Systemic lupus erythematosus(SLE) is a chronic inflammatory disease of unknown cause that may affect skin, joint, kidney, lung, heart, hematopoietic system and nervous system. The clinical features are very diverse but fatigue, fever, weight loss, rash, arthralgia, lymphadenopathy, and pleurisy are seen frequently. The neuropathies associated with SLE are mononeuropathy, progressive asymmetric motorsensory polyneuropathy, and radiculopathy, which occurred in 6 to 21%. The polyneuropathy is common in older age with long duration of diseae and shows segmental fibrinoid necrosis with transmural inflammatory cell infiltration of microvessels. But in rare cases, it occurs very early in the course of disease, which can not be explained by vasculitis only. We present a case of polyneuropathy in the early stage of SLE. The possible mechanism is cross reaction of the autoantibody mediated injury to peripheral nerve or direct antibody to peripheral nerve.