Go (TUG), and Trunk Control Test (TCT) were correlated in regression analysis with the modified Rankin Scale (mRS) at discharge. Correlation between SARA and other tools was analyzed. Patients were divided based on mRS at admission (group A, mRS 0–2; group B, mRS 3–5). Scores between the two groups were compared.
Results
Among the subjects, 48.9% (22/45) scored above 5.5 on SARA, and even 11.1% (5/45) scored higher than 14.25, which is the cut-off value of ‘severe dependency’ in ADL. SARA showed significant value for prediction of mRS at discharge. SARA was correlated with BBS (r=-0.946, p<0.001), TUG (r=-0.584, p<0.001), and TCT (r=-0.799, p<0.001). The SARA, BBS, TUG, and TCT scores between were lower in group B than in group A patients. SARA as well as BBS, TUG, and TCT reflect the functional severity of all patients.
Conclusion
SARA is a complementary tool for evaluation of the severity of ataxia in mild stroke patients with features of posterior circulation.

Citations

• Quantum Computing in the Realm of Neurosurgery
  Ali A. Mohamed, Emma Sargent, Camberly Moriconi, Cooper Williams, Syed Maaz Shah, Brandon Lucke-Wold
  World Neurosurgery.2025; 193: 8.     CrossRef
• Frequency, phenotypes, and neuroimaging of early post stroke movement disorders: a prospective study
  Eslam Samra, Tamer Roushdy, Amr S. Zaki, Alia H. Mansour, Ahmed Elbassiouny, Ali Shalash
  The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2025;[Epub]     CrossRef
• Validation of the Italian Version of the Scale for the Assessment and Rating of Ataxia (SARA) in Multiple Sclerosis: A Cross-Sectional Study
  Giovanni Sellitto, Serena D’Aniello, Emanuele Amadio, Francescaroberta Panuccio, Andrea Marini Padovani, Rachele Simeon, Anna Berardi, Giovanni Galeoto, Ilaria Ruotolo
  The Cerebellum.2025;[Epub]     CrossRef
• Scale for the assessment and rating of ataxia (SARA): Übersetzung und kulturelle Anpassung an den deutschsprachigen Raum
  Julia Silberbauer, Sonja Schidl, Gudrun Diermayr, Tanja Schmitz-Hübsch, Andrea Greisberger
  Wiener Medizinische Wochenschrift.2024; 174(5-6): 111.     CrossRef
• Ataxic hemiparesis: a narrative review for clinical practice in rehabilitation
  Mei-Fen Sung, Jeong Hoon Lim
  Topics in Stroke Rehabilitation.2024; 31(5): 537.     CrossRef
• Effects of Non‐Invasive Brain Stimulation for Degenerative Cerebellar Ataxia: A Systematic Review and Meta‐Analysis
  Akiyoshi Matsugi, Hiroyuki Ohtsuka, Kyota Bando, Yuki Kondo, Yutaka Kikuchi
  Movement Disorders Clinical Practice.2024; 11(11): 1323.     CrossRef
• Recovery of walking ability in stroke patients through postacute care rehabilitation
  Chan-Lin Chu, Tsong-Hai Lee, Yueh-Peng Chen, Long-Sun Ro, Jung-Lung Hsu, Yu-Cheng Chu, Chih-Kuang Chen, Yu-Cheng Pei
  Biomedical Journal.2023; 46(4): 100550.     CrossRef
• Cognition assessments to predict inpatient falls in a subacute stroke rehabilitation setting
  Alejandro García-Rudolph, Alberto García-Molina, Eloy Opisso, Josep María Tormos, Montserrat Bernabeu
  Topics in Stroke Rehabilitation.2021; 28(1): 52.     CrossRef
• Assessment of Ataxia Rating Scales and Cerebellar Functional Tests: Critique and Recommendations
  Santiago Perez‐Lloret, Bart van de Warrenburg, Malco Rossi, Carmen Rodríguez‐Blázquez, Theresa Zesiewicz, Jonas A.M. Saute, Alexandra Durr, Masatoyo Nishizawa, Pablo Martinez‐Martin, Glenn T. Stebbins, Anette Schrag, Matej Skorvanek
  Movement Disorders.2021; 36(2): 283.     CrossRef
• Predictive Validity of the Scale for the Assessment and Rating of Ataxia for Medium-Term Functional Status in Acute Ataxic Stroke
  Kota Yamauchi, Kenichi Kumagae, Kei Goto, Risa Hagiwara, Yoshiko Uchida, Eisei Harayama, Shota Tanaka, Sota Kuroyama, Yasuhiro Koyanagi, Shuji Arakawa
  Journal of Stroke and Cerebrovascular Diseases.2021; 30(4): 105631.     CrossRef
• The impact of Body Mass Index on functional rehabilitation outcomes of working-age inpatients with stroke
  Alejandro GARCÍA-RUDOLPH, John D. KELLEHER, Blanca CEGARRA, Joan SAURÍ RUIZ, Vasudevan NEDUMPOZHIMANA, Eloy OPISSO, Josep M. TORMOS, Montserrat BERNABEU
  European Journal of Physical and Rehabilitation Medicine.2021;[Epub]     CrossRef
• Functional Disability After Ischemic Stroke: A Community-Based Cross-Sectional Study in Shanghai, China
  Ying-Ye Yao, Zi-Jun Wei, Yue-Chan Zhang, Xiang Li, Liu Gong, Jia-Wei Zhou, Yu Wang, Yun-Yun Zhang, Rui-Ping Wang
  Frontiers in Neurology.2021;[Epub]     CrossRef
• Role of Cortico-ponto-cerebellar Tract from Supplementary Motor Area in Ataxic Hemiparesis of Supratentorial Stroke Patients
  Nayeon Ko, Hyun Haeng Lee, Kyungmin Kim, Bo-Ram Kim, Won-Jin Moon, Jongmin Lee
  Brain & Neurorehabilitation.2021;[Epub]     CrossRef
• Novel Insights Toward Human Stroke-Related Epigenetics: Circular RNA and its Impact in Poststroke Processes
  Pablo W Silva, Samara M M Shimon, Leonardo M de Brito, Laís Reis-das-Mercês, Leandro Magalhães, Gilderlanio Araújo, Ândrea Ribeiro-dos-Santos, Amanda F Vidal
  Epigenomics.2020; 12(22): 1957.     CrossRef

Objective
To determine the possibility of a new measurement tool using electromyography and ultrasonography for quantitative spasticity assessment in post-stroke patients.
Methods
Eight hemiplegic stroke patients with ankle plantarflexor spasticity confirmed by a Modified Ashworth Scale (MAS) were enrolled. Spasticity was evaluated using the MAS and Modified Tardieu Scale (MTS). Each subject underwent surface electromyography (sEMG) using the Brain Motor Control Assessment (BMCA) protocol and was compared with a healthy control group. Using ultrasonography, muscle architecture and elasticity index were measured from the medial gastrocnemius muscle (GCM) on the affected and unaffected sides.
Results
MAS and MTS revealed significant correlation with sEMG activity. The fascicle length and pennation angle were significantly decreased in the medial GCM on the hemiplegic side compared with the unaffected side. The elasticity index of the spastic medial GCM was significantly increased compared with the unaffected side. The MTS X and R2–R1 values were significantly correlated with the elasticity index in the hemiplegic GCM. The relationship between clinical evaluation tools and both BMCA and sonoelastography was linear, but not statistically significant in the multiple regression analysis.
Conclusion
The BMCA protocol and ultrasonographic evaluation provide objective assessment of post-stroke spasticity. Further studies are necessary to conduct accurate assessment and treatment of spasticity.

Citations

• Feasibility of shear wave elastography to assess upper limb spasticity in patients after brain injury
  Ganglin Chen, Ling Ren, Zhenguo Wu, Xianrui Hu, Jing He
  Disability and Rehabilitation.2025; : 1.     CrossRef
• Shear wave elastography in the assessment of gastrocnemius spastic muscle elasticity: influences of ankle position and muscle contraction
  Marine DEVIS, Frédéric LECOUVET, Thierry LEJEUNE, Gaëtan STOQUART
  European Journal of Physical and Rehabilitation Medicine.2025;[Epub]     CrossRef
• Conformal, stretchable, breathable, wireless epidermal surface electromyography sensor system for hand gesture recognition and rehabilitation of stroke hand function
  Kerong Yang, Senhao Zhang, Ying Yang, Xiaoman Liu, Jiuqiang Li, Benkun Bao, Chang Liu, Hongbo Yang, Kai Guo, Huanyu Cheng
  Materials & Design.2024; 243: 113029.     CrossRef
• Assessing muscle architecture with ultrasound: implications for spasticity
  Ève Boissonnault, April Hyon, Michael C. Munin, Mirko Filippetti, Alessandro Picelli, Chloe Haldane, Rajiv Reebye
  European Journal of Translational Myology.2024;[Epub]     CrossRef
• Comparative study on muscle-tendon stiffness and balance impairment in postmenopausal women: a focus on osteosarcopenia and osteoporosis
  Elham Bagheri Yekta, Giti Torkaman, Leila Aghaghazvini
  Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
• Examination of evaluation indicators for spasticity in stroke patients using ultrasound imaging equipment
  Takahiro Okazaki, Shota Nagai
  Journal of Physical Therapy Science.2024; 36(12): 776.     CrossRef
• Utility of Ultrasound Elastography to Evaluate Poststroke Spasticity and Therapeutic Efficacy: A Narrative Review
  Meng-Ting Lin, Shu-Mei Yang, Hao-Wei Wu, Yen-Hua Chen, Chueh-Hung Wu
  Journal of Medical Ultrasound.2023; 31(3): 171.     CrossRef
• Ultrasound elastography in the assessment of post-stroke muscle stiffness: a systematic review
  Jacqueline Roots, Gabriel S Trajano, Davide Fontanarosa
  Insights into Imaging.2022;[Epub]     CrossRef
• Technology-assisted assessment of spasticity: a systematic review
  Xinliang Guo, Rebecca Wallace, Ying Tan, Denny Oetomo, Marlena Klaic, Vincent Crocher
  Journal of NeuroEngineering and Rehabilitation.2022;[Epub]     CrossRef
• Ultrasound Elastography in the Assessment of the Stiffness of Spastic Muscles: A Systematic Review
  Laura Daniela Ordierez Zúñiga, Carlos Alberto Gaviria López, Elizabeth Roldán González
  Ultrasound in Medicine & Biology.2021; 47(6): 1448.     CrossRef
• Using Surface Electromyography to Evaluate the Efficacy of Governor Vessel Electroacupuncture in Poststroke Lower Limb Spasticity: Study Protocol for a Randomized Controlled Parallel Trial
  Jingwen Li, Kaiqi Su, Jinjin Mei, Yiying Wang, Shuai Yin, Yanchao Hu, Wenxue Hao, Xiaodong Feng, Ruiqing Li, Hongcai Shang
  Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1.     CrossRef
• Muscle and tendon properties of the spastic lower leg after stroke defined by ultrasonography: a systematic review
  Fabienne SCHILLEBEECKX, An DE GROEF, Nathalie DE BEUKELAER, Kaat DESLOOVERE, Geert VERHEYDEN, Koen PEERS
  European Journal of Physical and Rehabilitation Medicine.2021;[Epub]     CrossRef
• Soft Rehabilitation Actuator With Integrated Post-stroke Finger Spasticity Evaluation
  Ho Lam Heung, Zhi Qiang Tang, Xiang Qian Shi, Kai Yu Tong, Zheng Li
  Frontiers in Bioengineering and Biotechnology.2020;[Epub]     CrossRef
• A domestic robotic rehabilitation device for assessment of wrist function for outpatients
  Matthias Panny, Andreas Mayr, Marco Nagiller, Yeongmi Kim
  Journal of Rehabilitation and Assistive Technologies Engineering.2020;[Epub]     CrossRef

Objective
To explore plastic changes in the red nucleus (RN) of stroke patients with severe corticospinal tract (CST) injury as a compensatory mechanism for recovery of hand function.
Methods
The moderate group (MG) comprised 5 patients with synergistic hand grasp movement combined with limited extension, and the severe group (SG) included 5 patients with synergistic hand grasp movement alone. The control group (CG) included 5 healthy subjects. Motor assessment was measured by Motricity Index (MI). Diffusion tensor imaging was analyzed using fractional anisotropy (FA) and radial diffusivity (RD) in the individual regions of interest (ROIs)—bilateral internal capsule and anterior pons for CST injury and bilateral RN for rubrospinal tract (RST) injury.
Results
The SG showed a significantly lower MI score than the MG mainly due to differences in hand subscores. Significantly reduced FA was observed in both MG and SG compared with CG, while SG showed increased MD and RD in the affected ROIs of CST, and increased FA on the unaffected side compared with CG. However, in the RN ROI, a significantly increased FA and decreased RD on the unaffected side similar to the affected side were found only in the SG. The relative index of FA was lower and RD in SG was higher than in CG in RST.
Conclusion
The diffusion metrics of RST showed changes in patients with severe CST injury, suggesting that RST may play a role in the recovery of hand function in patients with severe CST injury.

Citations

• Insights into the dependence of post-stroke motor recovery on the initial corticospinal tract connectivity from a computational model
  Dongwon Kim, Leah M. O’Shea, Naveed R. Aghamohammadi
  Journal of NeuroEngineering and Rehabilitation.2025;[Epub]     CrossRef
• Constraint‐Induced Movement Therapy Promotes Contralesional Red Nucleus Plasticity and Increases Bilateral Motor Cortex‐to‐Red Nucleus Projections After a Large‐Area Stroke
  Peile Liu, Jian Hu, Beiyao Gao, Yan Hua, Ying Xing, Yulong Bai, Nan Liu, Yuen Gao
  Behavioural Neurology.2025;[Epub]     CrossRef
• Compensatory Hyperactivity of the Ipsilesional Red Nucleus in a Patient With Somatosensory Cortex Damage: A Case Report
  Jeongeun Lee, Eunjee Lee, Shahid Bashir, Gyu Jin Kim, Suk Hoon Ohn, Kwang-Ik Jung, Woo-Kyoung Yoo
  Brain & Neurorehabilitation.2023;[Epub]     CrossRef
• Microstructure and Genetic Polymorphisms: Role in Motor Rehabilitation After Subcortical Stroke
  Jingchun Liu, Caihong Wang
  Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
• Immediate and short-term effects of continuous theta burst transcranial magnetic stimulation over contralesional premotor area on post-stroke spasticity in patients with severe hemiplegia: Study protocol for a randomized controlled trial
  Xiupan Wei, Nan Xia, Yang-An Li, Minghui Gu, Tongming Zhang, Wei Gao, Yali Liu
  Frontiers in Neurology.2022;[Epub]     CrossRef
• Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery
  Zhengrun Gao, Zhen Pang, Yiming Chen, Gaowei Lei, Shuai Zhu, Guotao Li, Yundong Shen, Wendong Xu
  Neuroscience Bulletin.2022; 38(12): 1569.     CrossRef
• Red nucleus structure and function: from anatomy to clinical neurosciences
  Gianpaolo Antonio Basile, Marina Quartu, Salvatore Bertino, Maria Pina Serra, Marianna Boi, Alessia Bramanti, Giuseppe Pio Anastasi, Demetrio Milardi, Alberto Cacciola
  Brain Structure and Function.2021; 226(1): 69.     CrossRef
• Is there a doctor on the plane? A review of in-flight emergencies for the on-board radiologist
  Jason D. Vadhan, Karuna M. Raj, Sean D. Raj
  Clinical Imaging.2021; 76: 265.     CrossRef
• Corticospinal vs Rubrospinal Revisited: An Evolutionary Perspective for Sensorimotor Integration
  Rafael Olivares-Moreno, Paola Rodriguez-Moreno, Veronica Lopez-Virgen, Martín Macías, Moisés Altamira-Camacho, Gerardo Rojas-Piloni
  Frontiers in Neuroscience.2021;[Epub]     CrossRef
• Upper and Lower Limb Motor Function Correlates with Ipsilesional Corticospinal Tract and Red Nucleus Structural Integrity in Chronic Stroke: A Cross-Sectional, ROI-Based MRI Study
  Denise M. Peters, Julius Fridriksson, Jessica D. Richardson, Jill C. Stewart, Chris Rorden, Leonardo Bonilha, Addie Middleton, Stacy L. Fritz, Nicola Tambasco
  Behavioural Neurology.2021; 2021: 1.     CrossRef
• Role of Cortico-ponto-cerebellar Tract from Supplementary Motor Area in Ataxic Hemiparesis of Supratentorial Stroke Patients
  Nayeon Ko, Hyun Haeng Lee, Kyungmin Kim, Bo-Ram Kim, Won-Jin Moon, Jongmin Lee
  Brain & Neurorehabilitation.2021;[Epub]     CrossRef
• Denoise magnitude diffusion magnetic resonance images via variance-stabilizing transformation and optimal singular-value manipulation
  Xiaodong Ma, Kâmil Uğurbil, Xiaoping Wu
  NeuroImage.2020; 215: 116852.     CrossRef
• A Review of Exercise-Induced Neuroplasticity in Ischemic Stroke: Pathology and Mechanisms
  Ying Xing, Yulong Bai
  Molecular Neurobiology.2020; 57(10): 4218.     CrossRef
• Rudimentary Dexterity Corresponds With Reduced Ability to Move in Synergy After Stroke: Evidence of Competition Between Corticoreticulospinal and Corticospinal Tracts?
  Merav R. Senesh, Karina Barragan, David J. Reinkensmeyer
  Neurorehabilitation and Neural Repair.2020; 34(10): 904.     CrossRef
• Intact microstructure of the right corticostriatal pathway predicts creative ability in healthy adults
  Farzaneh Rahmani, Hossein Sanjari Moghaddam, Mohammad Hadi Aarabi
  Brain and Behavior.2020;[Epub]     CrossRef
• The cortico-rubral and cerebello-rubral pathways are topographically organized within the human red nucleus
  Alberto Cacciola, Demetrio Milardi, Gianpaolo Antonio Basile, Salvatore Bertino, Alessandro Calamuneri, Gaetana Chillemi, Giuseppe Paladina, Federica Impellizzeri, Fabio Trimarchi, Giuseppe Anastasi, Alessia Bramanti, Giuseppina Rizzo
  Scientific Reports.2019;[Epub]     CrossRef
• Differential involvement of rubral branches in chronic capsular and pontine stroke
  Jun Guo, Jingchun Liu, Caihong Wang, Chen Cao, Lejun Fu, Tong Han, Jingliang Cheng, Chunshui Yu, Wen Qin
  NeuroImage: Clinical.2019; 24: 102090.     CrossRef

Objective
To assess the efficacy and safety of our 4-week caregiver-mediated exercise (CME) in improving trunk control capacity, gait, and balance and in decreasing concerns about post-stroke falls when there is an increase in its efficacy.
Methods
Acute or subacute stroke survivors were assigned to either the trial group (n=35) or the control group (n=37). Changes in Modified Barthel Index (MBI), Functional Ambulation Categories (FAC), Berg Balance Scale (BBS), and Trunk Impairment Scale (TIS) scores at 4 weeks from baseline served as primary outcome measures. Correlations of primary outcome measures with changes in Fall Efficacy Scale-International (FES-I) scores at 4 weeks from baseline in the trial group served as secondary outcome measures. Treatment-emergent adverse events (TEAEs) served as safety outcome measures.
Results
There were significant differences in changes in MBI, FAC, BBS, TIS-T, TIS-D, TIS-C, and FES-I scores at 4 weeks from baseline between the two groups (all p<0.0001). There were no significant (p=0.0755) differences in changes in TIS-S scores at 4 weeks from baseline between the two groups. MBI, FAC, BBS, and TIS scores showed significantly inverse correlations with FES-I scores in patients receiving CME. There were no TEAEs in our series.
Conclusion
CME was effective and safe in improving the degree of independence, ambulation status, dynamic and static balance, trunk function, and concerns about post-stroke falls in stroke survivors.

Citations

• Physical rehabilitation approaches for the recovery of function and mobility following stroke
  Alex Todhunter-Brown, Ceri E Sellers, Gillian D Baer, Pei Ling Choo, Julie Cowie, Joshua D Cheyne, Peter Langhorne, Julie Brown, Jacqui Morris, Pauline Campbell
  Cochrane Database of Systematic Reviews.2025;[Epub]     CrossRef
• Effects of Real-Time Feedback Methods on Static Balance Training in Stroke Patients: A Randomized Controlled Trial
  Il-Ho Kwon, Won-Seob Shin, Kyu-Seong Choi, Myung-Sun Lee
  Healthcare.2024; 12(7): 767.     CrossRef
• Impact of telehealth on stroke survivor–caregiver dyad in at‐home rehabilitation: A systematic review
  Davide Bartoli, Antonello Petrizzo, Ercole Vellone, Rosaria Alvaro, Gianluca Pucciarelli
  Journal of Advanced Nursing.2024; 80(10): 4003.     CrossRef
• Stroke survivor and caregiver experiences of virtual reality gaming to promote social participation: A qualitative study
  Suzanne Hoi Shan Lo, Janita Pak Chun Chau, Kai Chow Choi, Laveeza Butt, Alexander Yuk Lun Lau, Vivian Wing Yan Lee, Eddie Chi Fai Kwok, David R. Thompson, Nadinne Alexandra Roman
  PLOS ONE.2024; 19(12): e0315826.     CrossRef
• Physical activity according to sit-to-stand, standing, and stand-to-sit abilities in subacute stroke with walking difficulty: a cross-sectional study
  Natsuki Shimizu, Hiroyuki Hashidate, Tomohiro Ota, Yumi Kawai
  Physiotherapy Theory and Practice.2023; 39(11): 2327.     CrossRef
• Anosognosia for Hemiplegia and Falls After Stroke
  Elizabeth M. Byrd, Christianne E. Strang, Xiaofei Qiao, Lori Loan, Rebecca S. Miltner, Rita A. Jablonski
  Rehabilitation Nursing.2023; 48(1): 14.     CrossRef
• Effectiveness of caregiver‐mediated exercise interventions on activities of daily living, anxiety and depression post‐stroke rehabilitation: A systematic review and meta‐analysis
  Wen Ting Choo, Ying Jiang, Kendy Gui Fang Chan, Hadassah Joann Ramachandran, Jun Yi Claire Teo, Chuen Wei Alvin Seah, Wenru Wang
  Journal of Advanced Nursing.2022; 78(7): 1870.     CrossRef
• Exercise participation and promotion in the multiple sclerosis community; perspectives across varying socio-ecological levels
  Yvonne C. Learmonth, Zita Chan, Helen Correia, Dave Hathorn, Allan Kermode, Catherine Smith, Diana Walker
  Disability and Rehabilitation.2021; 43(25): 3623.     CrossRef
• Continuity of Care During COVID-19 Lockdown: A Survey on Stakeholders' Experience With Telerehabilitation
  Carla Assenza, Hilenia Catania, Clementina Antenore, Tiziana Gobbetti, Paola Gentili, Stefano Paolucci, Daniela Morelli
  Frontiers in Neurology.2021;[Epub]     CrossRef
• The effects of virtual reality augmented robot-assisted gait training on dual-task performance and functional measures in chronic stroke: a randomized controlled single-blind trial
  Büşra KAYABINAR, İpek ALEMDAROĞLU-GÜRBÜZ, Öznur YILMAZ
  European Journal of Physical and Rehabilitation Medicine.2021;[Epub]     CrossRef
• Physical fitness training for stroke patients
  David H Saunders, Mark Sanderson, Sara Hayes, Liam Johnson, Sharon Kramer, Daniel D Carter, Hannah Jarvis, Miriam Brazzelli, Gillian E Mead
  Cochrane Database of Systematic Reviews.2020;[Epub]     CrossRef
• Developing ActivABLES for community-dwelling stroke survivors using the Medical Research Council framework for complex interventions
  Steinunn A. Olafsdottir, Helga Jonsdottir, Charlotte Magnusson, Héctor Caltenco, Mikko Kytö, Laura Maye, David McGookin, Ingibjörg Bjartmarz, Solveig Asa Arnadottir, Ingibjörg Hjaltadottir, Thora B. Hafsteinsdottir
  BMC Health Services Research.2020;[Epub]     CrossRef
• Feasibility of ActivABLES to promote home-based exercise and physical activity of community-dwelling stroke survivors with support from caregivers: A mixed methods study
  Steinunn A. Olafsdottir, Helga Jonsdottir, Ingibjörg Bjartmarz, Charlotte Magnusson, Héctor Caltenco, Mikko Kytö, Laura Maye, David McGookin, Solveig Asa Arnadottir, Ingibjörg Hjaltadottir, Thora B. Hafsteinsdottir
  BMC Health Services Research.2020;[Epub]     CrossRef
• The effects of sitting Tai Chi on physical and psychosocial health outcomes among individuals with impaired physical mobility
  Jie Zhao, Janita Pak Chun Chau, Yuli Zang, Suzanne Hoi Shan Lo, Kai Chow Choi, Surui Liang
  Medicine.2020; 99(34): e21805.     CrossRef

Objective
To investigate the differences in hyolaryngeal kinematics at rest and during swallowing in the upright sitting (UP) and the lateral decubitus (LD) postures in healthy adults, and delineating any potential advantages of swallowing while in the LD posture.
Methods
Swallowing was videofluoroscopically evaluated in 20 healthy volunteers in UP and LD postures, based on the movements of hyoid bone, vocal folds, and the bolus head. Parameters included the Penetration-Aspiration Scale (PAS), horizontal and vertical displacement, horizontal and vertical initial position, horizontal and vertical peak position, time to peak position of the hyoid bone and vocal folds, and pharyngeal transit time (PTT).
Results
Nine participants were rated PAS 2 in the UP and 1 was rated PAS 2 in the LD (p=0.003) at least 1 out of 3 swallows each posture. The hyoid and vocal folds showed more anterior and superior peak and initial positions in the LD. In addition, swallowing resulted in greater vertical and smaller horizontal displacement of the hyoid in LD posture compared with UP. Time to peak position of the hyoid was shorter in LD. The maximal vertical and horizontal displacement of the vocal folds, and PTT were comparable between postures.
Conclusion
The results showed that the peak and initial positions of the hyoid and larynx and the pattern of hyoid movement varied significantly depending on the body postures. This study suggests that the LD posture was one of the safe feeding postures without any increased risk compared with UP posture.

Citations

• Location of the upper oesophageal sphincter during swallowing: Analysis using swallowing CT
  Minxing Gao, Yoko Inamoto, Eiichi Saitoh, Keiko Aihara, Seiko Shibata, Marlis Gonzalez‐Fernandez, Yohei Otaka
  Journal of Oral Rehabilitation.2024; 51(7): 1193.     CrossRef
• Successful Continuation of Oral Intake in a Dysphagic and Tetraplegic Patient With Alternate Right and Left Complete Lateral Decubitus Positions in Rehabilitation
  Yoshinori Maki, Mayumi Takagawa, Akio Goda, Junichi Katsura, Ken Yanagibashi
  Cureus.2023;[Epub]     CrossRef
• Subjective and objective evaluation of swallowing in lateral decubitus positions examined in healthy volunteers
  Mayumi Takagawa, Akio Goda, Yoshinori Maki, Ryota Ishibashi, Takumi Morita, Junichi Katsura, Ken Yanagibashi
  European Archives of Oto-Rhino-Laryngology.2022; 279(2): 1071.     CrossRef
• How a personalised transportable folding device for seating impacts dysphagia
  Virginie Woisard, Mireille Costes, Hélène Colineaux, Benoit Lepage
  European Archives of Oto-Rhino-Laryngology.2020; 277(1): 179.     CrossRef
• Online Learning for the Hyoid Bone Tracking During Swallowing With Neck Movement Adjustment Using Semantic Segmentation
  Dongheon Lee, Woo Hyung Lee, Han Gil Seo, Byung-Mo Oh, Jung Chan Lee, Hee Chan Kim
  IEEE Access.2020; 8: 157451.     CrossRef
• Proportion of Aspiration Pneumonia Cases Among Patients With Community-Acquired Pneumonia: A Single-Center Study in Korea
  Inpyo Jeon, Gwang Pyo Jung, Han Gil Seo, Ju Seok Ryu, Tai Ryoon Han, Byung-Mo Oh
  Annals of Rehabilitation Medicine.2019; 43(2): 121.     CrossRef

Objective
To identify the relationship between maximum phonation time (MPT) and swallowing function, as well as the elements of swallowing, in order to provide a rationale for speech therapy in patients with Parkinsonism manifesting dysphagia.
Methods
Thirty patients with Parkinsonism who underwent speech evaluation and videofluoroscopic swallowing study (VFSS) were recruited. The MPT, the longest periods of sustained pronunciation of /aa/, was evaluated. The VFSS was evaluated using Penetration Aspiration Scale (PAS), National Institutes of Health-Swallowing Safety Scale (NIH-SSS), and Videofluoroscopic Dysphagia Scale (VDS). The relationship between dysphagia scales and MPT was analyzed using Pearson correlation. The difference in VDS variables between subgroups (Parkinson disease or Parkinsonian syndrome, independent or dependent ambulation, and normal or abnormal MPT) and the difference in MPT between subgroups based on the VDS variables were analyzed using the independent t-test.
Results
Bolus formation and laryngeal elevation functions were significantly higher in the normal MPT group compared with the impaired group. In the VDS variables, patients with intact bolus formation, oral transit time, pharyngeal swallow triggering, and laryngeal elevation showed significantly longer MPTs compared with the impaired groups. In addition, MPT was significantly correlated with the VDS and modestly correlated with the NIH-SSS, but not the PAS, suggesting that phonatory function is related to the oropharyngeal swallowing function, but not directly to the aspiration itself.
Conclusion
The correlation between MPT and several swallowing-related elements was identified, indicating an interactive correlation between swallowing and phonation. This result justifies voice therapy as a treatment for dysphagia in patients with Parkinsonism.

Citations

• Correlation between voice intensity and swallowing function in subjects with Parkinson’s disease
  Cinzia Baldanzi, Valeria Crispiatico, Giulia Fusari, Francesca Lea Saibene, Pietro Arcuri, Mario Meloni, Davide Cattaneo, Chiara Vitali
  Neurological Sciences.2025; 46(2): 713.     CrossRef
• Voice Meets Swallowing: A Scoping Review of Therapeutic Connections
  Adrián Castillo-Allendes, Jeff Searl, José Vergara, Natalie Ballentine, Soud Ebdah, Anaïs Rameau, Eric J. Hunter
  American Journal of Speech-Language Pathology.2025; 34(2): 877.     CrossRef
• Effect of voice training intervention on swallowing function in patients with head and neck cancer undergoing radiotherapy: A randomized controlled trial
  Yan Liu, Ran Hou, Qinqin Yu, Qiaohong Niu
  European Journal of Oncology Nursing.2024; 70: 102551.     CrossRef
• Therapeutic singing-induced swallowing exercise for dysphagia in advanced-stage Parkinson’s disease
  Myung Sun Yeo, Jihye Hwang, Hye Kyoung Lee, Soo Ji Kim, Sung-Rae Cho
  Frontiers in Neurology.2024;[Epub]     CrossRef
• Changes in and clinical utility of maximum phonation time and repetitive saliva swallowing test scores after esophagectomy
  Suguru Maruyama, Yoshihiko Kawaguchi, Kyoko Nitta, Hidenori Akaike, Katsutoshi Shoda, Yudai Higuchi, Takashi Nakayama, Ryo Saito, Wataru Izumo, Koichi Takiguchi, Kensuke Shiraishi, Shinji Furuya, Yuki Nakata, Hidetake Amemiya, Hiromichi Kawaida, Daisuke I
  Esophagus.2024; 21(3): 348.     CrossRef
• Post-Extubated Dysphagia in Intensive Care Unit Patients Based on Flexible Endoscopic Evaluation of Swallowing Examination and Its Affecting Factors
  Indira Sari, Susyana Tamin, Elvie Zulka Kautzia Rachmawati, Syahrial M. Hutauruk, Fauziah Fardizza, Dita Aditianingsih, Joedo Prihartono
  Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2024; 67(7): 394.     CrossRef
• The Study of Speech Acoustic Characteristics of Elderly Individuals with Presbyphagia in Ningbo, China
  YuHan He, XiaoYu Wang, TianYi Huang, WenSheng Zhao, Zhen Fu, Qin Zheng, LingJing Jin, HaKyung Kim, HengXin Liu
  Journal of Voice.2024;[Epub]     CrossRef
• Adhesion Reduction Agent Guardix-SG® Versus MegaShield® for Postoperative Swallowing Function Analysis in Thyroidectomy Patients
  Hye Kyoung Lee, Jihye Hwang, Seongmoon Jo, Jin Kyong Kim, Cho Rok Lee, Sang-Wook Kang, Kee-Hyun Nam, Sung-Rae Cho
  Clinical Medicine Insights: Oncology.2024;[Epub]     CrossRef
• Effect of Spinal Sagittal Alignment in Sitting Posture on Swallowing Function in Healthy Adult Women: A Cross-Sectional Study
  Katsuya Nakamura, Shinsuke Nagami, Chiharu Kurozumi, Shu Harayama, Mayu Nakamura, Masahiro Ikeno, Jitsuro Yano, Tomonori Yokoyama, Shusaku Kanai, Shinya Fukunaga
  Dysphagia.2023; 38(1): 379.     CrossRef
• The effect of voice training interventions on patients with oropharyngeal dysphagia: a systematic review
  Chunyan Niu, Wenyan Zhou, Haifang Wang, Yingying Zhang, Jianzheng Cai, Nini Lu, Yalan Wang
  European Archives of Oto-Rhino-Laryngology.2023; 280(3): 973.     CrossRef
• Dysphagia Requiring Medical Attention in Parkinson’s Disease: A Korean Population-Based Study
  Seungwoo Cha, Won Kee Chang, Hee-Mun Cho, Kyungdo Han, Nam-Jong Paik, Sohyun Kwon, Won-Seok Kim
  Journal of Korean Medical Science.2023;[Epub]     CrossRef
• Long-Term Effectiveness of Physical Exercise-Based Swallowing Interventions for Older Adults with Dementia in a Day-Care Center
  Chia-Hui Chen, Chia-Yu Lin, Chiao-Ling Chen, Kuan-Ting Chen, Cho Lee, Ya-Hsin Yu, Chiao-Yu Shih
  Healthcare.2023; 11(9): 1262.     CrossRef
• Maximum phonation time: an independent predictor of late-onset pneumonia after esophageal cancer surgery
  Kakeru Tawada, Eiji Higaki, Tetsuya Abe, Jun Takatsu, Hironori Fujieda, Takuya Nagao, Koji Komori, Seiji Ito, Masahiro Yoshida, Isao Oze, Yasuhiro Shimizu
  Diseases of the Esophagus.2023;[Epub]     CrossRef
• Correlation Between Articulatory Diadochokinetic Parameters and Dysphagia Parameters in Subacute Stroke Patients
  Back Min Oh, Hyun Seok, Sang-Hyun Kim, Seung Yeol Lee, Su Jung Park, Beom Jin Kim, Hyun Jung Kim
  Annals of Rehabilitation Medicine.2023; 47(3): 192.     CrossRef
• Deterioration of Cough, Respiratory, and Vocal Cord Functions in Patients with Multiple System Atrophy
  Takashi Asakawa, Mieko Ogino, Naomi Tominaga, Naoto Ozaki, Jin Kubo, Wataru Kakuda
  Neurology International.2023; 15(4): 1227.     CrossRef
• Swallowing Outcomes Following Voice Therapy in Multiple System Atrophy with Dysphagia: Comparison of Treatment Efficacy with Parkinson’s Disease
  Alyssa Park, Su-Jeong Jang, No-Eul Kim, Tae-Hui Kim, Young Ho Sohn, HyangHee Kim, Sung-Rae Cho
  Dysphagia.2022; 37(1): 198.     CrossRef
• Using Voice Change as an Indicator of Dysphagia: A Systematic Review
  Karoline Weber dos Santos, Esther da Cunha Rodrigues, Rafaela Soares Rech, Eliana Márcia da Ros Wendland, Matheus Neves, Fernando Neves Hugo, Juliana Balbinot Hilgert
  Dysphagia.2022; 37(4): 736.     CrossRef
• Predicting Aspiration Using the Functions of Production and Quality of Voice in Dysphagic Patients
  Young-Jin Song, Hae-Na Lee, Young-Jin Yoo, Kyoung Hyo Choi, So-Hee Jung, Jeong-Hoon Lee
  Journal of the Korean Dysphagia Society.2022; 12(1): 50.     CrossRef
• Quantitative Measurement of Dysphonia Severity in Patients With Stroke With Unilateral Vocal Cord Palsy
  Min Kyu Choi, Eo Jin Park, Seung Don Yoo
  Brain & Neurorehabilitation.2022;[Epub]     CrossRef
• Voice Therapy in the Context of the COVID-19 Pandemic: Guidelines for Clinical Practice
  Adrián Castillo-Allendes, Francisco Contreras-Ruston, Lady Catherine Cantor-Cutiva, Juliana Codino, Marco Guzman, Celina Malebran, Carlos Manzano, Axel Pavez, Thays Vaiano, Fabiana Wilder, Mara Behlau
  Journal of Voice.2021; 35(5): 717.     CrossRef
• Terapia Vocal No Contexto Da Pandemia Do Covid-19; Orientações Para A Prática Clínica
  Adrián Castillo-Allendes, Francisco Contreras-Ruston, Lady Cantor, Juliana Codino, Marco Guzman, Celina Malebran, Carlos Manzano, Axel Pavez, Thays Vaiano, Fabiana Wilder, Mara Behlau
  Journal of Voice.2021; 35(5): 808.e13.     CrossRef
• Terapia de voz en el contexto de la pandemia covid-19; recomendaciones para la práctica clínica
  Adrián Castillo-Allendes, Francisco Contreras-Ruston, Lady Cantor, Juliana Codino, Marco Guzman, Celina Malebran, Carlos Manzano, Axel Pavez, Thays Vaiano, Fabiana Wilder, Mara Behlau
  Journal of Voice.2021; 35(5): 808.e1.     CrossRef
• Sensitivity and Specificity of Bedside Screening Tests for Detection of Aspiration in Patients Admitted to a Public Rehabilitation Hospital
  Leandro Castro Velasco, Rui Imamura, Ana Paula Valeriano Rêgo, Priscilla Rabelo Alves, Lorena Pacheco da Silva Peixoto, José de Oliveira Siqueira
  Dysphagia.2021; 36(5): 821.     CrossRef
• RETRACTED: Effect of the Mendelsohn maneuver and swallowing training in patients with senile vascular dementia complicated with dysphagia
  Jianrong Zhang, Yu’e Wu, Yanfang Huang, Shuqing Zhang, Liuqin Xu, Xiaoyun Huang, Xingshui Wang, Qingping Huang
  Journal of International Medical Research.2021;[Epub]     CrossRef
• Use of the Penetration-Aspiration Scale in Dysphagia Research: A Systematic Review
  James C. Borders, Danielle Brates
  Dysphagia.2020; 35(4): 583.     CrossRef
• Does the right or left hemisphere involvement affect swallowing in patients with hemiplegia?
  Cetin Sayaca, Taha Yasin Sapcíoglu, Defne Kaya
  NeuroRehabilitation.2020; 46(4): 501.     CrossRef
• Association between phonation and the vowel quadrilateral in patients with stroke
  Eo Jin Park, Jae Hoon Kim, Young Hwa Choi, Jung Eun Son, Seung Ah Lee, Seung Don Yoo
  Medicine.2020; 99(39): e22236.     CrossRef
• Dysphagia in Parkinson's Disease
  Sonoko Nozaki
  The Japanese Journal of Rehabilitation Medicine.2019; 56(3): 195.     CrossRef
• Oro-Pharyngeal Dysphagia in Parkinson’s Disease and Related Movement Disorders
  Miseon Kwon, Jae-Hong Lee
  Journal of Movement Disorders.2019; 12(3): 152.     CrossRef

Objective
To evaluate the usefulness of the quantitative assessment of pain perception (QAPP) in diabetic polyneuropathy (DPN) patients.
Methods
Thirty-two subjects with DPN were enrolled in this study. The subjects’ pain perception was assessed quantitatively. Current perception threshold (CPT) and pain equivalent current (PEC) were recorded. All patients were tested with a nerve conduction study (NCS) for evaluation of DPN and pain-related evoked potential (PREP) for evaluation of small fiber neuropathy (SFN) on bilateral upper and lower limbs. All patients were asked to participate in tests such as visual analogue scale (VAS) and SF-36 Health Survey Version 2 to evaluate their subjective pain and quality of life, respectively.
Results
The PEC of QAPP showed significant correlations with VAS (p=0.002) and physical function surveyed with SF-36 Health Survey Version 2 (p=0.035). The results of QAPP had no correlation with NCS, but there was a significant relationship between the CPT of QAPP and PREP (p=0.003).
Conclusion
The QAPP may be useful not only in providing objective evaluations of subjective pain in patients with DPN but also in the assessment of diabetic SFN.

Citations

• Structural Nerve Remodeling at 3-T MR Neurography Differs between Painful and Painless Diabetic Polyneuropathy in Type 1 or 2 Diabetes
  Johann M. E. Jende, Jan B. Groener, Zoltan Kender, Christian Rother, Artur Hahn, Tim Hilgenfeld, Alexander Juerchott, Fabian Preisner, Sabine Heiland, Stefan Kopf, Peter Nawroth, Martin Bendszus, Felix T. Kurz
  Radiology.2020; 294(2): 405.     CrossRef
• Effect of Topical Capsaicin on Painful Sensory Peripheral Neuropathy in Patients with Type 2 Diabetes: A Double-Blind Placebo-Controlled Randomised Clinical Trial
  Batakeh Ba Agoons, Mesmin Dehayem Yefou, Jean-Claude Katte, Martine Claude Etoa Etoga, Dayawa D Agoons, Faustin Yepnjio, Anne Boli, Yves Wasnyo, Eugene Sobngwi, Jean-Claude Mbanya
  Cureus.2020;[Epub]     CrossRef

Objective
To investigate appropriate treatment time and useful bone turnover markers (BTMs) for monitoring bone turnover during the postmenopausal period, we analyzed changes of two bone resorption markers; serum carboxyterminal telopeptide of collagen I (s-CTX), urine deoxypyridinoline (u-DPD), one bone formation marker; serum osteocalcin (s-OC), and bone mineral density (BMD) in Korean postmenopausal women.
Methods
Seventy-eight menopausal women were divided into three groups according to postmenopausal period: group I (0–5 years), group II (6–10 years), group III (≥10 years). All groups were subdivided into an osteoporosis group (T-score≤-2.5) and a non-osteoporosis group (T-score>-2.5). BTMs such as s-CTX, u-DPD, s-OC, and BMD (g/cm2) were measured by dual-energy X-ray absorptiometry (DXA) in all patients. Analysis of variables among groups based on the postmenopausal period was performed using ANOVA.
Results
There was significant negative correlation between BMD and postmenopausal period. The levels of all BTMs including s-CTX, u-DPD, and s-OC were highest in group II and the increased levels of all BTMs subsequently declined in group III. The levels of BTMs were higher in the osteoporosis groups than in the nonosteoporosis groups in all subjects. It was statistically significant that the level of s-CTX in group I was higher in the osteoporosis group than in the non-osteoporosis group.
Conclusion
This study showed that bone resorption and bone formation were the highest 5–10 years after menopause, and s-CTX is more useful than u-DPD among the bone resorption markers. It’s important to measure serially both BMD and BTM within 10 years after menopause for accurate diagnosis and management for postmenopausal osteoporosis.

Citations

• Alternating Aerobics with Resistance Exercise Improves Bone Density and Circulating Irisin Levels in Postmenopausal Women
  MINGXIAN CHEN, YUAN ZHANG, XINKAI YU, QUN ZUO
  Medicine & Science in Sports & Exercise.2025; 57(5): 921.     CrossRef
• Isovitexin, a natural adiponectin agonist, prevents glucocorticoid-induced osteosarcopenia
  Chirag Kulkarni, Saroj Kumar, Shamima Khatoon, Sreyanko Sadhukhan, Kaveri R. Washimkar, Akhilesh Kumar, Shivani Sharma, Swati Rajput, Konica Porwal, Madhav Nilakanth Mugale, Srikanta Kumar Rath, Madan Madhav Godbole, Sabyasachi Sanyal, Navin Kumar, Ambris
  Endocrine.2025;[Epub]     CrossRef
• Changes in bone mineral density and clinical parameters after stroke in elderly patients with osteopenia
  Yeong Kyun Bae, Myeong Hun Kang, Jae Hyun Lee, Young Joo Sim, Ho Joong Jeong, GhiChan Kim
  Medicine.2024; 103(4): e37028.     CrossRef
• Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases
  Monika Martiniakova, Roman Biro, Veronika Kovacova, Martina Babikova, Nina Zemanova, Vladimira Mondockova, Radoslav Omelka
  Journal of Molecular Medicine.2024; 102(4): 435.     CrossRef
• Quality of life as an indicator of connective tissue condition in women with metabolic syndrome without estrogen support
  E. S. Krutikov, Z. S. Rumyantseva, N. S. Tribrat, E. Yu. Zyablitskaya, V. B. Demyanova, G. A. Puchkina, N. V. Efremova, A. A. Gorbunov
  Сибирский научный медицинский журнал.2024; 44(1): 147.     CrossRef
• Molecular mechanisms of poor osseointegration in irradiated bone: In vivo study in a rat tibia model
  Omar Omar, Louise Rydén, Abdel Rahman Wamied, Ibrahim Al‐Otain, Hussain Alhawaj, Hatem Abuohashish, Faisal Al‐Qarni, Lena Emanuelsson, Anna Johansson, Anders Palmquist, Peter Thomsen
  Journal of Clinical Periodontology.2024; 51(9): 1236.     CrossRef
• Effects of daily probiotic supplementation with Lactobacillus acidophilus on calcium status, bone metabolism biomarkers, and bone mineral density in postmenopausal women: a controlled and randomized clinical study
  Iskandar Azmy Harahap, Małgorzata Moszak, Magdalena Czlapka-Matyasik, Katarzyna Skrypnik, Paweł Bogdański, Joanna Suliburska
  Frontiers in Nutrition.2024;[Epub]     CrossRef
• Pregnancy and lactation associated osteoporotic vertebral fracture: the neurosurgical perspective through a multicentric study
  Teresa Somma, Ciro Mastantuoni, Rossella Rispoli, Ilaria Bove, Andrea Bocchino, Antonio Stefano Salcuni, Lorenza Driul, Felice Esposito, Paolo Cappabianca, Enrico Tessitore, Barbara Cappelletto
  Neurosurgical Review.2024;[Epub]     CrossRef
• Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease
  Amin Ullah, Yongxiu Chen, Rajeev K. Singla, Dan Cao, Bairong Shen
  Ageing Research Reviews.2024; 101: 102505.     CrossRef
• Effects of isoflavone interventions on bone turnover markers and factors regulating bone metabolism in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials
  Ratchanon Inpan, Nahathai Dukaew, Mingkwan Na Takuathung, Supanimit Teekachunhatean, Nut Koonrungsesomboon
  Archives of Osteoporosis.2024;[Epub]     CrossRef
• Potential Effect of Nigella sativa on Osteoporosis in Ovariectomized Rats: Possible Role of Hypoxia Inducible Factor 1-α
  Noha S. Sobhy, Ansam Aly Seif, Doaa A. Abou-Bakr, Safaa M. Shaker, Dalia A. Saad
  Journal of Evolutionary Biochemistry and Physiology.2023; 59(2): 395.     CrossRef
• Impact of vitamin D supplementation on markers of bone turnover: Systematic review and meta‐analysis of randomised controlled trials
  Mohammad Hassan Sohouli, Sicong Wang, Faisal Almuqayyid, Mariana Papini Gabiatti, Fateme Mozaffari, Zahra Mohamadian, Nazanin Koushki, Kamar Allayl Alras, Abdullah M. AlHossan, Saud K. Albatati, Aya Alfardous Alazm, Saeed Baradwan, Mihnea‐Alexandru Găman,
  European Journal of Clinical Investigation.2023;[Epub]     CrossRef
• The combined effect of rowing exercise and the intake of functional foods containing inulin on muscle mass and bone mineral density in older Japanese women
  Hiroko Murata, Qiwei Zhang, Tomoko Ito, Ryoko Kawakami, Shizuo Sakamoto, Suguru Torii, Shigenobu Shibata, Kumpei Tanisawa, Mitsuru Higuchi
  Geriatrics & Gerontology International.2023; 23(11): 779.     CrossRef
• A Risk Assessment Tool for Identifying Osteoporosis in Older Women with Type 2 Diabetes Mellitus
  Fenghui Pan, Wenxia Cui, Lei Gao, Xiaoting Shi, Mingrui Zhang, Man Li, Haiyan Yang, Yun Hu
  Experimental and Clinical Endocrinology & Diabetes.2022; 130(07): 426.     CrossRef
• Association of bone-related biomarkers with femoral neck bone strength
  Ning Xia, Yun Cai, Wei Wang, Chen Bao, Yunming Li, Qingyun Xie, Wei Xu, Da Liu
  BMC Musculoskeletal Disorders.2022;[Epub]     CrossRef
• Clinical study evaluating β-blockers use and fracture risk in patients with primary osteoporosis Running title
  Mona Abd Elrafea Abdo, Osama Mohamed Ibrahim, Sahar Mohamed El-Haggar, Salwa Elmorsy El-Sayed
  International journal of health sciences.2022; : 1383.     CrossRef
• Polydatin administration attenuates the severe sublesional bone loss in mice with chronic spinal cord injury
  Jiheng Zhan, Dan Luo, Bingde Zhao, Shudong Chen, Jiyao Luan, Junhua Luo, Yu Hou, Yonghui Hou, Wenke Xu, Wanying Yan, Ji Qi, Xing Li, Qing Zhang, Dingkun Lin
  Aging.2022; 14(21): 8856.     CrossRef
• Oligopin® Supplementation Mitigates Oxidative Stress in Postmenopausal Women with Osteopenia: A Randomized, Double-blind, Placebo-Controlled Trial
  Ziba Majidi, Mohammad Ansari, Zhila Maghbooli, Afsaneh Ghasemi, Shadi Sadat Seyyed Ebrahimi, Arash Hossein-nezhad, Solaleh Emamgholipour
  Phytomedicine.2021; 81: 153417.     CrossRef
• Association between Serum Osteocalcin Levels and Metabolic Syndrome according to the Menopausal Status of Korean Women
  Jin-Sook Moon, Mi Hyeon Jin, Hyun-Min Koh
  Journal of Korean Medical Science.2021;[Epub]     CrossRef
• Muskuloskelettale Labordiagnostik im Leistungssport
  Maximilian M. Delsmann, Julian Stürznickel, Michael Amling, Peter Ueblacker, Tim Rolvien
  Der Orthopäde.2021; 50(9): 700.     CrossRef
• Sex-related differences in bone metabolism in osteoporosis observational study
  Kyu Hwan Choi, Jong Ho Lee, Dong Gyu Lee
  Medicine.2021; 100(21): e26153.     CrossRef
• The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis
  Kevin D. Seely, Cody A. Kotelko, Hannah Douglas, Brandon Bealer, Amanda E. Brooks
  International Journal of Molecular Sciences.2021; 22(17): 9452.     CrossRef
• A Multi-Institutional Randomized Controlled Trial to Investigate Whether Zoledronate Prevents Bone Loss After Discontinuation of Denosumab: The Study Protocol of Denosumab Sequential Therapy (DST) Trial
  Chia-Che Lee, Chen-Yu Wang, Chih-Chien Hung, Chuan-Ching Huang, Chung-Yi Li, Hsuan-Yu Chen, Yun-Liang Chang, Wo-Jan Tseng, Ting-Ming Wang, Rong-Sen Yang, Tze-Hong Wong, Shau-Huai Fu
  Frontiers in Medicine.2021;[Epub]     CrossRef
• Bone mineral density of proximal femur in adult Chinese females
  Fanjie Li, Yibin Du
  Journal of Orthopaedics.2020; 22: 53.     CrossRef
• Variation of urinary and serum bone turnover marker reference values among pre and postmenopausal women in Asia: a systematic review
  Hasanga Rathnayake, Sarath Lekamwasam, Chandima Wickramatilake, Janaka Lenora
  Archives of Osteoporosis.2020;[Epub]     CrossRef

• Soluble Biomarkers of Osteoporosis and Osteoarthritis, from Pathway Mapping to Clinical Trials: An Update

  
  Előd Nagy, Csilla Nagy-Finna, Horațiu-Valeriu Popoviciu, Béla Kovács
  Clinical Interventions in Aging.2020; Volume 15: 501.     CrossRef
• Metabolomics profiling reveals Echinops latifolius Tausch improves the trabecular micro-architecture of ovariectomized rats mainly via intervening amino acids and glycerophospholipids metabolism
  Jiaqi Wang, Xin Dong, Feixiang Ma, Chunyan Li, Ren Bu, Jingkun Lu, Jianping Gao, Peifeng Xue
  Journal of Ethnopharmacology.2020; 260: 113018.     CrossRef
• Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis
  Jianquan He, Shuangbin Xu, Bangzhou Zhang, Chuanxing Xiao, Zhangran Chen, Fuyou Si, Jifan Fu, Xiaomei Lin, Guohua Zheng, Guangchuang Yu, Jian Chen
  Aging.2020; 12(9): 8583.     CrossRef
• Folate and Vitamin B‐12 Status Is Associated With Bone Mineral Density and Hip Strength of Postmenopausal Chinese‐Singaporean Women
  Maria Kalimeri, Francesca Leek, Nan Xin Wang, Huann Rong Koh, Nicole C Roy, David Cameron‐Smith, Marlena C Kruger, Christiani Jeyakumar Henry, John J Totman
  JBMR Plus.2020;[Epub]     CrossRef
• The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review
  Sofia Marini, Giuseppe Barone, Alice Masini, Laura Dallolio, Laura Bragonzoni, Yari Longobucco, Francesca Maffei
  Frontiers in Endocrinology.2020;[Epub]     CrossRef
• Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications
  Elizaveta A. Shatunova, Maksim A. Korolev, Vitaly O. Omelchenko, Yuliya D. Kurochkina, Anna S. Davydova, Alya G. Venyaminova, Mariya A. Vorobyeva
  Biomedicines.2020; 8(11): 527.     CrossRef
• Bone turnover markers in osteoporosis - a common position on their use by the Society for Metabolic Skeletal Diseases (SMOS) of the Czech Medical Association JEP and the Czech Society of Clinical Biochemistry (CSCB)
  R Pikner, V Palička, J Rosa, V Zikán, Z Švagera, J Racek, B Friedecký, J Kratochvíla, T Zima
  Klinická biochemie a metabolismus.2020; 28(2): 48.     CrossRef
• A meta-analysis of serum osteocalcin level in postmenopausal osteoporotic women compared to controls
  Zhongyu Liu, Ruiqiang Chen, Yutong Jiang, Yang Yang, Lei He, Chunxiao Luo, Jianwen Dong, Limin Rong
  BMC Musculoskeletal Disorders.2019;[Epub]     CrossRef

Objective
To assess the clinical outcome of chemical synovectomy with rifampicin in hemophilic arthropathy by using the World Federation of Hemophilia (WFH) scoring system and plain radiograph.
Methods
We performed rifampicin synovectomy (RS) on 30 joints of 28 hemophilic patients diagnosed as hemophilic arthropathy stage I–III (based on Fernandez-Palazzi clinical classification). Clinical status (bleeding frequency, pain, joint physical status) and radiological staging were evaluated as parts of the WFH scoring system before and 1 year after RS. The patients were divided into two groups by the Arnold-Hilgartner scale of the initial X-ray as stage 3 or less for the low-stage group (n=17) and over 3 for the high-stage group (n=13).
Results
Total WFH joint physical scores were reduced after injection, and the number of bleeding episodes and pain showed especially significant improvement. For other subscores of the WFH joint physical score, only swelling, range of motion, and crepitus showed statistically significant improvement. According to the severity of the radiologic finding, the WFH joint physical score of both the low-stage and high-stage groups showed significant improvement. In the radiological aspect, the low-stage group, without joint space narrowing at the initial plain radiograph, showed no further aggravation after injection. However, in the high-stage group, radiology found aggravation regardless of the procedure.
Conclusion
It is suggested that chemical synovectomy with rifampicin may prevent hemarthrosis and improve clinical symptoms. Especially in the early stage of arthropathy without joint-space narrowing, it seems to have an additional benefit that delays radiological aggravation and preserves joint status.

Citations

• Global trends in hemophilic arthropathy research: a bibliometric and visualization analysis
  Zhihao Wei, Lijun Ou, Sheng Chai, Dongdong Zhang, Gangjian Tang
  Frontiers in Medicine.2025;[Epub]     CrossRef
• Rifampicin-Induced Toxic Hepatitis in a Patient with Hemophilia After Chemical Synovectomy
  Mehmet Can Uğur, Semih Aydoğdu, Elçil Kaya Biçer, Can Balkan, Kaan Kavaklı
  Turkish Journal of Hematology.2024; : 64.     CrossRef
• Ultrasound-guided joint procedures in hemophilia: technique, indications and tips
  Hortensia De la Corte-Rodriguez, E. Carlos Rodriguez-Merchan, M. Teresa Alvarez-Roman, Primitivo Gomez-Cardero, Victor Jimenez-Yuste
  Expert Review of Hematology.2024; 17(8): 419.     CrossRef
• Synovitis in hemophilia: preventing, detecting, and treating joint bleeds
  E. Carlos Rodriguez-Merchan
  Expert Review of Hematology.2023; 16(7): 525.     CrossRef
• Hemophilic arthropathy: how to diagnose subclinical bleeding early and how to orthopedically treat a damaged joint
  E. Carlos Rodriguez-Merchan
  Expert Review of Hematology.2023; 16(9): 651.     CrossRef
• The role of intraarticular injections of hyaluronic acid in joint pain relief in hemophilic arthropathy
  E. Carlos Rodriguez-Merchan
  Expert Review of Hematology.2023; 16(11): 811.     CrossRef
• Successful Chemical Synovectomy in a Patient with Acquired von Willebrand Syndrome with Chronic Synovitis Due to Recurrent Knee Hemarthrosis: A Case Report
  Roberta Gualtierotti, Claudio De Magistris, Eugenia Biguzzi, Jacopo Acquati Lozej, Alessandra Iurlo, Luigi Piero Solimeno, Flora Peyvandi
  Rheumatology and Therapy.2022; 9(5): 1465.     CrossRef
• Radiosynovectomy for the Treatment of Chronic Hemophilic Synovitis: An Old Technique, but Still Very Effective
  Emerito Carlos Rodriguez-Merchan, Hortensia De la Corte-Rodriguez, Maria Teresa Alvarez-Roman, Primitivo Gomez-Cardero, Victor Jimenez-Yuste
  Journal of Clinical Medicine.2022; 11(24): 7475.     CrossRef
• Synovitis and synovectomy in haemophilia
  Lize F. D. van Vulpen, Sylvia Thomas, Swapnil A. Keny, Shubhranshu S. Mohanty
  Haemophilia.2021; 27(S3): 96.     CrossRef
• Low‐dose surgical prophylaxis: Optimization of use of World Federation of Hemophilia Humanitarian Aid donated clotting factor concentrates to developing countries
  Magdy El Ekiaby, Assad Haffar
  Haemophilia.2020; 26(S3): 11.     CrossRef

Objective
To analyze the respiratory function of high cervical cord injury according to ventilator dependence and to examine the correlations between diaphragm movement found on fluoroscopy and sensory and motor functions.
Methods
A total of 67 patients with high cervical spinal cord injury (SCI), admitted to our hospital were enrolled in the study. One rehabilitation physician performed sensory and motor examinations on all patients while each patient was in the supine position on the American Spinal Injury Association (ASIA) standard. In addition, fluoroscopic diaphragm movement studies and bedside spirometry were performed.
Results
Bedside spirometry and diaphragm fluoroscopic tests were analyzed according to ventilator dependence. Forced vital capacity and maximal inspiratory pressure were significantly higher in the ventilator weaned group. Natural breathing during the fluoroscopic diaphragm examinations and ventilator weaning showed statistical significance with the movement on the right, while deep breathing showed statistical significance with the movement on both sides. Deep breathing movement has correlation with the C5 key muscle. Diaphragm movement has correlation with right C3 and bilateral C4 sensory functions.
Conclusion
The present expansion study showed that, through simple bedside physical examinations, rehabilitation physicians could relatively easily predict diaphragm movement and respiratory function recovery, which showed significance with ventilator weaning in patients with high cervical SCI.

Citations

• Predicting extubation in patients with traumatic cervical spinal cord injury using the diaphragm electrical activity during a single maximal maneuver
  Rui Zhang, Xiaoting Xu, Hui Chen, Jennifer Beck, Christer Sinderby, Haibo Qiu, Yi Yang, Ling Liu
  Annals of Intensive Care.2023;[Epub]     CrossRef
• Respiratory Complications and Weaning Considerations for Patients with Spinal Cord Injuries: A Narrative Review
  Kristopher A. Hendershot, Kristine H. O’Phelan
  Journal of Personalized Medicine.2022; 13(1): 97.     CrossRef
• Separation from mechanical ventilation and survival after spinal cord injury: a systematic review and meta-analysis
  Annia F. Schreiber, Jacopo Garlasco, Fernando Vieira, Yie Hui Lau, Dekel Stavi, David Lightfoot, Andrea Rigamonti, Karen Burns, Jan O. Friedrich, Jeffrey M. Singh, Laurent J. Brochard
  Annals of Intensive Care.2021;[Epub]     CrossRef

Objective
To investigate medical comorbidities and needs for medical and rehabilitation services of adults with cerebral palsy (CP) in Korea.
Methods
This was a prospective cross-sectional study. One hundred fifty-four adults with CP were enrolled in the study between February 2014 and December 2014. Information was obtained from participants regarding functional status, demographic and socioeconomic data, medical problems, and requirements for and utilization of medical and rehabilitation services.
Results
The participants included 93 males and 61 females with a mean age of 40.18±9.15 years. The medical check-up rate of adults with CP was lower than that of healthy adults and the total population with disabilities (53.2% vs. 58.6% vs. 70.4%). A quarter of the subjects failed to visit the hospital during the past year, and the main reason was the financial burden. Due to a cost burden and lack of knowledge, more than one-third of the subjects had unmet needs for rehabilitation services; the majority reported needs for rehabilitation services, such as physical therapy for pain management.
Conclusion
The medical check-up rate was lower in the adults with CP, even though their medical comorbidities were not less than those of healthy people. Several non-medical reasons hindered them from receiving proper medical and rehabilitation services. Such barriers should be managed effectively.

Citations

• Exploring the Characteristics and Utilization of General Practice Healthcare by Adults With Cerebral Palsy: A Systematic Review
  Prue Morgan, Asfarina Zanudin
  Journal of Primary Care & Community Health.2025;[Epub]     CrossRef
• Access, use and satisfaction with physiotherapy services among adults with cerebral palsy living in the United Kingdom and Ireland
  Manjula Manikandan, Elizabeth Cassidy, Gemma Cook, Cherry Kilbride, Claire Kerr, Aisling Walsh, Michael Walsh, Jennifer M. Ryan
  Disability and Rehabilitation.2023; 45(13): 2160.     CrossRef
• Prevalence and incidence of chronic conditions among adults with cerebral palsy: A systematic review and meta‐analysis
  Jennifer M. Ryan, Fatemah Albairami, Thomas Hamilton, Nigel Cope, Noor Amirah Amirmudin, Manjula Manikandan, Cherry Kilbride, Valerie L. Stevenson, Emma Livingstone, Jennifer Fortune
  Developmental Medicine & Child Neurology.2023; 65(9): 1174.     CrossRef
• Impairments and comorbidities in adults with cerebral palsy and spina bifida: a meta-analysis
  Jane N. T. Sattoe, Sander R. Hilberink
  Frontiers in Neurology.2023;[Epub]     CrossRef
• Situation analysis of rehabilitation services for persons with disabilities in Bangladesh: identifying service gaps and scopes for improvement
  Mahmudul Hassan Al Imam, Israt Jahan, Manik Chandra Das, Mohammad Muhit, Delwar Akbar, Nadia Badawi, Gulam Khandaker
  Disability and Rehabilitation.2022; 44(19): 5571.     CrossRef
• Health service use among adults with cerebral palsy: a mixed‐methods systematic review
  Manjula Manikandan, Claire Kerr, Grace Lavelle, Michael Walsh, Aisling Walsh, Jennifer M Ryan
  Developmental Medicine & Child Neurology.2022; 64(4): 429.     CrossRef
• Use of health services and unmet needs among adults with cerebral palsy in Ireland
  Manjula Manikandan, Claire Casey, Anne Doyle, Claire Kerr, Michael Walsh, Aisling Walsh, Jennifer M Ryan
  Developmental Medicine & Child Neurology.2022; 64(10): 1270.     CrossRef
• Satisfying medical and rehabilitation needs positively influences returning to work after a work-related injury: an analysis of national panel data from 2018 to 2019
  Suk Won Bae, Min-Yong Lee, Shin Who Park, Gangpyo Lee, Ja-Ho Leigh
  BMC Public Health.2021;[Epub]     CrossRef
• Epidemiology of Cerebral Palsy in Adulthood: A Systematic Review and Meta-analysis of the Most Frequently Studied Outcomes
  Marloes van Gorp, Sander R. Hilberink, Suzie Noten, Joyce L. Benner, Henk J. Stam, Wilma M.A. van der Slot, Marij E. Roebroeck
  Archives of Physical Medicine and Rehabilitation.2020; 101(6): 1041.     CrossRef
• Emerging Issues in Cerebral Palsy Associated With Aging: A Physiatrist Perspective
  You Gyoung Yi, Se Hee Jung, Moon Suk Bang
  Annals of Rehabilitation Medicine.2019; 43(3): 241.     CrossRef

Objective
To identify the center of extensor indicis (EI) muscle through cadaver dissection and compare the accuracy of different techniques for needle electromyography (EMG) electrode insertion.
Methods
Eighteen upper limbs of 10 adult cadavers were dissected. The center of trigonal EI muscle was defined as the point where the three medians of the triangle intersect. Three different needle electrode insertion techniques were introduced: M1, 2.5 cm above the lower border of ulnar styloid process (USP), lateral aspect of the ulna; M2, 2 finger breadths (FB) proximal to USP, lateral aspect of the ulna; and M3, distal fourth of the forearm, lateral aspect of the ulna. The distance from USP to the center (X) parallel to the line between radial head to USP, and from medial border of ulna to the center (Y) were measured. The distances between 3 different points (M1– M3) and the center were measured (marked as D1, D2, and D3, respectively).
Results
The median value of X was 48.3 mm and that of Y was 7.2 mm. The median values of D1, D2 and D3 were 23.3 mm, 13.3 mm and 9.0 mm, respectively.
Conclusion
The center of EI muscle is located approximately 4.8 cm proximal to USP level and 7.2 mm lateral to the medial border of the ulna. Among the three methods, the technique placing the needle electrode at distal fourth of the forearm and lateral to the radial side of the ulna bone (M3) is the most accurate and closest to the center of the EI muscle.

Citations

• Ultrasonographic Analysis of Optimal Needle Placement for Extensor Indicis
  Jin Young Kim, Hyun Seok, Sang-Hyun Kim, Yoon-Hee Choi, Jun Young Ahn, Seung Yeol Lee
  Annals of Rehabilitation Medicine.2020; 44(6): 450.     CrossRef

Objective
To analyze patient characteristics of cancer rehabilitation and outcomes at our hospital.
Methods
This retrospective study analyzed 580 patients, who underwent cancer rehabilitation at our hospital and rehabilitation outcome after therapy were investigated. The relationship between the initial Barthel index and discharge outcomes was investigated, with a special focus on cancer patients with bone metastasis. The Barthel index and performance status (Eastern Cooperative Oncology Group) before and after rehabilitation were analyzed, and threshold value of home discharge was calculated from a receiver operating characteristic curve (ROC). General criteria for home discharge from our hospital included independence in performing basic activities of daily living such as bathing, feeding, and toileting or availability of home support from a family member/caregiver.
Results
The outcomes after rehabilitation among all the patients were as follows: discharge home 59%, death 13%, and others 27%. Statistical differences were observed between the initial and final values of the Barthel index in patients with bone metastasis, who could be discharged home (p=0.012). ROC analysis of the initial Barthel index for predicting home discharge revealed a threshold value of 60, sensitivity of 0.76, and specificity of 0.72.
Conclusion
The patients with bone metastasis had a lower rate of home discharge and a higher rate of mortality than all the study patients who underwent cancer rehabilitation at our hospital. It is proposed that at the time of initiation of rehabilitation for patients with bone metastasis, an initial Barthel index lower than 60 might predict a worse outcome than home discharge.

Citations

• Factors Associated with Discharge Destination in Patients with Bone Metastases
  Hanako Himematsu, Yukiyo Shimizu, Tami Yuhara, Kenta Hiasa, Masashi Yamazaki, Yasushi Hada
  Medicina.2024; 60(6): 881.     CrossRef
• Immediate family support is important to discharge home for cancer patient with bone metastasis after rehabilitation
  Ryosuke Ikeguchi, Manabu Nankaku, Rie Yamawaki, Hiroki Tanaka, Ryota Hamada, Takumi Kawano, Masanobu Murao, Gakuto Kitamura, Tatsuya Sato, Toru Nishikawa, Takashi Noguchi, Shinichi Kuriyama, Akio Sakamoto, Shuichi Matsuda
  Medicine.2021; 100(37): e27273.     CrossRef

Ulnar neuropathy at the wrist is an uncommon disease and pure ulnar sensory neuropathy at the wrist is even rarer. It is difficult to diagnose pure ulnar sensory neuropathy at the wrist by conventional methods. We report a
case
of pure ulnar sensory neuropathy at the hypothenar area. The lesion was localized between 3 cm and 5 cm distal to pisiform using orthodromic inching test of ulnar sensory nerve to stimulate at three points around the hypothenar area. Ultrasonographic examination confirmed compression of superficial sensory branch of the ulnar nerve. Further, surgical exploration reconfirmed compression of the ulnar nerve. This case report demonstrates the utility of orthodromic ulnar sensory inching test.

Citations

• Neurological improvement following revision of vascular graft remnants in the upper extremity
  Marie Bigot, Sima Vazquez, Sateesh Babu, Suguru Ohira, Ramin Malekan, Igor Laskowski, Jared Pisapia
  Journal of Vascular Surgery Cases, Innovations and Techniques.2024; 10(4): 101539.     CrossRef
• Localization of Ulnar Neuropathy at the Wrist Using Motor and Sensory Ulnar Nerve Segmental Studies
  Ki Hoon Kim, Beom Suk Kim, Min Jae Kim, Dong Hwee Kim
  Journal of Clinical Neurology.2022; 18(1): 59.     CrossRef

Compressive femoral neuropathy is a disabling condition accompanied by difficulty in hip flexion and knee extension. It may result from retroperitoneal hematoma or bleeding, or from complications associated with pelvic, hip surgery, and renal transplants. A 55-year-old female with autosomal dominant polycystic kidney disease presented with proximal muscle weakness in lower extremities. The patient experienced recurrent renal cyst infection, with aggravated weakness during each event. Electromyography and nerve conduction study revealed bilateral femoral neuropathy. Computed tomography and magnetic resonance images were added to further identify the cause. As a result, a diagnosis of femoral neuropathy caused by enlarged polycystic kidney was made. Cyst infection was managed with antibiotics. Renal function was maintained by frequent regular hemodialysis. While avoiding activities that may increase abdominal pressure, rehabilitation exercises were provided. Motor strength in hip flexion and knee extension improved, and was confirmed via electrodiagnostic studies.