Central Nervous System Involvement in Eosinophilia-Myalgia Syndrome Associated with L-tryptophan Ingestion: A case report. |
Lee, Chang Hyung , Lee, Sang Heon , Kim, Se Joo |
Department of Rehabilitation Medicine, Korea University College of Medicine. |
Tryptophan복용후 중추신경계 침범을 동반한 호산구성 근육통 증후군 증례 보고 |
이창형, 이상헌, 김세주 |
고려대학교 의과대학 재활의학교실 |
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Abstract |
We report a case of Eosinophilia- Myalgia syndrome with central nervous system (CNS) involvement following ingestion of the essential amino acid, tryptophan. The Eosinophilia- Myalgia syndrome can be diagnosed when there is a severe myalgia and peripheral eosinophilia in the absence of other diseases causing eosinophilia. This condition has been associated with the ingestion of the tryptophan in many cases, but the amount and duration of ingestion have been yet to be elucidated. Although many cases have been reported, few cases involved the CNS. We present a 28 year- old male who complained of a severe myalgia and disorientation after taking the taken tryptophan for 2 weeks. Thorough examination revealed the peripheral eosinophilia, vasculitis on brain MRI, abnormal VEP, and muscle atrophy on muscle biopsy. Symptoms improved with the steroid pulse after discontinuation of the tryptophan. |
Key Words:
Eosinophilia-Myalgia syndrome, Central nervous system involvement, Tryptophan |
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